Abstract: A tamper-indicating closure combination consisting of a container having a circular neck and a twist-on cap therefor. The container neck has external interrupted thread sections with ratchet teeth on their under surfaces. The cap has similar, cooperating internal thread sections on the inner surface of its skirt with ratchet teeth on their upper surfaces. When the cap is turned onto the neck, the sets of ratchet teeth interengage and lock the cap against retrograde rotation. The cap also has a puller which is connected to the cap, a first section thereof being connected by frangible portions and a second section thereof being connected permanently to said cap. In order to remove the cap, the puller is broken away at the first section and then is pulled upwardly and outwardly relative to the container neck to disengage the cooperating sets of ratchet teeth. The cap is replaced by turning it onto the bottle neck for re-engaging the cooperating threads and ratchet teeth.