Abstract: Compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein the substituents are defined in the specification. The compounds are hyperpolarisation activated cyclic-nucleotide modulated ion channel 2 (HCN2) inhibitors. Also disclosed are pharmaceutical compositions comprising the compounds, and the use of the compounds for the treatment or prevention of medical conditions mediated by HCN2, including neuropathic pain.

Abstract: Compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are defined in the specification. The compounds are hyperpolarisation activated cyclic-nucleotide modulated ion channel 2 (HCN2) inhibitors. Also disclosed are pharmaceutical compositions comprising the compounds, and the use of the compounds for the treatment or prevention of medical conditions mediated by HCN2, including neuropathic pain.

Abstract: Vaccine compositions comprising at least one modified immunogen via in vitro glycosylation methods that provide a rational approach for generating glycosylated versions of immunogens via the reducing end of a linear carbohydrate, the reducing end containing an N-acyl-2-amino moiety. Vaccine compositions comprising a plurality of heterologous immunogens associated with a multivalent carrier, wherein at least one immnunogen is glycosylated. Vaccine compositions comprising multivalent carriers and related methods using the vaccine compositions in various therapeutic and prophylactic applications for inducing an immune response against, treating, or preventing a bacterial, viral, fungal, or protozoan infection.

Abstract: The oral training device for muscles of the throat and/or face includes a panel which is receivable in the oral cavity formed between the lips and teeth. The panel has a first face adjacent to the lip area and an opposite second face being adjacent to the teeth and/or gums when in use. The device includes a handle which projects outwardly from the first face for applying an outward pulling force to the panel generally away from the oral cavity. The device also includes an elongate platform extending laterally across the first face onto which the upper and lower lips are placeable when in use.

Abstract: The oral training device for muscles of the throat and/or face includes a panel which is receivable in the oral cavity formed between the lips and teeth. The panel has a first face adjacent to the lip area and an opposite second face being adjacent to the teeth and/or gums when in use. The device includes a handle which projects outwardly from the first face for applying an outward pulling force to the panel generally away from the oral cavity. The device also includes an elongate platform extending laterally across the first face onto which the upper and lower lips are placeable when in use.

Abstract: Systems and methods for treating water are provided. The systems and methods may utilize an electrochemical water treatment device comprising ion exchange membranes. In certain systems and methods, a concentrate stream and a dilution stream may be in fluid communication with ion exchange membranes. The ion exchange membranes may be configured to provide a ratio of a pH of the concentrate stream and a pH of the dilution stream to be less than about 1.0. In some instances, the LSI of the concentrate stream may be less than or about 1.0. In certain instances, the electrochemical water treatment device does not require a reverse polarity cycle.

Abstract: Systems and methods for treating water are provided. The systems and methods may utilize an electrochemical water treatment device comprising ion exchange membranes. In certain systems and methods, a concentrate stream and a dilution stream may be in fluid communication with ion exchange membranes. The ion exchange membranes may be configured to provide a ratio of a pH of the concentrate stream and a pH of the dilution stream to be less than about 1.0. In some instances, the LSI of the concentrate stream may be less than or about 1.0. In certain instances, the electrochemical water treatment device does not require a reverse polarity cycle.

Abstract: Systems and methods for treating water are provided. The systems and methods may utilize an electrochemical water treatment device comprising ion exchange membranes. In certain systems and methods, a concentrate stream and a dilution stream may be in fluid communication with ion exchange membranes. The ion exchange membranes may be configured to provide a ratio of a pH of the concentrate stream and a pH of the dilution stream to be less than about 1.0. In some instances, the LSI of the concentrate stream may be less than or about 1.0. In certain instances, the electrochemical water treatment device does not require a reverse polarity cycle.

Abstract: Systems and methods for treating water are provided. In certain examples, the water to be treated is seawater. The systems and methods may utilize an electrochemical water treatment device comprising ion exchange membranes. In at least one example, the electrochemical water treatment device may be configured to perform a desalination process on seawater. In some examples, the ion exchange membranes may be configured to provide a ratio of a pH of the concentrate stream and a pH of the dilution stream to be in a range of from about 0.9 to about 1.2.

Abstract: Systems and methods for treating water are provided. The systems and methods may utilize an electrochemical water treatment device comprising ion exchange membranes. In certain systems and methods, a concentrate stream and a dilution stream may be in fluid communication with ion exchange membranes. The ion exchange membranes may be configured to provide a ratio of a pH of the concentrate stream and a pH of the dilution stream to be less than about 1.0. In some instances, the LSI of the concentrate stream may be less than or about 1.0. In certain instances, the electrochemical water treatment device does not require a reverse polarity cycle.

Abstract: A control system is configured to remotely read data associated with a process system in real time and perform various functions associated with the obtained data. The data may be stored to a database and/or analyzed to provide various operating parameters to one or more remote clients.