Abstract: In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.

Abstract: A glass substrate comprises: a first position, wherein a tensile stress of the glass substrate is insufficient to cause fragmentation of the glass substrate into small pieces upon fracture of the glass substrate; and a second position, wherein the glass substrate is bent relative to the first position, and wherein the tensile stress of the glass substrate is sufficient to cause fragmentation of the glass substrate into small pieces upon fracture of the glass substrate. The glass substrate can include a first surface and a second surface. In the first position, the first surface and the second surface of the glass substrate can be planar. In the second position, the first surface and the second surface of the glass substrate can be planar. The small pieces can be generally cubic. In the second position, the glass substrate can be bent uniaxially along a bend axis of the glass substrate.

Abstract: A method for determining the locations of components of a location-determining system in an environment, the method comprising: providing a surveying device comprising: (i) a ranging subsystem comprising a transmitter and a receiver configured to receive signals transmitted by the receiver and reflected off objects in the environment whereby a three-dimensional map of the shape of the environment can be generated; (ii) a communication subsystem configured for transmitting signals to the said components or detecting signals from the said components; moving the surveying device in the environment whilst operating the ranging subsystem and the communication subsystem; and causing one or more processors to: (i) form the said three-dimensional map of the environment; and (ii) correlate that map with data received by or from the sensors to determine the positions of the sensors.

Abstract: A disposable staining system is provided including an insertable module configured to receive a biological sample therein, the insertable module including a well in which the biological sample is positioned; and a staining cartridge configured to receive the insertable module including the biological sample therein, the insertable module being positioned in the staining cartridge. The insertable module has first and second inclined planes on opposing sides of an upper surface of the insertable module. A sled configured to receive the insertable module has corresponding first and second inclined planes on a bottom surface thereof. The first and second inclined planes of the insertable module and the first and second inclined planes of the sled are configured to transform horizontal movement of the insertable module into the staining cartridge into a vertical movement of the sled such that the sled is pushed upward.

Abstract: The invention relates to a rotary blood pump including a housing having an internal chamber, a blood inlet port and a blood outlet port, a rotor including a plurality of blades and being adapted to rotate within the chamber. The pump includes a bearing system for controlling the position of the rotor wherein the bearing system includes one or more permanent magnets embedded in the rotor and one or more electromagnetic field inducing means embedded in the housing. The magnets embedded in the rotor are influenced by the electromagnetic field inducing means embedded in the housing for controlling the position of the rotor relative to the internal chamber of the housing and for driving rotation of the impeller within the chamber of the housing.

Abstract: A method of making a glass includes batching constituents, including silica, alumina, boria, magnesia, quicklime, and strontia, where one or more of the constituents is from “dirty” raw material that includes a relatively large amount of sulfur. The method further includes melting and mixing the batch to make glass having sulfur content but free of blisters, suitable for high performance displays.

Abstract: Spacecraft servicing devices or pods and related methods may include a body configured to be deployed from a host spacecraft at a location adjacent a target spacecraft and at least one spacecraft servicing component configured to perform at least one servicing operation on the target spacecraft.

Abstract: The invention relates to a device for arranging a seal on a collecting tray of a drain, such as an outlet drain or shower drain, which device includes: a fixing plate for fixing under a collecting tray of a drain, which fixing plate has at least two straight edges lying at an acute angle, preferably an angle of 90 degrees. The fixing plate includes at least one fastening opening through which a fastening means such as a threaded end and nut can protrude for the purpose of fastening the fixing plate against a bottom of a collecting tray and a watertight, flexible membrane which is arranged with an edge zone on the fixing plate. The free part of the membrane is upright and extends substantially perpendicularly of the fixing plate.

Abstract: A medical device, including an implantable portion of the medical device, the implantable portion including at least one electrode, wherein the implantable portion is configured to, while implanted in a human, obtain data indicative of wear of the at least one electrode. In an exemplary embodiment, the medical device is a cochlear implant.

Abstract: A glass composition comprises: 50.0 mol % to 70.0 mol % SiO2; 10.0 mol % to 25.0 mol % Al2O3; 0.0 mol % to 5.0 mol % P2O3; 0.0 mol % to 10.0 mol % B2O3; 5.0 mol % to 15.0 mol % Li2O; 1.0 mol % to 15.0 mol % Na2O; and 0.0 mol % to 1.0 mol % K2O. The sum of all alkali oxides, R2O, present in the glass composition may be in the range from greater than or equal to 11.0 mol % to less than or equal to 23.0 mol %. The sum of Al2O3 and R2O present in the glass composition may be in the range from greater than or equal to 26.0 mol % to less than or equal to 40.0 mol %. The glass composition may satisfy the relationship ?0.1<(Al2O3?(R2O+RO))/Li2O<0.3.

Abstract: A liquid discharge head includes a discharge port through which a liquid is discharged, an element for discharging the liquid from the discharge port, a channel through which the liquid is supplied to the discharge port, and a film member that is provided so as to be in contact with the liquid in a liquid chamber in the channel. The film member has a corrugated structure in which a plurality of loop-shaped projecting portions and a plurality of loop-shaped recessed portions are alternately formed. When seen in a direction perpendicular to a plane of the film member, the corrugated structure has a loop shape having a linear portion.

Abstract: Glass-based articles comprise stress profiles providing improved fracture resistance. The glass-based articles herein provide high fracture resistance after multiple drops.

Abstract: A strengthened cover glass or glass-ceramic sheet or article as well as processes and systems for making the strengthened glass or glass-ceramic sheet or article is provided for use in consumer electronic devices. The process comprises cooling the cover glass sheet by non-contact thermal conduction for sufficiently long to fix a surface compression and central tension of the sheet. The process results in thermally strengthened cover glass sheets for use in or on consumer electronic products.

Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system use Spodoptera frugiperda insect cells (such as Sf9 or Sf21) as viral production cells (VPCs).

Abstract: A glass composition includes greater than or equal to 60 mol % to less than or equal to 66 mol % SiO2, greater than or equal to 14 mol % to less than or equal to 16 mol % Al2O3, greater than or equal to 7 mol % to less than or equal to 9 mol % Li2O, greater than or equal to 4 mol % to less than or equal to 6 mol % Na2O, greater than or equal to 0.5 mol % to less than or equal to 3 mol % P2O5, greater than or equal to 0.5 mol % to less than or equal to 6 mol % B2O3; and greater than 0 mol % to less than or equal to 1 mol % TiO2. The glass composition may have a fracture toughness of greater than or equal 0.75 MPa?m. A glass composition includes SiO2, Al2O3, Li2O, Na2O, P2O5, and B2O3, wherein a molar ratio of Li2O/Na2O is greater than or equal to 1.2 to less than or equal to 2.0, the glass has a liquidus viscosity in the range from greater than or equal to 50 kP to less than or equal to 75 kP, and the glass has a KIC fracture toughness greater than or equal to 0.75 MPa·m0.5.

Abstract: Systems and methods are disclosed for detecting certain online activities associated with a digital identity. A Digital Identity Network may be monitored for potentially fraudulent activities (such as new account openings and certain transactions) related to an enrolled User identification (User ID) without requiring personally identifying information (PII). Corresponding alerts may be generated and sent to inform the associated user of such suspicious activity so that fraudulent account access or transactions may be prevented.

Abstract: A microprocessor system comprises a vector computational unit and a control unit. The vector computational unit includes a plurality of processing elements. The control unit is configured to provide at least a single processor instruction to the vector computational unit. The single processor instruction specifies a plurality of component instructions to be executed by the vector computational unit in response to the single processor instruction and each of the plurality of processing elements of the vector computational unit is configured to process different data elements in parallel with other processing elements in response to the single processor instruction.

Abstract: Implementations disclosed herein may include receiving from a user a selection of at least one die, a package type, and at least one test condition; generating, using a processor, a product die configuration and a product package configuration using a predictive modeling module and the at least one die and the package type; generating a graphic design system file; generating a package bonding diagram; generating a product spice model of the discrete device product using a technology computer aided design module; generating, using a processor, one or more datasheet characteristics of the discrete device product with the product SPICE model; generating a product datasheet for the discrete device product using the graphic design system file; and using a second interface generated by a computing device to provide access to the graphic design system file, the package bonding diagram, the product datasheet, and the product SPICE model.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: The disclosed vehicle stands have a base, a top plate, and a mechanical stop on the top plate that hold a vehicle in a secure, suspended position above a surface, such as the ground or a floor. The top plate can be removable from the base. The base has two legs that extend away from the top plate. The top plate can be flat or contoured to compliment a shape of a vehicle resting upon it. The top plate can include additional securing elements, such as a friction that on a surface that contacts a suspended vehicle and a locking mechanism that attaches to the suspended vehicle. Multiple vehicle stands can be used together. Two of the multiple stands can be connected by a cross-bar that extends under the vehicle as it is suspended above the surface by the two respective top plates.