Patents by Inventor Peter Stegmeier
Peter Stegmeier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240052354Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.Type: ApplicationFiled: October 19, 2022Publication date: February 15, 2024Inventors: Eric BILLY, Antoine DE WECK, Javad GOLJI, Gregory HOFFMAN, Francesco HOFMANN, Audrey KAUFFMANN, Konstantinos John MAVRAKIS, Earl Robert MCDONALD, III, William SELLERS, Tobias SCHMELZLE, Frank Peter STEGMEIER, Michael Ray SCHLABACH, JR.
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Patent number: 11530413Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.Type: GrantFiled: July 20, 2018Date of Patent: December 20, 2022Assignee: Novartis AGInventors: Eric Billy, Antoine De Weck, Javad Golji, Gregory Hoffman, Francesco Hofmann, Audrey Kauffmann, Konstantinos John Mavrakis, Earl Robert McDonald, III, William Sellers, Tobias Schmelzle, Frank Peter Stegmeier, Michael Ray Schlabach, Jr.
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Publication number: 20210155932Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.Type: ApplicationFiled: July 20, 2018Publication date: May 27, 2021Inventors: Eric BILLY, Antoine DEWECK, Javad GOLJI, Gregory HOFFMAN, Francesco HOFMANN, Audrey KAUFFMANN, Konstantinos John MAVRAKIS, Earl Robert MCDONALD, III, William SELLERS, Tobias SCHMELZLE, Frank Peter STEGMEIER, Michael Ray SCHLABACH, Jr.
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Publication number: 20180282728Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-Catenin-related diseases such as adenomatous polyposis of the colon, colorectal cancer, basal cell carcinoma, breast cancer, kidney cancer, Wilms tumors, medulloblastoma, ovarian cancer, adrenocortical tumors, gastric cancer, liver cancer, melanoma, pancreatic cancers, prostate cancer, renal cancer, ectopic teeth and taste papillae, skin cancer, pilomatrixoma, anaplastic thyroid carcinoma, and uterine carcinosarcoma, oligodontia, osteoporosis, ageing, degenerative diseases, bedsores, chronic wounds and impaired wound healing, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to Beta-Catenin.Type: ApplicationFiled: June 13, 2018Publication date: October 4, 2018Inventors: Brian Richard Bettencourt, David Anton Bumcrot, Dieter Huesken, Satyanarayana Kuchimanchi, Stuart Milstein, Michael Ray Schlabach, JR., Frank Peter Stegmeier, Markus Warmuth, Jan Weiler
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Publication number: 20180258491Abstract: The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate FIRM inhibitors, and associated methods of treatment are also provided.Type: ApplicationFiled: December 22, 2017Publication date: September 13, 2018Applicant: Novartis AGInventors: Zainab JAGANI, Gregory HOFFMAN, Frank Peter STEGMEIER, Craig Stephen MICKANIN
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Patent number: 10023862Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-Catenin-related diseases such as adenomatous polyposis of the colon, colorectal cancer, basal cell carcinoma, breast cancer, kidney cancer, Wilms tumors, medulloblastoma, ovarian cancer, adrenocortical tumors, gastric cancer, liver cancer, melanoma, pancreatic cancers, prostate cancer, renal cancer, ectopic teeth and taste papillae, skin cancer, pilomatrixoma, anaplastic thyroid carcinoma, and uterine carcinosarcoma, oligodontia, osteoporosis, ageing, degenerative diseases, bedsores, chronic wounds and impaired wound healing, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to Beta-Catenin.Type: GrantFiled: January 8, 2013Date of Patent: July 17, 2018Assignee: Arrowhead Pharmaceuticals, Inc.Inventors: Brian Richard Bettencourt, David Anton Bumcrot, Dieter Huesken, Satyanarayana Kuchimanchi, Stuart Milstein, Michael Ray Schlabach, Jr., Frank Peter Stegmeier, Markus Warmuth, Jan Weiler
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Publication number: 20180010132Abstract: The invention provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is MTAP-deficient and/or MTA-accumulating and thus amenable to therapeutic treatment with a PRMT5 inhibitor. Kits, methods of screening for candidate PRMT5 inhibitors, and associated methods of treatment are also provided.Type: ApplicationFiled: September 9, 2015Publication date: January 11, 2018Applicant: Novartis AGInventors: Konstantinos John MAVRAKIS, Earl Robert MCDONALD, III, Frank Peter STEGMEIER
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Patent number: 9850543Abstract: The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided.Type: GrantFiled: March 12, 2014Date of Patent: December 26, 2017Assignee: Novartis AGInventors: Zainab Jagani, Gregory Hoffman, Frank Peter Stegmeier, Craig Stephen Mickanin
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Publication number: 20160091485Abstract: The invention provides methods of detecting an EZH2 mutation and associated epigenetic markers in a cancer cell, methods cancer diagnosis and methods of screening for EZH2 inhibitors.Type: ApplicationFiled: April 11, 2014Publication date: March 31, 2016Applicants: THE BROAD INSTITUTE, INC., NOVARTIS AGInventors: Ho Man CHAN, Veronica GIBAJA, Kristy HAAS, Jacob JAFFE, Mariela JASKELIOFF, Frank Peter STEGMEIER, Wei QI
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Publication number: 20160032402Abstract: The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided.Type: ApplicationFiled: March 12, 2014Publication date: February 4, 2016Applicant: Novartis AGInventors: Zainab JAGANI, Gregory HOFFMAN, Frank Peter STEGMEIER, Craig Stephen MICKANIN
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Publication number: 20150354006Abstract: The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors.Type: ApplicationFiled: October 15, 2013Publication date: December 10, 2015Applicants: Novartis AG, Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.Inventors: Ho Man CHAN, Nathan P. ENGLUND, Levi GARRAWAY, Min HU, Jacob JAFFE, Gregory KRYUKOV, Jun LIU, Xianghui LIU, Rob MCDONALD, Frank Peter STEGMEIER, Zhaofu WANG, Yan WANG, Haiping WU, Feng YAN
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Publication number: 20150291954Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-Catenin-related diseases such as adenomatous polyposis of the colon, colorectal cancer, basal cell carcinoma, breast cancer, kidney cancer, Wilms tumors, medulloblastoma, ovarian cancer, adrenocortical tumors, gastric cancer, liver cancer, melanoma, pancreatic cancers, prostate cancer, renal cancer, ectopic teeth and taste papillae, skin cancer, pilomatrixoma, anaplastic thyroid carcinoma, and uterine carcinosarcoma, oligodontia, osteoporosis, ageing, degenerative diseases, bedsores, chronic wounds and impaired wound healing, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to Beta-Catenin.Type: ApplicationFiled: January 8, 2013Publication date: October 15, 2015Applicant: NOVARTIS AGInventors: Brian Richard Bettencourt, David Anton Bumcrot, Dieter Huesken, Satyanarayana Kuchimanchi, Stuart Milstein, Michael Ray Schlabach, JR., Frank Peter Stegmeier, Markus Warmuth, Jan Weiler
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Patent number: 7997309Abstract: A system for measuring the length of a tree being processed through a delimber including a log feed roller mechanism for moving the tree, a delimbing head for delimbing the tree that is movable in a forward and reverse direction relative to the log feed roller mechanism, a measuring wheel resiliently mounted on the delimbing head, and a trimsaw movably mounted on the delimbing head. The length of the processed tree extending beyond the delimbing head may be calculated from signals encoded by the log feed roller mechanism and the measuring wheel. Logs may be cut from the tree by the trimsaw. Two photosensors located at known positions may be used to calculate the total length of the tree.Type: GrantFiled: November 30, 2006Date of Patent: August 16, 2011Assignee: Risley Enterprises Ltd.Inventors: Reggald Emory Isley, Peter Stegmeier
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Publication number: 20080128051Abstract: A system for measuring the length of a tree being processed through a delimber including a log feed roller mechanism for moving the tree, a delimbing head for delimbing the tree that is movable in a forward and reverse direction relative to the log feed roller mechanism, a measuring wheel resiliently mounted on the delimbing head, and a trimsaw movably mounted on the delimbing head. The length of the processed tree extending beyond the delimbing head may be calculated from signals encoded by the log feed roller mechanism and the measuring wheel. Logs may be cut from the tree by the trimsaw. Two photosensors located at known positions may be used to calculate the total length of the tree.Type: ApplicationFiled: November 30, 2006Publication date: June 5, 2008Applicant: RISLEY ENTERPRISES LTD.Inventors: Reggald Emory ISLEY, Peter STEGMEIER