Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a an agent that blocks Programmed Death-1 receptor (PD-1) and Programmed Death Ligand-1 (PD-L1) signaling and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, kits comprising the compositions and methods of use therefor.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a an agent that blocks Programmed Death-1 receptor (PD-1) and Programmed Death Ligand-1 (PD-L1) signaling and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, kits comprising the compositions and methods of use therefor.

Abstract: An absorbent article has a top sheet, a back sheet, and an absorbent assembly positioned between the back sheet and the top sheet. The absorbent article includes a fluid intake layer positioned between the absorbent assembly and the top sheet. The fluid intake layer has a rearward-facing arch located in a back portion of the fluid intake layer. The fluid intake layer has an opening. The absorbent article includes a first lateral stiffener and a second lateral stiffener extending along a majority of the longitudinal side edges of the fluid intake layer. The absorbent article includes a first flexure, a second flexure, and a third flexure in a rear portion of the absorbent article.

Abstract: An absorbent article has a top sheet, a back sheet, and an absorbent assembly positioned between the back sheet and the top sheet. The absorbent article includes a fluid intake layer positioned between the absorbent assembly and the top sheet. The fluid intake layer has a rearward-facing arch located in a back portion of the fluid intake layer. The fluid intake layer has an opening. The absorbent article includes a first lateral stiffener and a second lateral stiffener extending along a majority of the longitudinal side edges of the fluid intake layer. The absorbent article includes a first flexure, a second flexure, and a third flexure in a rear portion of the absorbent article.

Abstract: This disclosure relates to methods of treating cancer. This disclosure further relates to treating cancer in a subject with compounds that are inhibitors of PRMT5, particularly in combination with CDK4/6 inhibitors.

Abstract: This disclosure relates to methods of treating cancer. This disclosure further relates to treating cancer in a subject with compounds that are inhibitors of PRMT5, particularly in combination with KRASG12C inhibitors.

Abstract: The invention provides a stack comprising a plurality of absorbent sheets stacked in facing arrangement. The stack is bound along its top edge by at least one line of stitches comprising a plurality of spaced apart stitch holes and a thread disposed therein. Individual sheets further comprise a line of perforations comprising a plurality of spaced apart perforation holes. The line of stitches and the line of perforations are such that there is generally a one-to-one numerical correspondence amongst at least a majority of the plurality of stitch holes and perforation holes.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a CDK 4/6 inhibitor and a KRAS G12C inhibitor of Formula (I), Formula (I-A) or Formula (I-B), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: The invention relates to a stack of absorbent sheets, such as paper towels, toilet tissue, napkins, facial tissue and the like. The stack is sewn with a first line of stitching disposed adjacent to a first edge of the bound stack, such as the top edge. The stack further comprises a second line of stitches, which may be disposed adjacent to the first line of stitches. The second line of stitches comprises an unbalanced stitch to facilitate separation and removal of individual sheets.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a SHP-2 inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a pan ErbB family inhibitor and a KRAS G12C inhibitor of Formula (I), Formula (I-A) or Formula (I-B), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a Raf family kinase inhibitor and a KRAS G12C inhibitor of Formula (I), Formula (I-A) or Formula (I-B), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a mTOR inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a Src-family kinase inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: An absorbent article can have an improved attachment to a wearer's undergarment and can maintain proper placement in the undergarment of the wearer. The absorbent article can produce less waste for the wearer of the absorbent article. The absorbent article can have a topsheet layer, a backsheet layer, an absorbent core positioned between the topsheet layer and the backsheet layer, and a pair of opposing wings. The absorbent article can have a mechanical garment attachment which can maintain the placement of the absorbent article within the wearer's undergarment.

Abstract: The invention relates to a stack of absorbent sheets, such as paper towels, toilet tissue, napkins, facial tissue, and the like. The stack has a binding element that is compressed and sewn with a first line of stitching disposed adjacent to the first edge of the bound stack, such as the top edge. The binding element may be free from adhesives. The line of stitches facilitate separation and removal of individual sheets and may alleviate the need for perforations or a line of weakness.

Abstract: An absorbent article has a top sheet, a back sheet, and an absorbent assembly positioned between the back sheet and the top sheet. The absorbent article includes a fluid intake layer positioned between the absorbent assembly and the top sheet. The fluid intake layer has a rearward-facing arch located in a back portion of the fluid intake layer. The fluid intake layer has an opening. The absorbent article includes a first lateral stiffener and a second lateral stiffener extending along a majority of the longitudinal side edges of the fluid intake layer. The absorbent article includes a first flexure, a second flexure, and a third flexure in a rear portion of the absorbent article.

Abstract: Disclosed are stacks of absorbent sheets, such as paper towels, toilet tissue, napkins, facial tissue, and the like. The stacks generally comprise a plurality of absorbent sheets bound by compressing the sheets to form a binding element. The binding element is generally free from adhesives or mechanical fasteners, and acts to bind the sheets to one another and form the 5 stack. The binding element may be disposed along only a portion of the stack or may extend continuously across a first dimension of the stack Binding the stack in this manner generally results in individual sheets arranged in facing arrangement with one another without an adhesive disposed between them and as such the entire sheet may be used once it is dispensed from the stack.

Abstract: An absorbent article has a top sheet, a back sheet, and an absorbent assembly positioned between the back sheet and the top sheet. The absorbent article includes a fluid intake layer positioned between the absorbent assembly and the top sheet. The fluid intake layer has a rearward-facing arch located in a back portion of the fluid intake layer. The fluid intake layer has an opening. The absorbent article includes a first lateral stiffener and a second lateral stiffener extending along a majority of the longitudinal side edges of the fluid intake layer. The absorbent article includes a first flexure, a second flexure, and a third flexure in a rear portion of the absorbent article.

Abstract: The invention relates to a stack of absorbent sheets, such as paper towels, toilet tissue, napkins, facial tissue and the like. The stack is sewn with a first line of stitching disposed adjacent to a first edge of the bound stack, such as the top edge. The stack further comprises a second line of stitches, which may be disposed adjacent to the first line of stitches. The second line of stitches comprises an unbalanced stitch to facilitate separation and removal of individual sheets.