Abstract: A delivery portal, which may be at a loading dock, includes a sensor configured to detect a pallet, platform or stack of goods as it passes through the portal. A computer is programmed to receive information from the sensor and to identify the pallet based upon the information. The computer is further programmed to compare the identified pallet to a database to determine if the identified pallet should be passing through the portal. For example, the computer determines whether the pallet is being loaded onto the wrong truck or onto the right truck but in the wrong sequence. The sensor for detecting the pallet may be an RFID sensor reading an RFID tag on the pallets. The portal may be a loading dock. The database may indicate a sequence for loading a plurality of pallets including the identified pallet onto a truck at the loading dock.

Abstract: A drug delivery system includes a container comprising a luer compartment and a fluid compartment, a luer fitting arranged within the luer compartment and in fluidic communication with the fluid compartment, and a dispenser in fluidic communication with the fluid compartment. A method of aseptically transferring a drug to such a drug delivery system may include providing a vial comprising the drug to be transferred, withdrawing a volume of the drug from the vial with a syringe, coupling the syringe to a drug delivery system via the luer fitting, transferring the drug from the syringe to the drug delivery system, and decoupling the syringe from the drug delivery system.

Abstract: A technique for microsegmentation includes receiving information related to hosts and applications operating in a network where the information was obtained based on a survey of the network; identifying a plurality of microsegments utilizing the information, each microsegment includes a set of hosts similar to one another; for each of the plurality of microsegments, identifying security policies that control access to hosts in each microsegment; and providing the plurality of microsegments and corresponding security policies for approval thereof.

Abstract: Systems and methods include receiving network communication information about hosts in a network and applications executed on the hosts; automatically generating one or more microsegments in the network based on analysis of the obtained network communication information, wherein each microsegment of the one or more microsegments is a grouping of resources including the hosts and the applications executed on the hosts that have rules for network communication; and providing the one or more microsegments to one or more hosts of the hosts, for use by the one or more hosts to allow or block communications locally based on the one or more microsegments. Each of the one or more microsegments can be a grouping of workloads inside a data center.

Abstract: A school bus stop arm and drive unit therefor are disclosed. The stop arm includes a stop sign and a drive unit for moving the stop sign between a retracted position and a deployed position. In some embodiments the stop sign is illuminated. In some embodiments the drive unit includes a controller.

Abstract: Described herein are oligonucleotides (e.g., single-stranded oligonucleotides) and compositions thereof for targeting a mutation in the spliceosome, such as the U 1 small nuclear RNA (snRNA), as well as related methods of use.

Abstract: Disclosed herein are methods and compositions for a new way to separate biologics using coated pegboards—plastic plates affixed with an array of 96-pegs which align with the wells of a traditional 96-well plate used in bench top experiments. The ends of the pegs are conjugated to various compounds which are able to bind tags on engineered proteins (ex. Ni-NTA would bind a His-Tag on an engineered protein). These pegs extend into plate wells to specifically bind the tagged protein from the cell lysate which contains hundreds of other proteins. The pegboard, now laden with the protein of interest (POI), may then be dipped into sequential buffers to wash away potential non-specifically bound proteins to purify the POI.

Abstract: The present disclosure features compounds of formula (1-a) and of formula (II) and pharmaceutical compositions thereof. The present disclosure further discloses the compounds of formula (I-a) and (II) and their compositions for use in methods of modulating nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as said compounds for use in methods of treating e.g.: ?proliferative diseases, such as e.g. cancer, benign neoplasms or angiogenesis, ?neurological diseases or disorders, such as e.g. Huntington's disease, ?autoimmune diseases or disorders, immunodeficiency diseases or disorders, lysosomal storage disease or disorder, cardiovascular diseases or disorders, metabolic diseases or disorders, respiratory diseases or disorders, renal diseases or disorders, or infectious diseases. Exemplary compounds are e.g. 2-(indazol-5-yl)-6-(piperidin-4-yl)-1,7-naphthyridine derivatives and similar compounds.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: The present invention provides a composition comprising the compound having the structure: or a salt of the compound; 4-amino-2-[19F]-fluorobenzoic acid or a salt of 4-amino-2-[19F]-fluorobenzoic acid; and at least one acceptable carrier.

Abstract: A system validates the establishment and/or continuation of a connection between two applications over a network. The system uses network application security rules to allow or disallow connections between the two applications. Those rules include definitions of the source and destination applications to which the rules apply. The system automatically updates the application definitions over time to encompass new versions of the applications covered by the security rules, but without encompassing other applications. The system is then capable of applying the updated rules both to the original applications and to the updated versions of those applications. This process enables the security rules to maintain security over time in a way that is consistent with the original intent of the rules even as applications on the network evolve.

Abstract: Aspects of the invention include setting a fill mode for a border region of a layer of a macro of an integrated circuit. The border region has a depth defined by a multiple of the size of a tile used to select an area of the integrated circuit for implementation of a design rule check, and the fill mode indicates a fill percentage value or level of fill to be implemented in the border region of the layer of the macro. A fill of the border region of the layer of the macro is performed based on the fill mode. The integrated circuit is finalized and fabricated based on the performing of the fill and passing the design rule check.

Abstract: The present invention concerns the verification and authentication of independent digital wallets and, particularly, the linking of regulated and unregulated digital wallets on a public blockchain. An unregulated trading system has a public certificate module arranged selectively to write NFTs into specific unregulated accounts. A public ledger database of the blockchain system stores unregulated accounts which each contain: (i) a document type identifier having a related minted unique non-transferable NFT linked to an externally generated certificate hash and where each non-transferable NFT is obtained via writing of a smart contract and each non-transferable NFT is a permanent record for a description of the document type; and (ii) a link to a private wallet of a regulated account of a regulated trading platform. The link relates directly to the minted non-transferable NFT issued from the certificate module.

Abstract: Disclosed is a method and system, in FIG. 1, for verifying authenticity of specific personal data responsive to a unique wallet address (70) on a public ledger (66) of an unregulated platform (60). The wallet contains one or more non-transferable NFTs each locked to the wallet and related to specific personal data. The non-transferable NFT was minted from a regulated platform (27) to which there is a record (76) in the public ledger. Supplying the unique address of the wallet to a service supplier affects a log-in of a client (18) to the service supplier (90), whereafter message interactions over a network (12) between the service supplier and the unregulated platform (60) permits searching for a relevant (72) non-transferable NFTs (74) stored in the wallet and related to the specific personal data. Return of any relevant non-transferable NFT related to the personal data thus verifies authenticity of the specific personal data by association with a regulated platform.

Abstract: Disclosed is a method and system, in FIG. 1, for verifying authenticity of specific personal data responsive to a unique wallet address (70) on a public ledger (66) of an unregulated platform (60). The wallet contains one or more non-transferable NFTs each locked to the wallet and related to specific personal data. The non-transferable NFT was minted from a regulated platform (27) to which there is a record (76) in the public ledger. Supplying the unique address of the wallet to a service supplier affects a log-in of a client (18) to the service supplier (90), whereafter message interactions over a network (12) between the service supplier and the unregulated platform (60) permits searching for a relevant (72) non-transferable NFTs (74) stored in the wallet and related to the specific personal data. Return of any relevant non-transferable NFT related to the personal data thus verifies authenticity of the specific personal data by association with a regulated platform.

Abstract: A method and an intersection testing module in a ray tracing system for determining whether a ray intersects a three-dimensional axis-aligned box. It is determined whether a first condition is satisfied, wherein the first condition is, or is equivalent to, ? "\[LeftBracketingBar]" C x - C z ? D x D z ? "\[RightBracketingBar]" ? H z ? D x D z + H x . It is determined whether a second condition is satisfied, wherein the second condition is, or is equivalent to, ? "\[LeftBracketingBar]" C y - C z ? D y D z ? "\[RightBracketingBar]" ? H z ? D y D z + H y .

Abstract: Provided herein is a combination therapy useful for the treatment hepatocellular carcinoma. The combination comprises an FGFR4 inhibitor and lenvatinib.

Abstract: Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.

Abstract: A school bus stop arm and drive unit therefor are disclosed. The stop arm includes a stop sign and a drive unit for moving the stop sign between a retracted position and a deployed position. In some embodiments the stop sign is illuminated. In some embodiments the drive unit includes a controller.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.