Abstract: The invention relates to a method of detecting the coincidence of two biomolecular structures in a solid phase sample, said method comprising: (i) providing a first and a second fusion protein, each fusion protein comprising (a) a detection domain, said detection domain comprising a DNA binding domain; said detection domain capable of binding a cognate specific nucleotide sequence in co-operation with a further detection domain; (b) a recognition domain, said recognition domain capable of binding a target biomolecular structure; and (c) a connector domain; said connector domain being fused at one end to the detection domain and being fused at the other end to the recognition domain; wherein at least two of (a), (b) and (c) are heterologous to one another; wherein the recognition domains of said first and said second fusion proteins are capable of binding to first and second biomolecular structures; (ii) contacting the sample with said first and second fusion proteins; (iii) incubating to allow binding; (iv) r

Abstract: Techniques for synchronizing a receiver and transmitter in a wireless communication system address synchronization within the context of a detection formulation and provide synchronization statistics used to declare a synchronization detection. A signal is received from a channel at multiple receiving antennas. The receiver and transmitter are synchronized based on the received signal and a channel model incorporating the multiple receiving antennas. The channel model may also incorporate a resolvable delay spread of the received signal with respect to each receiving antenna. Synchronization may be based on a known component of a received signal and further on a channel model incorporating multiple receiving antennas and an interference signal. The known component may be a cyclic prefix or a pilot sequence as in orthogonal frequency division multiplexing (OFDM).

Abstract: Techniques for synchronizing a receiver and transmitter in a wireless communication system address synchronization within the context of a detection formulation and provide synchronization statistics used to declare a synchronization detection. A signal is received from a channel at multiple receiving antennas. The receiver and transmitter are synchronized based on the received signal and a channel model incorporating the multiple receiving antennas. The channel model may also incorporate a resolvable delay spread of the received signal with respect to each receiving antenna. Synchronization may be based on a known component of a received signal and further on a channel model incorporating multiple receiving antennas and an interference signal. The known component may be a cyclic prefix or a pilot sequence as in orthogonal frequency division multiplexing (OFDM).

Abstract: A method and apparatus are provided for operation of an image sensor during signal readout. During a reset operation the gate of a reset transistor coupled to the storage node receives a voltage greater than a threshold voltage to produce a reset of the storage node. During a period where photogenerated charges stored at the storage node are read out the gate of the reset transistor receives a voltage VRST—LOW greater than ground, but less than a maximum voltage which can be stored at the storage node.

Abstract: A positioning and calibration system are provided for use in calibrating a single or multi axis sensitive instrument, such as an inclinometer. The positioning system includes a positioner that defines six planes of tangential contact. A mounting region within the six planes is adapted to have an inclinometer coupled thereto. The positioning system also includes means for defining first and second flat surfaces that are approximately perpendicular to one another with the first surface adapted to be oriented relative to a local or induced reference field of interest to the instrument being calibrated, such as a gravitational vector. The positioner is positioned such that one of its six planes tangentially rests on the first flat surface and another of its six planes tangentially contacts the second flat surface. A calibration system is formed when the positioning system is used with a data collector and processor.

Abstract: A method of operating an imager pixel that includes the act of applying a relatively small voltage on the gate of a transfer transistor during a charge acquisition period. If a small positive voltage is applied, a depletion region is created under the transfer transistor gate, which creates a path for dark current electrons to be transferred to a pixel floating diffusion region. The dark electrons are subsequently removed by a pixel reset operation. If a small negative voltage is applied to the transfer gate, electrons that would normally create dark current problems will instead recombine with holes thereby substantially reducing dark current.

Abstract: A positioning and calibration system are provided for use in calibrating a single or multi axis sensitive instrument, such as an inclinometer. The positioning system includes a positioner that defines six planes of tangential contact. A mounting region within the six planes is adapted to have an inclinometer coupled thereto. The positioning system also includes means for defining first and second flat surfaces that are approximately perpendicular to one another with the first surface adapted to be oriented relative to a local or induced reference field of interest to the instrument being calibrated, such as a gravitational vector. The positioner is positioned such that one of its six planes tangentially rests on the first flat surface and another of its six planes tangentially contacts the second flat surface. A calibration system is formed when the positioning system is used with a data collector and processor.

Abstract: A method of operating an imager pixel that includes the act of applying a relatively small voltage on the gate of a transfer transistor during a charge acquisition period. If a small positive voltage is applied, a depletion region is created under the transfer transistor gate, which creates a path for dark current electrons to be transferred to a pixel floating diffusion region. The dark electrons are subsequently removed by a pixel reset operation. If a small negative voltage is applied to the transfer gate, electrons that would normally create dark current problems will instead recombine with holes thereby substantially reducing dark current.

Abstract: A method and apparatus are provided for operation of an image sensor during signal readout. During a reset operation the gate of a reset transistor coupled to the storage node receives a voltage greater than a threshold voltage to produce a reset of the storage node. During a period where photogenerated charges stored at the storage node are read out the gate of the reset transistor receives a voltage VRST—LOW greater than ground, but less than a maximum voltage which can be stored at the storage node.

Abstract: A method of providing a customer with postage stamps including images provided by the customer includes (a) receiving image data from a customer, (2) combining the image data with postal indicia to produce an electronic image of a postage stamp, (3) providing an image of a postage stamp including the image data received from the customer for customer review, (4) reviewing the image data for compliance with predetermined criteria, (5) printing the postage stamp, and (6) forwarding the printed stamps to the customer.

Abstract: A single vector calibration system is provided which facilitates the calibration of multi-axis load cells, including wind tunnel force balances. The single vector system provides the capability to calibrate a multi-axis load cell using a single directional load, for example loading solely in the gravitational direction. The system manipulates the load cell in three-dimensional space, while keeping the uni-directional calibration load aligned. The use of a single vector calibration load reduces the set-up time for the multi-axis load combinations needed to generate a complete calibration mathematical model. The system also reduces load application inaccuracies caused by the conventional requirement to generate multiple force vectors. The simplicity of the system reduces calibration time and cost, while simultaneously increasing calibration accuracy.

Abstract: A single vector calibration system is provided which facilitates the calibration of multi-axis load cells, including wind tunnel force balances. The single vector system provides the capability to calibrate a multi-axis load cell using a single directional load, for example loading solely in the gravitational direction. The system manipulates the load cell in three-dimensional space, while keeping the uni-directional calibration load aligned. The use of a single vector calibration load reduces the set-up time for the multi-axis load combinations needed to generate a complete calibration mathematical model. The system also reduces load application inaccuracies caused by the conventional requirement to generate multiple force vectors. The simplicity of the system reduces calibration time and cost, while simultaneously increasing calibration accuracy.

Abstract: A process for producing a creped sheet as well as a creping blade and creped paper product formed by such blade is set forth with the process including the steps of adhering a cellulosic web to a moving surface, providing a stepped creping blade disposed to crepe the cellulosic web from the moving surface and creping the cellulosic web from the moving surface forms a creped paper product having greater bulk and absorbency than previously prepared creped paper products.

Abstract: A process for producing a creped sheet as well as a creping blade and creped paper product formed by such blade is set forth with the process including the steps of adhering a cellulosic web to a moving surface, providing a stepped creping blade disposed to crepe the cellulosic web from the moving surface and creping the cellulosic web from the moving surface forms a creped paper product having greater bulk and absorbency than previously prepared creped paper products.

Abstract: A signal translator that translates a device detectable signal into an electrical signal directed to an output that an operator with impaired hearing can perceive. Preferably, a detected signal is translated into a generated electrical signal directed to a loudspeaker. The loudspeaker then sounds a tone of a volume and a frequency selectable by an operator. Alternatively, the device detectable signal is a detected audio signal. The detected signal can also be a turn signal flasher of a vehicle. The detected signal is translated to a generated electrical signal transmitted to a loudspeaker. A strobe light from an emergency vehicle can also perform as the detected signal, when the invention includes an emergency vehicle signal decoder for discerning the strobe light from an emergency vehicle. The signal translator includes a trigger for translating a detected signal into a generated signal for transmission to an operator perceivable signal.

Abstract: Nucleoside thiotriphosphates carrying .sup.32 P in the gamma-thiophosphate group, prepared by reaction between a nucleoside diphosphate and .sup.32 p labelled thiophosphate salt, are used as thiophosphorylating agents for antibodies that bind to tumour-associated antigens. The labelled thiotriphosphates can be used to introduce a therapeutically useful .sup.32 P atom into an antibody that has been modified by the incorporation into its structute of a peptide region capable of acting as a substrate for a phosphokinase. The resulting labelled antibody can then be used for injection in anti-tumour therapy and has clinical advantages over the corresponding phosphoylated analogue.

Abstract: Nucleoside thiotriphosphates carrying .sup.32 P in the gamma-thiophosphate group, prepared by reaction between a nucleoside diphosphate and a .sup.32 P labelled thiophosphate salt, are used as thiophosphorylating agents for antibodies that bind to tumour-associated antigens. The labelled thiotriphosphates can be used to introduce a therapeutically useful .sup.32 P atom into an antibody that has been modified by the incorporation into its structure of a peptide region capable of acting as a substrate for a phosphokinase. The resulting labelled antibody can then be used for injection in anti-tumour therapy and has clinical advantages over the corresponding phosphorylated analogue.

Abstract: A method is provided for attaching .sup.32 P to a protein, normally an antibody, that will bind with and irradiate a tumor-associated structure leading to diagnostic benefit. The invention is based upon the introduction of a peptide region to the protein, which is capable of acting as a substrate for a phosphokinase utilizing .sup.32 P-.gamma.-ATP as a typical source of the radionuclide. The conjugation of the substrate molecule to the protein may be achieved by chemical methods or by genetic engineering techniques. Novel substrate peptides are disclosed.