Abstract: Embodiments described herein are generally directed to a controller of a managed container service that facilitates selection among bare metal machines available within a private cloud. According to an example, a request is received by a Container-as-a-Service controller from a CaaS portal to create a cluster based at least in part on resources of a private cloud of a customer of a managed container service. An inventory of bare-metal machines available within the private cloud is received from a Bare-Metal-as-a-Service (BMaaS) provider associated with the private cloud. A particular bare metal machine is identified for the cluster by selecting among the available bare-metal machines based on cluster information associated with the request, the inventory, and a best fit algorithm configured in accordance with a policy established by the customer.

Abstract: Embodiments described herein are generally directed to a controller of a managed container service that facilitates autoscaling based on bare metal machines available within a private cloud. According to an example, a CaaS controller of a managed container service monitors a metric of a cluster deployed on behalf of a customer within a container orchestration system. Responsive to a scaling event being identified for the cluster based on the monitoring and an autoscaling policy associated with the cluster, a BMaaS provider associated with the private cloud may be caused to create an inventory of bare-metal machines available within the private cloud. Finally, a bare metal machine is identified to be added to the cluster by selecting among the bare-metal machines based on the autoscaling policy, the inventory and a best fit algorithm configured in accordance with a policy established by or on behalf of the customer.

Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: A positioning guide system for guiding a surgical tool comprising a positioning guide and a user interface. The positioning guide comprising: an interface to correspond to a plurality of anatomic landmarks of a patient; a plurality of sensors to provide an output indicative of the proximity of the interface and one or more of the plurality of anatomic landmarks; and a tool guide, for a surgical tool, positioned relative to the interface. The user interface provides a user output indicative of correct positioning of the positioning guide and the anatomic landmarks of the patient based on the output of the plurality of sensors.

Abstract: A tissue scanning system (1) comprising: a depth sensor (13) configured to determine distance to a surface; a pointer device (11), wherein the depth sensor (13) is mounted to the pointer device (11); a camera-based tracking system (3) configured to determine (114) relative orientation and position between an anatomical feature (9) and the pointer device (11); and at least one processing device (6). The processing device (6) is configured to: generate (116) a surface point cloud (16) of a surface (17) associated with the anatomical feature (9) based on a plurality of determined distances from the depth sensor (13) and corresponding relative orientation and position of the pointer device (11) relative to the anatomical feature (9).

Abstract: A system and method (100) for estimating range of motion of a joint (3) connecting a first bone (5) to a second bone (7), the joint comprising a point of rotation (9) defining rotation of the first bone relative to the second bone. The method comprises: obtaining (110) a digital model of the joint that includes, for each bone (5, 7), respective mesh models with sets of mesh points that represent the bone; determining (120) polar coordinates for the set of mesh points, with the point of rotation (9) as a pole (21) of the polar coordinates; and calculating (130), based on the polar coordinates, multiple angular distance values relating to rotation of the joint, where the multiple angular distance values are indicative of an angular distance between points in the set of mesh points, and the angular distance being indicative of the range of motion of the joint.

Abstract: A positioning guide system for guiding a surgical tool comprising a positioning guide and a user interface. The positioning guide comprising: an interface to correspond to a plurality of anatomic landmarks of a patient; a plurality of sensors to provide an output indicative of the proximity of the interface and one or more of the plurality of anatomic landmarks; and a tool guide, for a surgical tool, positioned relative to the interface. The user interface provides a user output indicative of correct positioning of the positioning guide and the anatomic landmarks of the patient based on the output of the plurality of sensors.

Abstract: A surgical guide system for guiding a surgical tool, comprising a body which comprises a first contact surface profiled to locate with a first anatomical surface of a first bone; and a second contact surface profiled to locate with a second anatomical surface of a second bone; wherein the body is configured, for a specified functional position of the first bone relative to the second bone, to simultaneously: locate the first contact surface with the first anatomical surface; locate the second contact surface with the second anatomical surface; and receive, or guide, a first fastener to fasten to the first bone, wherein at least one of the body and/or the first fastener forms a first reference to guide a first surgical tool to the first bone.

Abstract: A surgical guide system for guiding a surgical tool, comprising a body which comprises a first contact surface profiled to locate with a first anatomical surface of a first bone; and a second contact surface profiled to locate with a second anatomical surface of a second bone; wherein the body is configured, for a specified functional position of the first bone relative to the second bone, to simultaneously: locate the first contact surface with the first anatomical surface; locate the second contact surface with the second anatomical surface; and receive, or guide, a first fastener to fasten to the first bone, wherein at least one of the body and/or the first fastener forms a first reference to guide a first surgical tool to the first bone.

Abstract: The disclosure discloses a wearable computing device (WCD) that would selectively and automatically activate a transceiver of the WCD for data transmission based on sensor data obtained from a sensor module of the \VCD. In some example, the sensor module may convert the physical movements of the WCD into sensor data. Then, a processor module of the WCD compares the sensor data to a predetermined pattern pre-stored in the memory. If the sensor data matches the predetermined pattern, the processor module activates the transceiver to receive/transmit data packets. If the sensor data does not match the predetermined pattern, the process goes back to the beginning, where the processor module monitors the movement of the WCD through the sensors.

Abstract: Systems, devices, methods, and software for presenting predefined subset of parameters for an industrial control device are disclosed herein. In an embodiment, a method comprises displaying a plurality of industrial application options, wherein each industrial application option of the industrial application options corresponds to a respective type of industrial application for which an industrial control device may be purposed. The method further comprises receiving a selection of one of the plurality of industrial application options.

Abstract: The disclosure discloses a wearable computing device (WCD) that would selectively and automatically activate a transceiver of the WCD for data transmission based on sensor data obtained from a sensor module of the \VCD. In some example, the sensor module may convert the physical movements of the WCD into sensor data. Then, a processor module of the WCD compares the sensor data to a predetern lined pattern pre-stored in the memory. If the sensor data matches the predetermined pattern, the processor module activates the transceiver to receive/transmit data packets. If the sensor data does not match the predetermined pattern, the process goes back to the beginning, where the processor module monitors the movement of the WCD through the sensors.

Abstract: The present disclosure relates to a method and system for configuring a surgical tool during surgery. A laser scanner generates sensor data and a processor determines spatial data indicative of a position of the anatomical feature and of a position of a tool interface that is fixed in relation to the anatomical feature based on the sensor data. The processor also determines a first desired spatial configuration of the surgical tool in relation to the tool interface based on the spatial data and a second desired spatial configuration of the surgical tool in relation to the anatomical feature. The outcome is more accurate and less complex than other methods, such as methods that are based on reference to the absolute positions of the anatomical feature and the surgical tool within an operation theatre.

Abstract: The disclosure discloses a wearable computing device (WCD) that would selectively and automatically activate a transceiver of the WCD for data transmission based on sensor data obtained from a sensor module of the WCD. In some example, the sensor module may convert the physical movements of the WCD into sensor data. Then, a processor module of the WCD compares the sensor data to a predetermined pattern pre-stored in the memory. If the sensor data matches the predetermined pattern, the processor module activates the transceiver to receive/transmit data packets. If the sensor data does not match the predetermined pattern, the process goes back to the beginning, where the processor module monitors the movement of the WCD through the sensors.

Abstract: Systems, methods, and software for presenting predefined parameter subsets for industrial automation devices and equipment are provided herein. In one example, a non-transitory computer readable medium having stored thereon program instructions executable by a computing device is presented. When executed by the computing device, the program instructions direct the computing device to present a graphical user interface with at least one predetermined subset of parameters, receive a user selection for one of the at least one predetermined subset of operating parameters for an industrial automation device, identify parameters associated with the selected subset, and display the identified subset of parameters.

Abstract: Systems, devices, methods, and software for presenting predefined subset of parameters for an industrial control device are disclosed herein. In an embodiment, a method comprises displaying a plurality of industrial application options, wherein each industrial application option of the industrial application options corresponds to a respective type of industrial application for which an industrial control device may be purposed. The method further comprises receiving a selection of one of the plurality of industrial application options.

Abstract: The present disclosure relates to a method and system for configuring a surgical tool during surgery. A laser scanner generates sensor data and a processor determines spatial data indicative of a position of the anatomical feature and of a position of a tool interface that is fixed in relation to the anatomical feature based on the sensor data. The processor also determines a first desired spatial configuration of the surgical tool in relation to the tool interface based on the spatial data and a second desired spatial configuration of the surgical tool in relation to the anatomical feature. The outcome is more accurate and less complex than other methods, such as methods that are based on reference to the absolute positions of the anatomical feature and the surgical tool within an operation theatre.

Abstract: A positioning guide system for guiding a surgical tool comprising a positioning guide and a user interface. The positioning guide comprising: an interface to correspond to a plurality of anatomic landmarks of a patient; a plurality of sensors to provide an output indicative of the proximity of the interface and one or more of the plurality of anatomic landmarks; and a tool guide, for a surgical tool, positioned relative to the interface. The user interface provides a user output indicative of correct positioning of the positioning guide and the anatomic landmarks of the patient based on the output of the plurality of sensors.

Abstract: There is provided a method (100) for aligning and positioning an implant (305). The method (100) comprises creating a reference using a guide (500) configured in accordance with patient specific data; fixing the reference using a reference marker (920) and delivering the implant (305) with an impactor (1005) aligned in accordance with the reference. Guide light emission means (515a) may be employed to create the reference, reference marker light emission means (515b) may be employed to fix the reference and impactor light emission means (515c) may be employed to align an impactor (1005).

Abstract: The disclosure discloses a wearable computing device (WCD) that would selectively and automatically activate a transceiver of the WCD for data transmission based on sensor data obtained from a sensor module of the WCD. In some example, the sensor module may convert the physical movements of the WCD into sensor data. Then, a processor module of the WCD compares the sensor data to a predetermined pattern pre-stored in the memory. If the sensor data matches the predetermined pattern, the processor module activates the transceiver to receive/transmit data packets. If the sensor data does not match the predetermined pattern, the process goes back to the beginning, where the processor module monitors the movement of the WCD through the sensors.