Patents by Inventor Peter Pöchlauer
Peter Pöchlauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220073958Abstract: The present invention relates to a process for biocatalytic amidation of non-protected amino acids comprising the step of contacting a non-protected amino acid with an ammonia source in the presence of an organic solvent and an enzyme.Type: ApplicationFiled: December 3, 2019Publication date: March 10, 2022Applicant: PATHEON AUSTRIA GMBH & CO KGInventors: Peter POECHLAUER, Philipp SELIG, Christopher ZINGANELL, Julia PITZER, Anton GLIEDER, Wolfgang KROUTIL, Kerstin STEINER
-
Patent number: 10843999Abstract: The invention pertains to a process for preparing a compound of formula (1) wherein R1 is independently chosen from C1-C6 alkyl, cycloalkyl, aralkyl and aryl, and R2, R3 and R4 are independently chosen from hydrogen and C1-C6 alkyl, cycloalkyl, aralkyl and aryl; which process comprises the steps of: a) contacting a compound of formula (2) wherein R1 and R2 are as above and M+ is a monovalent metal ion, with a compound of formula (3) wherein R3 and R4 are as above, to form a compound of formula (4) and b) followed by contacting the compound of formula (4) with an acid to give a compound of formula (1), wherein step (a) and/or step (b) are conducted in continuous mode.Type: GrantFiled: February 12, 2018Date of Patent: November 24, 2020Assignee: Patheon Austria GmbH & Co KGInventors: Paul Kohls, Peter Pöchlauer, Stefan Steinhofer, Christian Schuster
-
Publication number: 20200002263Abstract: The invention pertains to a process for preparing a compound of formula (1) wherein R1 is independently chosen from C1-C6 alkyl, cycloalkyl, aralkyl and aryl, and R2, R3 and R4 are independently chosen from hydrogen and C1-C6 alkyl, cycloalkyl, aralkyl and aryl; which process comprises the steps of: a) contacting a compound of formula (2) wherein R1 and R2 are as above and M+ is a monovalent metal ion, with a compound of formula (3) wherein R3 and R4 are as above, to form a compound of formula (4) and b) followed by contacting the compound of formula (4) with an acid to give a compound of formula (1), wherein step (a) and/or step (b) are conducted in continuous mode.Type: ApplicationFiled: February 12, 2018Publication date: January 2, 2020Applicant: PATHEON AUSTRIA GMBH & CO KGInventors: Paul Kohls, Peter Pöchlauer, Stefan Steinhofer, Christian Schuster
-
Patent number: 10364257Abstract: A process for a continuous production of a boronic acid derivative based on a Matteson boronic ester homologation and an apparatus of performing the process are disclosed.Type: GrantFiled: December 9, 2015Date of Patent: July 30, 2019Assignee: REMPEX PHARMACEUTICALS, INC.Inventors: Ulfried Felfer, Clemens Stueckler, Stefan Steinhofer, Andreas Pelz, Marcus Hanacek, Thomas Heinrich Pabst, George Winkler, Peter Poechlauer, Bas Ritzen, Michel Goldbach
-
Publication number: 20170369512Abstract: A process for a continuous production of a boronic acid derivative based on a Matteson boronic ester homologation and an apparatus of performing the process are disclosed.Type: ApplicationFiled: December 9, 2015Publication date: December 28, 2017Inventors: Ulfried Felfer, Clemens Stueckler, Stefan Steinhofer, Andreas Pelz, Marcus Hanacek, Thomas Heinrich Pabst, George Winkler, Peter Poechlauer, Bas Ritzen, Michel Goldbach
-
Patent number: 9550797Abstract: The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.Type: GrantFiled: June 27, 2014Date of Patent: January 24, 2017Assignee: Patheon Holdings I B.V.Inventors: Mehul Thathagar, Peter Poechlauer, Rafael Wilhelmus Elisabeth Ghislain Reintjens, Michel Goldbach
-
Publication number: 20160137669Abstract: The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.Type: ApplicationFiled: June 27, 2014Publication date: May 19, 2016Inventors: Mehul Thathagar, Peter Poechlauer, Rafael Wilhelmus Elisabeth Ghislain Reintjens, Michel Goldbach
-
Patent number: 9327263Abstract: The invention relates to a method for carrying out reactions with participation of carbocations, whereby the initial most strongly exothermic phase of the reaction is carried out at high temperature (60 to 120° C.) and short residence time (1 to 30 seconds) in a microreactor and the subsequent less exothermic phases are carried out at optionally lower temperatures in two or more residence time units with longer residence times (1 to 30 seconds).Type: GrantFiled: April 26, 2006Date of Patent: May 3, 2016Assignee: ESIM Chemicals GmbHInventors: Peter Pöchlauer, Martina Kotthaus, Martin Vorbach, Martin Deak, Thomas Zich, Rolf Marr
-
Patent number: 9249088Abstract: A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.Type: GrantFiled: November 1, 2011Date of Patent: February 2, 2016Assignee: DPx Holdings B.V.Inventors: Peter Poechlauer, Rafael Wilhelmus Elisabeth Ghislain Reintjens, Hubertus Johannes Adrianus Dielemans, Mehul Thathagar, Jeroen Hubertina Gerardus Konings
-
Publication number: 20140100360Abstract: A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.Type: ApplicationFiled: November 1, 2011Publication date: April 10, 2014Applicants: DSM FINE CHEMICALS AUSTRIA NFG. GMBH & CO KG, DSM IP ASSETS B.V.Inventors: Peter Poechlauer, Rafael Wilhelmus Elisabeth Ghislain Reintjens, Hubertus Johannes Adrianus Dielemans, Mehul Thathagar, Jeroen Hubertina Gerardus Konings
-
Patent number: 8536366Abstract: A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.Type: GrantFiled: December 19, 2008Date of Patent: September 17, 2013Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KGInventors: Sascha Braune, Stefan Steinhofer, Peter Poechlauer, Rafael Wilhelmus E. G. Reintjens, Nicole Theodora W. Linssen, Mehul Thathagar
-
Patent number: 8497384Abstract: A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula:CR1R2, in a reaction vessel, optionally in the presence of a solvent, wherein, R1 and R2 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R7 or —NR82; R3, R4, R5 and R6 are each independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R9, —NR102, —SR11, —S(O)R11, or —SO2R11, or R3 and R6 are as defined above and R4 and R5 together form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; R7 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy, heteroaryl or —NR102; R8 is hydrogen, C1-C6 alkyl, C1-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; R9 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy or heteroaryl; R10 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aType: GrantFiled: November 12, 2009Date of Patent: July 30, 2013Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KGInventors: Mehul Thathagar, Peter Poechlauer, Sascha Braune
-
Patent number: 8221708Abstract: A tube bundle falling film microreactor for performing gas-liquid reactions, which has: a) at least one vertical tube with b) a device for distributing the liquid on the inside of the tube and c) a liquid collecting system, and d) a device for gas supply and removal, and use thereof.Type: GrantFiled: May 29, 2008Date of Patent: July 17, 2012Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KGInventors: Florian Seebauer, Peter Poechlauer, Sascha Braune, Stefan Steinhofer
-
Patent number: 8106242Abstract: Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.Type: GrantFiled: May 23, 2007Date of Patent: January 31, 2012Assignee: DSM IP Assets B.V.Inventors: Rafael Wilhelmus Elisabeth Ghislain Reintjens, Quirinus Bernardus Broxterman, Martina Kotthaus, Peter Poechlauer
-
Publication number: 20110301359Abstract: A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula: CR1R2, in a reaction vessel, optionally in the presence of a solvent, wherein, R1 and R2 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R7 or —NR82; R3, R4, R5 and R6 are each independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, —C(O)R9, —NR102, —SR11, —S(O)R11, or —SO2R11, or R3 and R6 are as defined above and R4 and R5 together form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; R7 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy, heteroaryl or —NR102; R8 is hydrogen, C1-C6 alkyl, C1-C6 alkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; R9 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy or heteroaryl; R10 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl,Type: ApplicationFiled: November 12, 2009Publication date: December 8, 2011Inventors: Mehul Thathagar, Peter Poechlauer, Sascha Braune
-
Publication number: 20110034720Abstract: A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.Type: ApplicationFiled: December 19, 2008Publication date: February 10, 2011Inventors: Sascha Braune, Stefan Steinhofer, Peter Poechlauer, Rafael Wilhelmus E.G. Reintjens, Nicole Theodora W. Linssen, Mehul Thathagar
-
Publication number: 20100152479Abstract: A tube bundle falling film microreactor for performing gas-liquid reactions, which has: a) at least one vertical tube with b) a device for distributing the liquid on the inside of the tube and c) a liquid collecting system, and d) a device for gas supply and removal, and use thereof.Type: ApplicationFiled: May 28, 2008Publication date: June 17, 2010Inventors: Florian Seebauer, Peter Poechlauer, Sascha Braune, Stefan Steinhofer
-
Publication number: 20100029990Abstract: Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.Type: ApplicationFiled: May 23, 2007Publication date: February 4, 2010Inventors: Rafael Wilhelmus Elisabeth Ghislain Reintjens, Quirinus Bernardus Broxterman, Martina Kotthaus, Peter Poechlauer
-
Patent number: 7371866Abstract: A process for catalytically oxidizing alkylaromatic compounds of the formula (I) Ar—CH2—R where Ar is an optionally substituted, aromatic or heteroaromatic 5-membered or 6-membered ring or a ring system having up to 20 carbon atoms where Ar may optionally be fused to a C1-C6-alkyl group in which up to 2 carbon atoms may be replaced by a heteroatom, and R is hydrogen, phenyl, benzyl or heteroaryl, where the phenyl, benzyl or heteroaryl radicals may also be joined to Ar by a bridge, or R together with Ar forms an optionally substituted ring system which may contain one or more optionally substituted heteroatoms, to the corresponding aromatic or heteroaromatic carboxylic acids in a solvent with ozone in the presence of a transition metal catalyst and optionally in the presence of an acid at a temperature between ?70° C. and 110° C. to the corresponding carboxylic acid.Type: GrantFiled: May 15, 2003Date of Patent: May 13, 2008Assignee: DSM Fine Chemicals Austria Nfg GmbH & Co KGInventors: Walther Jary, Peter Poechlauer, Thorsten Ganglberger
-
Publication number: 20070196904Abstract: Disclosed is a method for producing chiral, secondary alcohols of formula (I), wherein A represents an aromatic, heterocyclic, or alicyclic ring or a ring system with 4 to 20 C atoms, n represents 0, 1, 2, 3, 4, or 5, R represents halogen, OH, an O— protective group, NO2, N,N—R2,R3 amine, R2 and R3 representing C1-C6 alkyl, phenyl, or benzyl, N,N—R2,R3-amino-C1-C6 alkyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C4 alkoxycarbonyl, or CN, and R1 represents N,N—R2,R3 amine, N,N—R2,R3-amino-C1-C6 alkyl, C1-C12 alkyl, C1-C6-haloalkyl, C1-C4 alkoxycarbonyl, C1-C6 alkoxy-C1-C6 alkyl, or a C2-C5 alkylene radical that forms a ring system along with the A radical.Type: ApplicationFiled: February 25, 2005Publication date: August 23, 2007Inventors: Thomas Dax, Michael Stanek, Peter Poechlauer