Abstract: A piste grooming vehicle having at least one piste grooming device for preparing a piste. The piste grooming vehicle has a detection device configured to detect an actual topography of a piste section, positioned in front of the piste grooming vehicle in the forward travel direction thereof, of the piste, a determining device connected to the detection device and configured to determine at least one differential value between coordinates of the actual topography and coordinates of a reference topography of the piste, and a control device connected to the determining device and configured to actuate the at least one piste grooming device in accordance with the at least one determined differential value.

Abstract: The invention relates to a piste grooming vehicle having at least one piste grooming device for preparing a piste and to a method for operating such a piste grooming vehicle. Use in grooming ski pistes or snowboard pistes.

Abstract: A method for representing virtual information in a view of a real environment comprises providing a virtual object having a global position and orientation with respect to a geographic global coordinate system, with first pose data on the global position and orientation of the virtual object, in a database of a server, taking an image of a real environment by a mobile device and providing second pose data as to at which position and with which orientation with respect to the geographic global coordinate system the image was taken. The method further includes displaying the image on a display of the mobile device, accessing the virtual object in the database and positioning the virtual object in the image on the basis of the first and second pose data, manipulating the virtual object or adding a further virtual object, and providing the manipulated virtual object with modified first pose data or the further virtual object with third pose data in the database.

Abstract: A system for identification of a biological structure present in a liquid biopsy sample is provided. The system identifies common biological structures and rare biological structures based on their fluorescence characteristics and morphology. The identified biological structures may be used in diagnosis and treatment of a human afflicted with a disease. Examples described in this disclosure also relate to methods and assays that may be used together with the systems of this disclosure for diagnosis and treatment of a human afflicted with a disease.

Abstract: Wavefront sensors are provided herein. An aperture mask is configured to receive incident light the wavefront of which is to be measured and comprising irregularly spaced apertures that respectively transmit sub-beams of the incident light. A diffuser is configured to receive the sub-beams transmitted by irregularly spaced apertures of the aperture mask. A camera, having a focal plane in which the diffuser substantially is located, is configured to obtain a digital image of the diffuser and thus to obtain a digital image of the incident light the sub-beams of which the aperture mask transmits onto the diffuser. A controller is configured to electronically receive the digital image of the diffuser and to measure the wavefront of the incident light based on the digital image. Methods also are provided.

Abstract: A compensating element having a first and a second assembly, wherein a locking mechanism is provided which can be switched over between a first and a second operating state. In the first operating state, the first assembly is connected fixedly to the second assembly and, in the second operating state, the first and second assemblies are connected to each other via a spring mechanism in such a manner that they are movable relative to each other. The locking mechanism includes an electric motor that can be used to switch over between the first and the second operating state. A locking ring is or is not braced against at least three balls depending on its rotational position with respect to a center axis. The locking ring is connected in terms of rotary drive to the electric motor via a torsion spring which is elastic with respect to the center axis.

Abstract: The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters.

Abstract: The present invention provides methods for diagnosing lung cancer in a subject comprising (a) generating circulating tumor cell (CTC) data from a blood sample obtained from the subject based on a direct analysis comprising immunofluorescent staining and morphological characteristics of nucleated cells in the sample, wherein CTCs are identified in context of surrounding nucleated cells based on a combination of the immunofluorescent staining and morphological characteristics; (b) obtaining clinical data for the subject; (c) combining the CTC data with the clinical data to diagnose lung cancer in the subject.

Abstract: The invention provides seminal computational approaches utilizing data from non-rare cells to detect rare cells, such as circulating tumor cells (CTCs). The invention is applicable at two distinct stages of CTC detection; the first being to make decisions about data collection parameters and the second being to make decisions during data reduction and analysis. Additionally, the invention utilizes both one and multi-dimensional parameterized data in a decision making process.

Abstract: Methods, systems, and apparatus for a method that predicts an individual survival survival time of a patient. The method includes obtaining clinical data associated with health factors of the patient. The method includes obtaining liquid biopsy data associated with one or more attributes of diseased cells within the patient. The method includes predicting or determining a survival time of the patient using a deep learning model based on the clinical data and the liquid biopsy data. The method includes providing or outputting the survival time.

Abstract: The disclosure provides methods for detecting circular endothelial cells (CECs) in a non-enriched blood sample. The present disclosure is based, in part, on the unexpected discovery that CECs can be detected in non-enriched blood samples. The present disclosure is further based, in part, on the discovery that CECs can be detected in non-enriched blood samples by combining the detection of one or more immunofluorescent markers in the nucleated cells of a non-enriched blood sample with an assessment of the morphology of the nucleated cells. The present disclosure is further based, in part, on the discovery that CECs can be detected in non-enriched blood samples by comparing the immunofluorescent marker staining and morphological characteristics of CECs with the immunofluorescent marker staining and morphological characteristics of WBCs. The methods disclosed herein serve to classify human subject in myocardial infarction (MI) patients or healthy controls.

Abstract: This disclosure relates to a system for determining a quantitative health-related performance status of a patient. This disclosure further relates to a health assessment method for quantitative determination of health-related performance or quality of life of a patient. More specifically, this disclosure relates to systems and methods for determining whether a cancer patient will need unplanned medical care during cancer therapy. This system may comprise at least one sensor and at least one processor. The system may be configured to generate at least one output signal conveying physical activity information corresponding to physical activity of the patient, or spatial position information corresponding to at least one spatial position of an anatomical site of the patient while the patient performs a movement. The system may further be configured to determine a quantitative health-related performance score of the patient based on the physical activity parameter or the kinematic parameter.

Abstract: Human performance is a predictor of survival and response to chemotherapy in patients with cancer. It may be used to initiate new treatment, and monitor patients during ongoing treatment for early signs of deterioration when additional support can still be provided to restore performance and optimize treatment outcomes. This disclosure describes systems and methods for determining whether a cancer patient will need unplanned medical care during cancer therapy (e.g., necessitated by deterioration during cancer therapy). The systems and methods described herein are configured such that the determination is based on an acceleration of patient's center of mass during a prescribed movement, and/or metabolic equivalence determined based on the tracking of a patient's daily activities.

Abstract: The present invention provides methods for identifying circulating melanoma cells (CMCs) in a biological sample and methods for diagnosing metastatic melanoma in a subject. The methods disclosed can be used on non-enriched blood samples to identify CMC using detectable agents that are specific for a biomarker of CMCs and assessing the morphology of the cells having the detectable agents. The presence or absence of a detectable agent in combination with morphological characteristics of the cells can be used diagnose a subject with metastatic melanoma based on the number of CMCs is present in the sample.

Abstract: Methods are provided for detecting circulating tumor cells in a mammalian subject. Methods of diagnosing cancer in a mammalian subject are provided. The methods of detection or diagnosis indicate the presence of metastatic cancer or early stage cancer.

Abstract: The present invention provides methods for diagnosing lung cancer in a subject comprising (a) generating circulating tumor cell (CTC) data from a blood sample obtained from the subject based on a direct analysis comprising immunofluorescent staining and morphological characteristics of nucleated cells in the sample, wherein CTCs are identified in context of surrounding nucleated cells based on a combination of the immunofluorescent staining and morphological characteristics; (b) obtaining clinical data for the subject; (c) combining the CTC data with the clinical data to diagnose lung cancer in the subject.

Abstract: The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters.

Abstract: A device includes an antenna array with at least four antennas, wherein each antenna has its own feeder line terminal, wherein the feeder line terminals of antennas arranged directly adjacent to one another are geometrically offset from one another by 90° in each case. The device further includes a control device configured to feed the individual antennas via their respective feeder line terminals such that the antenna array exhibits different radiation patterns at different points in time. A first radiation pattern shows a polarized field distribution. According to the invention, a second radiation pattern exhibits an unpolarized field distribution.

Abstract: Methods, systems, and apparatus for a method that predicts an individual survival survival time of a patient. The method includes obtaining clinical data associated with health factors of the patient. The method includes obtaining liquid biopsy data associated with one or more attributes of diseased cells within the patient. The method includes predicting or determining a survival time of the patient using a deep learning model based on the clinical data and the liquid biopsy data. The method includes providing or outputting the survival time.

Abstract: A transceiver for distance measurements between the transceiver and an apparatus is provided. The transceiver has a transmitter configured to emit a first signal portion to be emitted at a first center frequency and a second signal portion to be emitted at a second center frequency so that the first signal portion to be emitted is radiated back from the apparatus to the transceiver as a first reflected signal portion and so that the second signal portion to be emitted is radiated back from the apparatus to the transceiver as a second reflected signal portion. In addition, the transceiver has a receiver configured to receive the first reflected signal portion radiated back from the apparatus to the transceiver and the second reflected signal portion radiated back from the apparatus to the transceiver. Furthermore, the transceiver has a measuring module configured to determine a distance between the transceiver and the apparatus.