Abstract: It is provided a vehicle seat comprising a seat base, a seat part which is arranged on the seat base and can be adjusted relative to the seat base, a backrest which is mounted on the seat base so as to be pivotable between an upright use position and a non-use position which is pivoted towards the seat part, and a coupling mechanism for coupling an adjustment movement of the seat part to a pivot movement of the backrest. In this case, a locking lever is provided which can be pivoted between a locking position and an unlocking position by means of the coupling mechanism, is in its locking position in the use position of the backrest and locks the backrest from pivoting into the non-use position, and can be pivoted from its locking position into its unlocking position.

Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

Abstract: An example binding assay includes a plurality of sub-regions, a plurality of synthetic compounds on beads, wherein each of the plurality of sub-regions includes one of the plurality of synthetic compounds, a biological target labeled with a first detectable label in each of the plurality sub-regions, and a biological counter target labeled with a second detectable label in each of the plurality of sub-regions. The biological counter target is configured to bind to the biological target when the biological target is in a first orientation. And, wherein a first subset of the plurality of synthetic compounds bind to the biological target and effect interactions between the biological target and the biological counter target.

Abstract: The Artificial Intelligence engine can perform one or more operations. A query can be submitted to the Artificial Intelligence engine to search directly for a set of targeted properties for an unnamed molecule having the set of targeted properties. An indication of a structure of one or more candidate molecules found to have the set of targeted properties with the Artificial Intelligence engine is generated by applying one or more machine learning algorithms. The indication of the structure of the one or more candidate molecules found to satisfy the set of targeted properties in 3-dimensional space is supplied to a user in response to the query for the set of targeted properties to the Artificial Intelligence engine.

Abstract: Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. An example method includes using logic circuitry to: select a plurality of molecules that include a plurality of subgroups, each of the plurality of molecules exhibiting a mass spectrometry characteristic that is distinguishable from mass spectrometry characteristics of other molecules of the plurality, and assign the plurality of molecules with a position in a sequence of a plurality of synthetic compounds forming a library. The method further includes defining, as data in a memory circuit of the logic circuitry, the plurality of synthetic compounds that are sequenceable via mass spectrometry using the assigned positions of the plurality of molecules for communicating to other circuitry for formation thereof via coupling chemistry or screening of a particular function.

Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

Abstract: Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. A polymer bead, in accordance with embodiments, has an interior surface and an exterior surface that are topologically segregated from one another. The interior surface includes a protecting group and the exterior surface includes a deprotected group, which can also be referred to as a deprotected functional group. The protecting group can includes a nitrobenzenesulfonamide group that protects an amine group.

Abstract: Benzotriazine doxides are disclosed as drugs targeting mycobacterium tuberculosis, including novel compounds of formula I:

Abstract: Benzotriazine doxides are disclosed as drugs targeting mycobacterium tuberculosis, including novel compounds of formula I:

Abstract: An aminocoumarin conjugated to a fluorescent label through a secondary amine, is operative as a fluorescent polarization probe of the DNA gyrase B or topoisomerase IV E subunit. The probe is used for detecting topoisomerase inhibitor binding by fluorescence polarization, particularly in a high-through put topoisomerase inhibitor assay.

Abstract: Benzotriazine doxides are disclosed as drugs targeting mycobacterium tuberculosis, including novel compounds of formula I:

Abstract: An aminocoumarin conjugated to a fluorescent label through a secondary amine, is operative as a fluorescent polarization probe of the DNA gyrase B or topoisomerase IV E subunit. The probe is used for detecting topoisomerase inhibitor binding by fluorescence polarization, particularly in a high-through put topoisomerase inhibitor assay.