Abstract: The invention is related to the normalization of thyroid hormone transport by modulation of 4F2hc, CD981c, and the 4F2hc-CD981c heterodimer. Approaches to identify compounds that modulate thyroid hormone disorders, methods of identifying agonists and antagonists that modulate thyroid hormone disorders, and methods of making pharmaceuticals that ameliorate a thyroid hormone disorder are described herein.

Abstract: The invention is related to the normalization of thyroid hormone transport by modulation of 4F2hc, CD98lc, and the 4F2hc-CD98lc heterodimer. Approaches to identify compounds that modulate thyroid hormone disorders, methods of identifying agonists and antagonists that modulate thyroid hormone disorders, and methods of making pharmaceuticals that ameliorate a thyroid hormone disorder are described herein.

Abstract: Apparatus is provided for protecting, transporting and dispensing standard rolls of sheet material having an open center core and an inner end bent to project obliquely into the open core to define a tang. An elongate mandrel is constructed so that it can be inserted into the open center core of a standardized roll. The mandrel end not first inserted has an abutment face for abutting the end of the roll. The mandrel includes a recess for receiving the tang. A housing which can be opened to allow a mandrel to be removed or inserted defines bearing means for the ends of the mandrel. The housing further defines a slot through which the end of a roll of material can be drawn out of the housing. The mandrel includes a cranking device by which it can be rotated.

Abstract: A wheel alignment gauge comprising a pair of beams, each adapted to be mounted on or located against a different one of a pair of vehicle wheels or axles for such wheels, each of the beams is provided with a pivoted arm at an end of the beam which projects beyond the outer circumference of the wheel and the arms are interconnected by an elastic link, each of said arms is provided with read-out means to give an indication of the angular position of the arm relative to the beams, and thereby of the angular mis-alignment (toe angle) between the plane of rotation of the vehicle wheels or plane of rotation about the axles for the wheels; the read-out means being adjustable relative to the associated pivoted arm in order to allow for the steering angle at which the "toe out on turns" of the wheel is measured and provide an accurate direct reading gauge.