Patents by Inventor Peter Lohse

Peter Lohse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of P38 and Methods of Using the Same
    Publication number: 20110301160
    Abstract: In general, the present invention relates to compounds capable of inhibiting p38 in vivo or in vitro, and methods for treating conditions associated with p38 activity or cytokine activity.
    Type: Application
    Filed: December 3, 2010
    Publication date: December 8, 2011
    Applicant: ARQULE, INC.
    Inventors: Mark A. ASHWELL, Syed ALI, Jifeng LIU, Yanbin LIU, Peter LOHSE, Belew MEKONNEN, Robert SELLIAH, Manish TANDON, Woj WRONA, Valery ANTONENKO
  • Inhibitors of P38 and methods of using the same
    Patent number: 7902192
    Abstract: In general, the present invention relates to compounds capable of inhibiting p38, methods for inhibiting p38 in vivo or in vitro, and methods for treating conditions associated with p38 activity or cytokine activity.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: March 8, 2011
    Assignee: ArQule, Inc.
    Inventors: Mark A. Ashwell, Syed Ali, Jifeng Liu, Yanbin Liu, Peter Lohse, Belew Mekonnen, Robert Selliah, Manish Tandon, Woj Wrona, Valery Antonenko
  • Peptide acceptor ligation methods
    Patent number: 7790421
    Abstract: Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: September 7, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Markus Kurz, Peter Lohse, Richard W. Wagner
  • DNA-protein fusions and uses thereof
    Publication number: 20080051299
    Abstract: Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
    Type: Application
    Filed: March 22, 2007
    Publication date: February 28, 2008
    Inventors: Peter Lohse, Markus Kurz
  • Inhibitors of P38 and Methods of Using the Same
    Publication number: 20070270418
    Abstract: In general, the present invention relates to compounds capable of inhibiting p38, methods for inhibiting p38 in vivo or in vitro, and methods for treating conditions associated with p38 activity or cytokine activity.
    Type: Application
    Filed: May 14, 2004
    Publication date: November 22, 2007
    Inventors: Mark Ashwell, Syed Ali, Jifeng Liu, Yanbin liu, Peter Lohse, Belew Mekonnen, Robert Selliah, Manish Tandon, Woj Wrona, Valery Antonenko
  • DNA-protein fusions and uses thereof
    Patent number: 7195880
    Abstract: Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: March 27, 2007
    Assignee: Adnexus Therapeutics, Inc.
    Inventors: Peter Lohse, Markus Kurz
  • Peptide acceptor ligation methods
    Publication number: 20060246549
    Abstract: Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products.
    Type: Application
    Filed: July 10, 2006
    Publication date: November 2, 2006
    Inventors: Markus Kurz, Peter Lohse, Richard Wagner
  • Peptide acceptor ligation methods
    Patent number: 7078197
    Abstract: Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: July 18, 2006
    Assignee: Compound Therapeutics, Inc.
    Inventors: Markus Kurz, Peter Lohse, Richard Wagner
  • In vitro protein interaction detection systems
    Patent number: 6951725
    Abstract: Disclosed herein are in vitro assays for the identification of interactions between proteins or other molecules, the identification of transcriptional activator proteins, and the detection of compounds that inhibit protein/protein or protein/compound interactions. Also disclosed herein are in vitro assays for the selection of interacting proteins and transcriptional activator proteins out of libraries.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: October 4, 2005
    Assignee: Compound Therapeutics, Inc.
    Inventors: Markus Kurz, Peter Lohse
  • C-terminal protein tagging
    Publication number: 20040198963
    Abstract: In general, the invention features proteins having covalently bonded C-terminal puromycin tags and methods for their production.
    Type: Application
    Filed: December 8, 2003
    Publication date: October 7, 2004
    Inventors: Peter Lohse, Michael McPherson, Robert G. Kuimelis
  • Methods for generating catalytic proteins
    Publication number: 20040166516
    Abstract: Disclosed herein are novel methods for the generation and identification of catalytic and autoproteolytic proteins using nucleic acid-protein fusion approaches.
    Type: Application
    Filed: December 1, 2003
    Publication date: August 26, 2004
    Inventors: Markus Kurz, Peter Lohse
  • C-terminal protein tagging
    Patent number: 6660473
    Abstract: In general, the invention features proteins having covalently bonded C-terminal puromycin tags and methods for their production.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: December 9, 2003
    Assignee: Phylos, Inc.
    Inventors: Peter Lohse, Michael McPherson, Robert G. Kuimelis
  • Methods for producing 5?-nucleic acid-protein conjugates
    Patent number: 6623926
    Abstract: Disclosed herein is a method for generating a 5′-nucleic acid-protein conjugate, the method involving: (a) providing a nucleic acid which carries a reactive group at its 5′ end; (b) providing a non-derivatized protein; and (c) contacting the nucleic acid and the protein under conditions which allow the reactive group to react with the N-terminus of the protein, thereby forming a 5′-nucleic acid-protein conjugate. Also disclosed herein are 5′-nucleic acid-protein conjugates and methods for their use.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: September 23, 2003
    Assignee: Phylos, Inc.
    Inventors: Peter Lohse, Martin C. Wright, Michael McPherson
  • Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules
    Patent number: 6602685
    Abstract: Disclosed herein is a method for detecting a compound-protein interaction, involving: (a) providing a compound library in which each member of the compound library is immobilized on a solid support; (b) contacting each member of the immobilized compound library in a single reaction chamber with each member of a protein-nucleic acid fusion library under conditions which allow the formation of compound-fusion complexes; (c) isolating the immobilized compound-fusion complexes; and (d) detecting a compound-fusion complex as an indication that the protein of the fusion interacts with the compound. In preferred embodiments, the protein is identified by reading the nucleic acid portion of the fusion, and the compound is identified by reading a detectable tag bound to either the compound or the solid support.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: August 5, 2003
    Assignee: Phylos, Inc.
    Inventor: Peter Lohse
  • Modular assembly of nucleic acid-protein fusion multimers
    Publication number: 20030027194
    Abstract: Described herein are methods and reagents for generating nucleic acid-protein fusion multimers, and methods for using such fusion molecule multimers to select an interaction between a protein or a peptide and a compound.
    Type: Application
    Filed: July 31, 2002
    Publication date: February 6, 2003
    Inventors: Markus Kurz, Peter Lohse
  • In vitro protein interaction detection systems
    Publication number: 20030013110
    Abstract: Disclosed herein are in vitro assays for the identification of interactions between proteins or other molecules, the identification of transcriptional activator proteins, and the detection of compounds that inhibit protein/protein or protein/compound interactions. Also disclosed herein are in vitro assays for the selection of interacting proteins and transcriptional activator proteins out of libraries.
    Type: Application
    Filed: June 20, 2002
    Publication date: January 16, 2003
    Inventors: Markus Kurz, Peter Lohse
  • Peptide acceptor ligation methods
    Publication number: 20020182687
    Abstract: Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products.
    Type: Application
    Filed: July 30, 2002
    Publication date: December 5, 2002
    Inventors: Markus Kurz, Peter Lohse, Richard Wagner
  • DNA-protein fusions and uses thereof
    Publication number: 20020177158
    Abstract: Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
    Type: Application
    Filed: June 26, 2002
    Publication date: November 28, 2002
    Inventors: Peter Lohse, Markus Kurz
  • Peptide acceptor ligation methods
    Patent number: 6429300
    Abstract: Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: August 6, 2002
    Assignee: Phylos, Inc.
    Inventors: Markus Kurz, Peter Lohse, Richard Wagner
  • DNA-protein fusions and uses thereof
    Patent number: 6416950
    Abstract: Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: July 9, 2002
    Assignee: Phylos, Inc.
    Inventors: Peter Lohse, Markus Kurz