Patents by Inventor Peter Pack
Peter Pack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8513164Abstract: The present invention relates to a method of identifying one or more genes encoding one or more proteins having an optimized property. In particular, the method comprises expressing a collection of genes and screening for a desired property, identifying a plurality of genes having the desired property, and replacing one or more one or more sub-sequences of each of said genes with a different, compatible genetic sub-sequence, and screening again in order to identify genes encoding proteins having an optimized property.Type: GrantFiled: December 21, 2006Date of Patent: August 20, 2013Assignee: MorphoSys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun
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Publication number: 20080026948Abstract: The present invention relates to synthetic DNA sequence which encode one or more collections of homologous proteins(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: ApplicationFiled: December 21, 2006Publication date: January 31, 2008Applicant: MORPHOSYS AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Pluckthun
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Patent number: 7264963Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: GrantFiled: January 24, 2000Date of Patent: September 4, 2007Assignee: Morphosys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun
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Publication number: 20060003334Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: ApplicationFiled: April 29, 2004Publication date: January 5, 2006Applicant: Morphosys AGInventors: Knappik Achim, Peter Pack, Ge Liming, Moroney Simon, Pluckthun Andreas
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Patent number: 6828422Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: GrantFiled: January 24, 2000Date of Patent: December 7, 2004Assignee: Morphosys AGInventors: Knappik Achim, Peter Pack, Ge Liming, Moroney Simon, Plückthun Andreas
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Patent number: 6706484Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: GrantFiled: January 24, 2000Date of Patent: March 16, 2004Assignee: Morphosys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun
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Patent number: 6696248Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: GrantFiled: January 24, 2000Date of Patent: February 24, 2004Assignee: Morphosys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun
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Patent number: 6692935Abstract: The present invention relates to a method for targeted assembly of distinct active peptide or protein domains into a single complex and to such complexes. The invention relates particularly to the fusion of peptide or protein domains to complementary association domains which are derived from a single tertiary or quaternary structure by segmentation. The association domains are designed to assemble in a complementary fashion, thereby providing multifunctional (poly)peptides.Type: GrantFiled: May 30, 2000Date of Patent: February 17, 2004Assignee: MorphoSys AGInventors: Peter Pack, Andrei Lupas
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Patent number: 6300064Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: GrantFiled: February 18, 1998Date of Patent: October 9, 2001Assignee: Morphosys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun
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Patent number: 6294353Abstract: The present invention relates to a method for targeted assembly of distinct active peptide or protein domains into a single complex and to such complexes. The invention relates particularly to the fusion of peptide or protein domains to complementary association domains which are derived from a single tertiary or quaternary structure by segmentation. The association domains are designed to assemble in a complementary fashion, thereby providing multifunctional (poly)peptides.Type: GrantFiled: September 23, 1997Date of Patent: September 25, 2001Assignee: MorphoSys AGInventors: Peter Pack, Andrei Lupas
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Patent number: 5910573Abstract: The present invention describes a new class of antigen binding molecules which contain Fv-fragments of an antibody but do not use the constant antibody domains. They can also dimerize with other antibody fragment molecules or with non-antibody fragment molecules to form bi- or multifunctional antibody-fragment fusion proteins and so-called miniantibodies, respectively. The new fusion proteins can be used in the broad field of diagnostic and therapeutical medicine.Type: GrantFiled: July 22, 1994Date of Patent: June 8, 1999Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Andreas Pluckthun, Peter Pack