Abstract: A holder for an inhaler article. The holder comprises a housing comprising a housing cavity. The holder further comprises an engagement member located at least partially within the housing cavity. The engagement member is movable relative to the housing between an upstream position and a downstream position. The engagement member comprised a first follower member. The housing comprises a first guide and a first latch, the first follower member is arranged to follow the first guide between a first position, a second position, and a third position. The first latch is arranged such that the first follower member may pass from the first position to the second position, but may not return to the first position without first passing the third position. An inhaler system comprises a holder and an inhaler article.

Abstract: A holder for an inhaler article that includes a sleeve positioned within a housing cavity, a piercing element, and a lockout mechanism. The sleeve comprises a sleeve cavity arranged to receive the inhaler article. The sleeve is movable within the housing cavity between a first and second position. The piercing element is arranged to pierce the inhaler article received within the sleeve when the sleeve is moved from the first position to the second position. The lockout mechanism comprises a guide, a follower member coupled to the sleeve, and a retaining section. The follower member is arranged to move along the guide into the retaining section as the sleeve moves from the second position and back to the first position. The retaining section is arranged to hold the follower member when the sleeve has returned back to the first position, thus retaining the sleeve in the first position.

Abstract: The invention relates to the ovine embryo cell line HVO-156 (DSM ACC2440), or to cell lines derived therefrom, and to their use for preparing and propagating ovine adenoviruses, in particular recombinant ovine adenoviruses which are derived from the isolate OAV 287.

Abstract: The invention relates to the ovine embryo cell line HVO-156 (DSM ACC2440), or to cell lines derived therefrom, and to their use for preparing and propagating ovine adenoviruses, in particular recombinant ovine adenoviruses which are derived from the isolate OAV 287.

Abstract: The invention relates to a nonhuman helper-dependent virus vector for transferring nucleic acid sequences. Areas of application are medicine, veterinary medicine, biotechnology and genetic engineering.

Abstract: The invention concerns an adenovirus vector for liver specific gene thera fields of application in medicine are the treatment of gene defects and tumour diseases of the liver and molecular biology. The vector according to the invention is marked by the fact that a therapeutic gene is coupled with a liver-specific promoter consisting of enhancer elements of the hepatitis B virus and an enhancerless minimum promoter and is optionally surrounded by SAR elements wherein the promoter is inserted into the adenovirus genome.