Patents by Inventor Peter S. Conti
Peter S. Conti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230416293Abstract: Thymidine analogues, 5-substituted 2?-deoxy-2?-[18F]fluoro-arabinofuranosyluracil derivatives, are promising positron emission tomography (PET) tracers being evaluated for noninvasively imaging cancer cell proliferation and/or reporter gene expression. We report the radiosynthesis of 2?-deoxy-2?-[18F]fluoro-5-methyl-1-?-d-arabinofuranosyluracil ([18F]FMAU) and other 2?-deoxy-2?-[18F]fluoro-5-substituted-1-?-d-arabinofuranosyluracil analogues using 1,4-dioxane to replace the currently used 1,2-dichloroethane. Compared to 1,2-dichloroethane, 1,4-dioxane is analyzed as a better solvent in terms of radiosynthetic yield and toxicity concern. The use of a less toxic solvent allows for the translation of the improved approach to clinical production. The new radiolabeling method can be applied to an extensive range of uses for 18F-labeling of other nucleoside analogues.Type: ApplicationFiled: November 19, 2021Publication date: December 28, 2023Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Kai CHEN, Peter S. CONTI
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Publication number: 20210347709Abstract: The invention provides a radiopharmaceutical compound or composition comprising a radiolabeled linear peptide that binds specifically to Glypican-3 (GPC3) expressed on a surface of a cell. Preferably, the linear peptide is conjugated to one or more 18F atoms.Type: ApplicationFiled: April 30, 2021Publication date: November 11, 2021Applicant: University of Southern CaliforniaInventors: Kai Chen, Peter S. CONTI
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Patent number: 11065349Abstract: This invention provides a class of dual mode imaging tracer capable of acting both as a fluorescent imaging tracer and a positron emission tomography imaging tracer. Tracers in accordance with this invention generally have a fluorescent core with a boron-fluoride element embedded therein. Exemplary embodiments of the tracer include 18F-labeled BODIPY compounds and derivative thereof. Also provided are tracer kits containing a sterile formulation of a BODIPY dye either in a radio-labeled or pre-labeled state, and methods for imaging heart perfusion using the 18F-labeled dual mode tracers.Type: GrantFiled: March 15, 2013Date of Patent: July 20, 2021Inventors: Peter S. Conti, Zibo Li, Shuanglong Liu, Dan Li
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Publication number: 20210009624Abstract: Provided herein are methods and labeling kits for synthesizing 2?-deoxy-2?-[18F]fluoro-5-methyl-1-beta-D-arabino-furanosyl-uracil in a one-pot reaction in compliance with CGMP. Also disclosed are labeling kits that can be assembled in an automated synthesis system to enable such a reaction.Type: ApplicationFiled: March 29, 2019Publication date: January 14, 2021Inventors: Kai Chen, Peter S. Conti
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Patent number: 10646598Abstract: Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.Type: GrantFiled: June 27, 2016Date of Patent: May 12, 2020Assignee: University of Southern CaliforniaInventors: Peter S. Conti, Hancheng Cai, Zibo Li, Shuanglong Liu
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Patent number: 10471161Abstract: A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group.Type: GrantFiled: March 8, 2014Date of Patent: November 12, 2019Assignees: University of Southern California, City of HopeInventors: Zibo Li, Peter S. Conti, Lin Li, Zhanhong Wu, Shuanlong Liu, John E. Shively, David Horne
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Patent number: 10434197Abstract: A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.Type: GrantFiled: July 21, 2011Date of Patent: October 8, 2019Assignees: University of Delaware, University of Southern CaliforniaInventors: Joseph M. Fox, Matthew Hassink, Melissa Blackman, Zibo Li, Peter S. Conti, Ramajeyam Selvaraj
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Patent number: 9987380Abstract: A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.Type: GrantFiled: July 13, 2012Date of Patent: June 5, 2018Assignee: University of Southern CaliforniaInventors: Zibo Li, Francois P. Gabbai, Peter S. Conti, Todd W. Hudnall, Tzu-Pin Lin, Shuanglong Liu, Chiun-Wei Huang
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Patent number: 9789211Abstract: This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled with 64Cu or 18F. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.Type: GrantFiled: March 15, 2013Date of Patent: October 17, 2017Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Peter S. Conti, Shuanglong Liu, Zibo Li
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Publication number: 20170189567Abstract: Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.Type: ApplicationFiled: June 27, 2016Publication date: July 6, 2017Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Peter S. Conti, Hancheng Cai, Zibo Li, Shuanglong Liu
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Patent number: 9403875Abstract: Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.Type: GrantFiled: January 27, 2010Date of Patent: August 2, 2016Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Peter S. Conti, Hancheng Cai, Zibo Li, Shuanglong Liu
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Publication number: 20160015838Abstract: A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group.Type: ApplicationFiled: March 8, 2014Publication date: January 21, 2016Applicant: University of Southern California USC StevensInventors: Zibo LI, Peter S. CONTI, Lin LI, Zhanhong WU, Shuanlong LIU, John E. SHIVELY, David HORNE
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Publication number: 20150297760Abstract: This invention provides a class of dual mode imaging tracer capable of acting both as a fluorescent imaging tracer and a positron emission tomography imaging tracer. Tracers in accordance with this invention generally have a fluorescent core with a boron-fluoride element embedded therein. Exemplary embodiments of the tracer include 18F-labeled BODIPY compounds and derivative thereof. Also provided are tracer kits containing a sterile formulation of a BODIPY dye either in a radio-labeled or pre-labeled state, and methods for imaging heart perfusion using the 18F-labeled dual mode tracers.Type: ApplicationFiled: March 15, 2013Publication date: October 22, 2015Applicant: University of Southern CaliforniaInventors: Peter S. CONTI, Zibo LI, Shuanglong LIU, Dan LI
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Publication number: 20150132222Abstract: This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled with 64Cu or 18F. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.Type: ApplicationFiled: March 15, 2013Publication date: May 14, 2015Applicant: University of Southern CaliforniaInventors: Peter S. Conti, Shuanglong Liu, Zibo Li
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Patent number: 8912319Abstract: The present invention relates to methods of synthesizing 18F-FMAU. In particular, 18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substituted thymidine or cytidine analogs. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogs) can be used as probes for imaging tumor proliferative activity. More specifically, these [18F]-labeled thymidine or cytidine analogs can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.Type: GrantFiled: July 15, 2011Date of Patent: December 16, 2014Assignee: University of Southern CaliforniaInventors: Zibo Li, Hancheng Cai, Peter S. Conti
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Publication number: 20130266512Abstract: A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.Type: ApplicationFiled: July 21, 2011Publication date: October 10, 2013Applicants: University of Southern California, University of DelawareInventors: Joseph M. Fox, Matthew Hassink, Melissa Blackman, Zibo Li, Peter S. Conti, Ramajeyam Selvaraj
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Patent number: 8506926Abstract: 2?-Deoxy-2?-[18F]-labeled and 3?-deoxy-3?-[18F]-labeled purine nucleoside analogs such as [18F]-FAA and [18F]-FXA have been found to have desirable properties for use as imaging agents. The analogs are particularly useful for in vivo imaging of biological material including organ tissues (e.g., heart, liver, brain and kidneys) and tumors. Methods for the preparation of the [18F]-FAA and [18F]-FXA are also provided.Type: GrantFiled: August 8, 2007Date of Patent: August 13, 2013Assignee: University of Southern CaliforniaInventors: Peter S. Conti, Mian M. Alauddin, John D. Fissekis
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Publication number: 20130189185Abstract: A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.Type: ApplicationFiled: July 13, 2012Publication date: July 25, 2013Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Zibo LI, Francois P. GABBAI, Peter S. CONTI, Todd W. HUDNALL, Tzu-Pin LIN, Shuanglong LIU, Chiun-Wei HUANG
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Publication number: 20120053337Abstract: The present invention relates to methods of synthesizing 18F-FMAU. In particular, 18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substitued thymidine or cytidine analogues. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogues) can be used as probes for imaging tumor proliferative activity. More specifically, these [18F]-labeled thymidine or cytidine analogues can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.Type: ApplicationFiled: July 15, 2011Publication date: March 1, 2012Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Zibo Li, Hancheng Cai, Peter S. Conti
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Publication number: 20100196271Abstract: Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.Type: ApplicationFiled: January 27, 2010Publication date: August 5, 2010Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Peter S. Conti, Hancheng Cai, Zibo Li