Abstract: An anti-microbial polymeric film comprising a polymeric substrate layer having a first and second surface and on a surface thereof a coating having a thickness of from about 0.01 to about 14.0 gm and comprising an anti-microbial compound in an amount of from about 0.1 to about 50% by weight of the coating layer, characterised in that (i) said coating provides a heat-seal strength of from 100 g/in to 2500 g/in when heat-sealed to itself and/or (ii) said coating provides a barrier to water vapour and/or oxygen, such that the water vapour transmission rate is in the range of 0.01 to 10 g/100 inches2/day and the oxygen transmission rate is in the range of 0.01 to 10 cm3/100 inches2/day/atm.

Abstract: A composite structure suitable for making transdermal delivery devices includes in sequence: (a) a liner film layer; (b) a containment layer having from zero to 15 wt % content of vinyl acetate repeating units, the layer including either a thermal bonding copolyester resin or a combination of an ethylene-vinyl acetate component and a nonpolar polymer; and (c) a polyester film layer less than 20 ?m in thickness. A drug layer lies either between the liner film layer and the containment layer or within a concave depression in the containment layer. A composition including an ethylene-vinyl acetate component and an ABA block copolymer, wherein the A segments of the block copolymer are styrenic segments, is also provided. The composition includes between 1 and 15 wt % of vinyl acetate repeating units, based on the total weight of composition exclusive of any solvents.