Abstract: Devices and methods are provided for acquiring and analyzing an image data file to generate diagnostic information reflecting an individual lung compartment. A lung compartment could be an entire lobe, a segment or a subsegment and beyond, hereinafter subsegments and beyond will be referred to simply as segments. Such analysis is used to assess the level of disease of individual lung compartments, both for quantification of the disease state and for determining the most appropriate treatment plan. This analysis allows the imaging technology to be used as a functional diagnostic tool as well as an anatomical diagnostic tool. To this end, dynamic data or images may also be acquired at specific points throughout the breathing cycle. Since air movement in and out of a lung compartment during the breathing cycle is a direct indicator of lung function in some diseases like emphysema, analysis of images during the breathing cycle will indicate levels of disease.

Abstract: The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance.

Abstract: An intravascular catheter comprises a proximal portion and a distal portion. The proximal portion has greater torsional stiffness than the distal portion, while the distal portion has greater dependability than the proximal portion. In accordance with this invention the distal portion carries a helical wire support member embedded therein, the helical support member being essentially free of crossing wires, to provide kink-resistance upon bending to the distal portion.