Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant adeno-associated virus (rAAV) particles. The production process and system use Baculoviral Expression Vectors (BEVs) and/or Baculoviral Infected Insect Cells (BIICs) in the production of AAV particles (e.g., rAAVs) which allow for the controlled expression of AAV structural (e.g., capsid) proteins, such as VP1, VP2, and VPS and the controlled expression of AAV nonstructural (e.g., replication) proteins, such as Rep78 and Rep52.

Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system use Spodoptera frugiperda insect cells (such as Sf9 or Sf21) as viral production cells (VPCs).

Abstract: An apparatus includes a shaft, an expandable dilator, and at least one ventilation pathway. The shaft defines a longitudinal axis and includes a distal and proximal ends with at least one shaft lumen. The expandable dilator includes body with its own proximal and distal ends. The body is configured to transition between a contracted state and an expanded state. The body is configured to dilate a Eustachian tube of a patient in the expanded state. The at least one ventilation pathway is configured to provide ventilation from the distal end of the body to the proximal end of the body when the body is in the expanded state. In some examples, the ventilation pathway includes a set of transversely oriented vent openings formed through the shaft. In some other examples, the ventilation pathway includes a space defined between one or more radially outwardly protruding features of the expandable dilator.

Abstract: Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.

Abstract: A system for glucaric acid production includes (a) a first input selected from the group consisting of glucuronolactone, a disaccharide feedstock, a cleaved starch, a disaccharide, glucuronic acid, or a combination thereof. In addition, the system includes (b) a first catalyst system comprising a metal oxidation catalyst; (c) a first product; (d) a second input. Further, the system includes (e) a second catalyst system comprising an enzyme. Still further, the system includes (f) a second product comprising from about 50% to about 99% glucaric acid on a dry basis.

Abstract: Methods and systems for training one or more neural networks for transcription and for transcribing a media file using the trained one or more neural networks are provided. One of the methods includes: segmenting the media file into a plurality of segments; inputting each segment, one segment at a time, of the plurality of segments into a first neural network trained to perform speech recognition; extracting outputs, one segment at a time, from one or more layers of the first neural network; and training a second neural network to generate a predicted-WER (word error rate) of a plurality of transcription engines for each segment based at least on outputs from the one or more layers of the first neural network.

Abstract: There is provided a cartridge for storing and dispensing liquid for use with an inkjet printer, the cartridge comprising: a collapsible reservoir enclosing an internal space for storage of the liquid, wherein: the reservoir comprises a first wall portion and a second wall portion, the first wall portion defining a first region of the internal space, the second wall portion defining a second region of the internal space, the first region and the second region being in fluid communication with each another; and the first wall portion and the second wall portion are configured such that at least a part of the second wall portion collapses more easily than the first wall portion when the liquid is withdrawn from the reservoir; an outlet configured to dispense the liquid; and a holder configured to receive an electronic data storage device, wherein the holder is provided on the first wall portion.

Abstract: A trickle bed reactor, comprising a plurality of catalyst beds connected in series and progressively increasing in catalyst mass in a direction from upstream to downstream; and a plurality of heat exchangers, wherein each of the heat exchangers is located between two of the plurality of catalyst beds, and wherein each of the heat exchangers does not exchange heat with an outer surface of a vessel that contains any of the catalyst beds.

Abstract: Methods and systems for training one or more neural networks for transcription and for transcribing a media file using the trained one or more neural networks are provided. One of the methods includes: segmenting the media file into a plurality of segments; inputting each segment, one segment at a time, of the plurality of segments into a first neural network trained to perform speech recognition; extracting outputs, one segment at a time, from one or more layers of the first neural network; and training a second neural network to generate a predicted-WER (word error rate) of a plurality of transcription engines for each segment based at least on outputs from the one or more layers of the first neural network.

Abstract: Provided herein are devices, systems, and methods for biological sample collection. In particular, provided herein are devices, systems, and methods that employ small, hand-held devices that collect small volumes of biological samples, such as vitreous from the eye, for diagnostic and other purposes.

Abstract: Provided is a semisolid softgel fill material that includes water and/or other polar solvents, along with a high amount of a nonpolar component, such as an oil. Also provided are methods and systems for producing softgels including the fill material. The softgels produced by the methods and systems provided herein have a normal appearance and retain their structural integrity, even when dried according to conventional methods. Further, when the fill material is added to water or other liquid, as it would be following ingestion, the fill material forms small droplets, thereby enhancing digestion and absorption of the fill material.

Abstract: Methods and systems for classifying a multimedia file using interclass data is disclosed. One of the methods includes receiving, from a first transcription engine, one or more transcription results of one or more audio segments of the multimedia file; identifying a first transcription result for a first audio segment having a low confidence of accuracy; identifying a first image data of the multimedia file corresponding to the first segment; receiving, from an image classification engine trained to classify image data, an image classification result of one or more portions of the first image data in response to requesting the image classification engine to classify the first image data; and selecting, based at least on the image classification result of the one or more portions of the first image data, a second transcription engine to re-classify the first audio segment.

Abstract: Provided herein are embodiments of systems and methods for classifying one or more objects in an image. One of the methods includes: receiving object classification results of the image from one or more classification engines, the object classification results comprise classification of one or more objects and confidence scores associated with the one or more objects; aggregating the object classification results from the one or more classification engines to generate a list of confidence scores associated with each of the one or more objects, the list of confidence scores comprises one or more confidence scores from one or more classification engines; calculating an overall certainty score for each of the one or more objects based at least on the list of confidence scores; and generating a first orchestrated classification result based the overall certainty score for each of the one or more object.

Abstract: Methods and systems for training one or more neural networks for transcription and for transcribing a media file using the trained one or more neural networks are provided. One of the methods includes: segmenting the media file into a plurality of segments; extracting, using a first neural network, audio features of a first and second segment of the plurality of segments; and identifying, using a second neural network, a best-candidate engine for each of the first and second segments based at least on audio features of the first and second segments. A best-candidate engine is a neural network having a highest predicted transcription accuracy among a collection of neural networks.

Abstract: An injectable peptide-based hydrogel is disclosed that incorporates a peptide inhibitor of proprotein convertase subtilisn/kexin type 9. The hydrogel is a polymer composed of the 13-amino-acid protein, Pep2-8, (TVFTSWEEYLDWV) attached to a self-assembling peptide of the ABA block structure (ESLSLSLSLSLSLEG) to generate the repeating multidomain peptide sequence (ESLSLSLSLSLSLEGTVFTSWEEYLDWV).

Abstract: Methods and systems for classifying a multimedia file using interclass data is disclosed. One of the methods can use classification results from one or more engines of different classes to select a different engine for the original classification task. For example, given an audio segment with associated metadata and image data, the disclosed interclass method can use the classification results from a topic classification of metadata and/or an image classification result of the image data as inputs for selecting a new transcription engine to transcribe the audio segment.

Abstract: A lottery ticket is printed on a substrate sheet material having a front surface with lottery game indicia printed thereon and a removable covering material, typically scratch-off material, covering the lottery game indicia which is removable by a player to expose the game indicia for playing the game and other game information printed on the substrate sheet material where at least part of the substrate sheet material is formed of a translucent synthetic material to enable viewing through the part by the player. In order to allow the ticket to be dispensed in a row of the tickets from a dispensing machine with an optical sensor, a patch of an opaque or semi-opaque material is applied onto the substrate at a location to cooperate with the sensor while it is operating to detect ticket location.

Abstract: Provided herein are methods and processes for emulsifying non-polar compounds, such as omega fatty acids. Also provided are compositions that can be prepared according to the methods and processes described herein. The compositions, for example, have a high amount of the non-polar compound, such as a large amount of omega fatty acids. The non-polar compounds are also present in very small droplets within composition. For example, the mean or median particle size of the droplets is less than about 5 ?m. Further, the composition includes a low amount of surfactant, such as less than about 10-15% of the surfactant.