Patents by Inventor Peter McDonnell

Peter McDonnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of substituted thiazoline carboxylic acids
    Publication number: 20060217561
    Abstract: A useful and efficient method of preparing an alkylated thiazoline carboxylic acid, or a derivative thereof, comprises coupling a substituted aryl nitrile such as, for example, 2,4-dimethoxybenzonitrile or 4-methoxybenzonitrile, with a cysteine ester to form a substituted thiazoline carboxylic acid ester; optionally hydrolyzing the substituted thiazoline carboxylic acid ester to form a substituted thiazoline carboxylic acid; optionally, protecting the carboxyl group; alkylating the thiazoline ring at the 4-carbon position, as indicated in Structural Formula (I), with a compound of the formula R1-L, wherein R1 is as defined above and L is a leaving group, in the presence of a phase transfer catalyst; and, optionally, deprotecting the carboxyl group. In one embodiment of the present invention, a cinchona-alkaloid derived phase transfer catalyst is used to alkylate a protected substituted thiazoline carboxylic acid.
    Type: Application
    Filed: October 3, 2005
    Publication date: September 28, 2006
    Inventors: Mukund Chorghade, Rayomand Gimi, Peter McDonnell, Paul Wolstenholme-Hogg
  • Thrombopoiesis-stimulating proteins having reduced immunogenicity
    Publication number: 20040121953
    Abstract: The present invention relates to variant thrombopoietin proteins that possess thrombopoiesis-stimulating activity and have reduced immunogenicity. In particular, variants of thrombopoietin with reduced ability to bind one or more human class II MHC molecules are described.
    Type: Application
    Filed: August 11, 2003
    Publication date: June 24, 2004
    Inventors: Arthur J. Chirino, Jamal El Yazal, Shannon Alicia Marshall, Peter McDonnell, Jost Vielmetter
  • Topical compositions for the eye comprising a .beta.-cyclodextrin derivative and a therapeutic agent
    Patent number: 5494901
    Abstract: A topical composition comprising an amount of a carbonic anhydrase inhibitor and an amount of .beta.-cyclodextrin derivative effective in increasing the bioavailability of the carbonic anhydrase inhibitor when coadministered topically to the eye.
    Type: Grant
    Filed: January 5, 1993
    Date of Patent: February 27, 1996
    Inventors: Jonathan C. Javitt, Norman B. Javitt, Peter McDonnell
  • Process for purifying pentostatin
    Patent number: 5463035
    Abstract: A process for purifying pentostatin from a crude fermentation beer comprising the steps of 1) applying the fermentation beer to a strong cation exchange resin; 2) eluting with ammonium hydroxide; 3) concentrating the eluate; 4) applying the concentrated eluate to a strongly basic anion exchange resin charged with borate ion; 5) eluting with water; 6) applying this eluate to styrene-divinylbenzene beads prewashed with ethanol; 7) eluting the beads with water; and 8) recrysllyzing the pentostatin from water and methanol to yield a product that is greater than 99.7% pure.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: October 31, 1995
    Assignee: Warner-Lambert Company
    Inventors: James C. French, Colin R. Edmunds, Peter McDonnell, Howard D. H. Showalter
  • Topical compositions for the eye comprising a .beta.-cyclodextrin derivative and a therapeutic agent
    Patent number: 5418225
    Abstract: A topical composition comprising an amount of a carbonic anhydrase inhibitor and an amount of .beta.-cyclodextrin derivative effective in increasing the bioavailability of the carbonic anhydrase inhibitor when coadministered topically to the eye.
    Type: Grant
    Filed: January 5, 1993
    Date of Patent: May 23, 1995
    Inventors: Jonathan C. Javitt, Norman B. Javitt, Peter McDonnell