Patents by Inventor Peter J. Littrup
Peter J. Littrup has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11350905Abstract: The present invention provides improved methods and systems for generating enhanced images of a volume of tissue.Type: GrantFiled: June 18, 2019Date of Patent: June 7, 2022Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter J. Littrup, Gursharan Singh Sandhu, Mark Krycia, Mark Sak
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Patent number: 11197707Abstract: A method of cooling a material including the steps of (i) providing a cryotherapy instrument, (ii) positioning a portion of the cryotherapy instrument adjacent the material to be cooled, and (iii) circulating a cryogenic fluid through the cryotherapy instrument under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with cooling of the cryotherapy instrument is avoided.Type: GrantFiled: December 20, 2018Date of Patent: December 14, 2021Assignee: ADAGIO MEDICAL, INC.Inventors: Peter J. Littrup, Alexei V. Babkin, Robert V. Duncan, Pramod Kerkar, Sergey T. Boldarev
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Publication number: 20200022672Abstract: The present invention provides improved methods and systems for generating enhanced images of a volume of tissue.Type: ApplicationFiled: June 18, 2019Publication date: January 23, 2020Inventors: Nebojsa DURIC, Peter J. LITTRUP, Gursharan Singh SANDHU, Mark KRYCIA, Mark SAK
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Patent number: 10368831Abstract: The present invention provides improved methods and systems for generating enhanced images of a volume of tissue.Type: GrantFiled: December 1, 2017Date of Patent: August 6, 2019Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter J. Littrup, Gursharan Singh Sandhu, Mark Krycia, Mark Sak
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Publication number: 20190117288Abstract: A method of cooling a material including the steps of (i) providing a cryotherapy instrument, (ii) positioning a portion of the cryotherapy instrument adjacent the material to be cooled, and (iii) circulating a cryogenic fluid through the cryotherapy instrument under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with cooling of the cryotherapy instrument is avoided.Type: ApplicationFiled: December 20, 2018Publication date: April 25, 2019Applicant: ADAGIO MEDICAL, INC.Inventors: PETER J. LITTRUP, ALEXEI V. BABKIN, ROBERT V. DUNCAN, PRAMOD KERKAR, SERGEY T. BOLDAREV
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Patent number: 10159522Abstract: A device for freezing body tissue, the device having a main driving system capable of generating nitrogen under physical conditions near a critical point of a liquid-vapor system for the nitrogen. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas and the physical conditions include a pressure of about 33.5 atm.Type: GrantFiled: April 18, 2016Date of Patent: December 25, 2018Assignee: ADAGIO MEDICAL, INC.Inventors: Peter J. Littrup, Alexei V. Babkin, Robert V. Duncan, Pramod Kerkar, Sergey T. Boldarev
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Publication number: 20180153502Abstract: The present invention provides improved methods and systems for generating enhanced images of a volume of tissue.Type: ApplicationFiled: December 1, 2017Publication date: June 7, 2018Inventors: Nebojsa Duric, Peter J. Littrup, Gursharan Singh Sandhu, Mark Krycia, Mark Sak
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Publication number: 20160228173Abstract: A device for freezing body tissue, the device having a main driving system capable of generating nitrogen under physical conditions near a critical point of a liquid-vapor system for the nitrogen. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas and the physical conditions include a pressure of about 33.5 atm.Type: ApplicationFiled: April 18, 2016Publication date: August 11, 2016Applicant: ADAGIO MEDICAL, INC.Inventors: Peter J. LITTRUP, Alexie V. BABKIN, Robert V. DUNCAN, Pramod KERKAR, Sergey T. BOLDAREV
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Patent number: 9408656Abstract: A method of cooling a material including the steps of (i) providing a cryotherapy instrument, (ii) positioning a portion of the cryotherapy instrument adjacent the material to be cooled, and (iii) circulating a cryogenic fluid through the cryotherapy instrument under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with cooling of the cryotherapy instrument is avoided.Type: GrantFiled: November 22, 2013Date of Patent: August 9, 2016Assignee: ADAGIO MEDICAL, INC.Inventors: Peter J. Littrup, Alexei V. Babkin, Robert V. Duncan, Pramod Kerkar, Sergey T. Boldarev
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Patent number: 9345527Abstract: A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.Type: GrantFiled: November 9, 2011Date of Patent: May 24, 2016Assignee: CRYOMEDIX, LLCInventors: Alexei V. Babkin, Peter J. Littrup, William J. Nydam
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Patent number: 8870771Abstract: A method for categorizing whole-breast density is disclosed. The method includes the steps of exposing breast tissue to an acoustic signal; measuring a distribution of an acoustic parameter by analyzing the acoustic signal; and obtaining a measure of whole-breast density from said measuring step. An apparatus is also disclosed.Type: GrantFiled: May 5, 2008Date of Patent: October 28, 2014Assignee: Barbara Ann Karmanos Cancer InstituteInventors: Carri K. Glide-Hurst, Nebojsa Duric, Peter J. Littrup
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Patent number: 8814850Abstract: A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.Type: GrantFiled: April 17, 2009Date of Patent: August 26, 2014Assignee: Cryomedix, LLCInventors: Alexei V. Babkin, Peter J. Littrup, William J. Nydam
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Publication number: 20140221991Abstract: A method of cooling a material including the steps of (i) providing a cryotherapy instrument, (ii) positioning a portion of the cryotherapy instrument adjacent the material to be cooled, and (iii) circulating a cryogenic fluid through the cryotherapy instrument under physical conditions near a critical point of a liquid-vapor system for the cryogenic fluid. The critical point defines a point in a phase diagram of the liquid-vapor system where molar volumes are substantially equivalent for liquid and gas, whereby vapor lock associated with cooling of the cryotherapy instrument is avoided.Type: ApplicationFiled: November 22, 2013Publication date: August 7, 2014Applicant: CRYODYNAMICS, LLCInventors: PETER J. LITTRUP, ALEXEI V. BABKIN, ROBERT V. DUNCAN, PRAMOD KERKAR, SERGEY T. BOLDAREV
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Patent number: 8740891Abstract: A flexible multi-tubular cryoprobe, including a housing for receiving an inlet flow of near critical cryogenic fluid from a fluid source and for discharging an outlet flow of the cryogenic fluid. A plurality of fluid transfer tubes are securely attached to the housing. This includes a set of inlet fluid transfer tubes for receiving the inlet flow from the housing; and, a set of outlet fluid transfer tubes for discharging the outlet flow to the housing. Each of the fluid transfer tubes is formed of material that maintains flexibility in a full range of temperatures from ?200° C. to ambient temperature. Each fluid transfer tube has an inside diameter in a range of between about 0.10 mm and 1.0 mm and a wall thickness in a range of between about 0.01 mm and 0.30 mm. An end cap is positioned at the ends of the plurality of fluid transfer tubes to provide fluid transfer from the inlet fluid transfer tubes to the outlet fluid transfer tubes.Type: GrantFiled: November 19, 2008Date of Patent: June 3, 2014Assignee: Endocare, Inc.Inventors: Alexei V. Babkin, Peter J. Littrup, Robert V. Duncan, William J. Nydam
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Patent number: 8591503Abstract: A gas-based cryotherapy probe is provided with a shaft having a closed distal end adapted for insertion into a body. A supply conduit is disposed longitudinally within the shaft for flowing gas towards the distal end, and a return conduit is disposed longitudinally within the shaft for flowing gas from the distal end. The gas is maintained at a lower pressure within the return conduit than in the supply conduit. A heat exchanger is disposed within the shaft in thermal communication with the supply conduit and return conduit to exchange heat from gas in the supply conduit to gas in the return conduit. A vacuum jacket is adapted to provide thermal isolation of the heat exchanger from the shaft.Type: GrantFiled: January 23, 2008Date of Patent: November 26, 2013Assignee: Cryodynamics, LLCInventors: Peter J. Littrup, Alexei V. Babkin, Robert V. Duncan, Pramod Kerkar, Sergey T. Boldarev
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Patent number: 8387402Abstract: Methods and systems are provided for cooling an object with a cryogen having a critical point defined by a critical-point pressure and a critical-point temperature. A pressure of the cryogen is raised above a pressure value determined to provide the cryogen at a reduced molar volume that prevents vapor lock. Thereafter, the cryogen is placed in thermal communication with the object to increase a temperature of the cryogen along a thermodynamic path that maintains the pressure greater than the critical-point pressure for a duration that the cryogen and object are in thermal communication.Type: GrantFiled: March 11, 2011Date of Patent: March 5, 2013Assignee: Cryodynamics, LLCInventors: Peter J. Littrup, Alexei V. Babkin, Robert Duncan, Sergey Boldarev
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Patent number: 8376946Abstract: A method for treating a medical pathology includes receiving a first set of acoustic radiation scattered by a volume of tissue containing at least a portion of the medical pathology and thereafter, changing a temperature of the volume of tissue. The method also includes thereafter, receiving a second set of acoustic radiation scattered by the volume of tissue and localizing the portion of the medical pathology from the first and second sets of received acoustic radiation. Localizing the portion of the medical pathology comprises identifying the medical pathology from differences in the first and second sets of received acoustic radiation resulting from the change in temperature. The method also includes insonifying the portion of the medical pathology with sufficient energy to damage the portion of the medical pathology.Type: GrantFiled: May 16, 2003Date of Patent: February 19, 2013Assignee: Barbara Ann Karamanos Cancer InstituteInventors: Peter J. Littrup, Nebojsa Duric, Earle Holsapple, III
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Publication number: 20120053575Abstract: A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.Type: ApplicationFiled: November 9, 2011Publication date: March 1, 2012Inventors: Alexei V. Babkin, Peter J. Littrup, William J. Nydam
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Publication number: 20120035602Abstract: A cryosurgical system adapted for treatment of fibroadenomas within the breast of a patient. The system includes cryoprobes and a control system which operates the cryoprobes to accomplish freezing in two stages, including a high power freeze and a low power freeze.Type: ApplicationFiled: June 9, 2011Publication date: February 9, 2012Inventors: Peter J. Littrup, Seth A. Stabinsky, Kevin Van Bladel, Lisa Zindel, Glenn Foy
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Patent number: 8087256Abstract: The methods and systems using supercritical fluids for cooling of objects with high thermal emissions are disclosed. The unique thermodynamic properties of supercritical fluids combined with microchannel cooling technology allow effective absorption of the waste heat and exclude “vapor lock”, “boiling crisis”, and other deficiencies of conventional two-phase liquid cooling.Type: GrantFiled: September 23, 2008Date of Patent: January 3, 2012Assignee: Cryomechanics, LLCInventors: Alexei V. Babkin, Robert V. Duncan, Anatoly I. Efremov, Peter J. Littrup