Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.

Abstract: The invention relates to a quick set-up system for calibration devices located downstream from an extruder, in particular one for synthetic profiles. With this quick set-up system, a dry gauge and the vacuum tank(s) are mounted on two horizontally positioned tubes that are positively connected to the calibration stage, such that they can be moved and adjusted horizontally and vertically, which enables an exact advance adjustment of the gliding device, and with it, of the vacuum tanks and calibration device, thus eliminating a subsequent alignment. In addition, by installing a central water disposal system, the required replacement of hoses with different lengths when moving the vacuum tanks is avoided.

Abstract: The invention relates to a quick set-up system for calibration devices located downstream from an extruder, in particular one for synthetic profiles. With this quick set-up system, a dry gauge and the vacuum tank(s) are mounted on two horizontally positioned tubes that are positively connected to the calibration stage, such that they can be moved and adjusted horizontally and vertically, which enables an exact advance adjustment of the gliding device, and with it, of the vacuum tanks and calibration device, thus eliminating a subsequent alignment. In addition, by installing a central water disposal system, the required replacement of hoses with different lengths when moving the vacuum tanks is avoided.