Abstract: An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellets, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferably pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of each plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestinal tract.

Abstract: Water is used to control particle size in a process comprising mixing water with a composition comprising a rheology modifying agent and possibly sugar and cellulose to produce a paste. The paste is extruded to form particles which are then spheronised and dried. One advantage of using water to control particle size is that the number of particles having a diameter within a required range, e.g. between from about 800 to about 1500 ?m, may be increased.

Abstract: Water is used to control particle size in a process comprising mixing water with a composition comprising a rheology modifying agent and possibly sugar and cellulose to produce a paste. The paste is extruded to form particles which are then spheronised and dried. One advantage of using water to control particle size is that the number of particles having a diameter within a required range, e.g. between from about 800 to about 1500 ?m, may be increased.

Abstract: An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellets, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferably pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of each plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestinal tract.

Abstract: Water is used to control particle size in a process comprising mixing water with a composition comprising a rheology modifying agent and possibly sugar and cellulose to produce a paste. The paste is extruded to form particles which are then spheronised and dried. One advantage of using water to control particle size is that the number of particles having a diameter within a required range, e.g. between from about 800 to about 1500 ?m, may be increased.

Abstract: An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellets, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferably pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of each plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestinal tract.

Abstract: Water is used to control particle size in a process comprising mixing water with a composition comprising a rheology modifying agent and possibly sugar and cellulose to produce a paste. The paste is extruded to form particles which are then spheronised and dried. One advantage of using water to control particle size is that the number of particles having a diameter within required range, e.g. between from about 800 to about 1500 ?m, may be increased.

Abstract: An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellets, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferably pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of each plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestinal tract.

Abstract: A material stability test kit (50) has a container (51) which can be closed and sealed by a screw-on cover (52) after insertion of a test sample (26) together with a chemical humidifier (53) for generating a desired humidity within the container (51). The container (51) is of two part construction comprising an outer container (54) within which is nested a smaller inner container (55) supporting the test sample (26). The containers (54, 55) are of transparent material to allow viewing and inspection of the test sample (26) without removing the test sample from the container (51) which would disturb the desired climate condition generated within the container (51) by the humidifier (53). The humidifier (53) comprises a perforated receptacle (80) containing a saturated or non-saturated salt solution.

Abstract: A material stability test system has a plurality of sealed test containers mounted in an environmental chamber. Each container has means for generating a desired humidity within the container. The environmental chamber is operable to provide a desired temperature within the environmental chamber. A test sample is mounted in each container. A sensor unit on each container senses the temperature and humidity within the container. An associated datalogger unit on each container connected to the sensor unit collects and transmits sensed temperature and humidity data at timed intervals via radio link to a remote monitoring station including a PC for recordal and/or display.

Abstract: A storage-stable combination of at least one &bgr;-lactam antibiotic and at least one &bgr;-lactam inhibitor compressed into tablet form having a hardness of greater than 30 KP is disclosed.

Abstract: A dry powder formulation of antibiotic and .beta.-lactam inhibitor is provided which is suitable for use in a liquid suspension.