Patents by Inventor Peter Sutovsky
Peter Sutovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210270815Abstract: Disclosed herein are methods for determining the fertility of a sperm sample or a source of a sperm sample; the methods comprising labeling the sperm sample with a zinc probe, identifying presence and/or localization of zinc associated with spermatozoa in the sample and determining the fertility of the sample based on the zinc presence and/or localization in the spermatozoa as compared to a reference pattern associated with non-capacitated spermatozoa or a reference pattern associated with sperm capacitation. Also disclosed are methods of improving sperm fertility and/or decreasing premature capacitation while handling, storing, or transporting semen, the methods comprising adding exogenous zinc to a sperm sample or semen sample. Also disclosed are compositions for improving sperm fertility and/or reducing premature capacitation, the compositions comprising exogenous zinc ions.Type: ApplicationFiled: May 17, 2019Publication date: September 2, 2021Inventors: PETER SUTOVSKY, MICHAL ZIGO, KARL KERNS, MIRIAM SUTOVSKY
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Patent number: 10485584Abstract: Media, kits, and methods for cultivation of mammalian embryos from fertilized oocyte stage to blastocyst stage in the presence of N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine. The use of this supplement improves the early embryonic development, in particular the quality of zygotes and the blastocyst formation. The supplemented media can be used with pigs, humans, or other mammals N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine may be added to known media, and used for with vitro fertilization methods.Type: GrantFiled: June 8, 2017Date of Patent: November 26, 2019Assignees: Lekarska fakulta v Plzni, Univerzita Karlova (Faculty of Medicine in Pilsen, Charles University), The Curators of the University of Missouri, Chonbuk National University, Division of Biotechnology, College of Environmental and Bioresources, Ceska zemedelska univerzita v Praze, Institute of Animal ScienceInventors: Jan Nevoral, Young-Joo Yi, Katerina Zamostna-Adamkova, Jaroslav Petr, Peter Sutovsky, Milena Kralickova
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Publication number: 20180353209Abstract: Media, kits, and methods for cultivation of mammalian embryos from fertilized oocyte stage to blastocyst stage in the presence of N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine. The use of this supplement improves the early embryonic development, in particular the quality of zygotes and the blastocyst formation. The supplemented media can be used with pigs, humans, or other mammals N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine may be added to known media, and used for with vitro fertilization methods.Type: ApplicationFiled: June 8, 2017Publication date: December 13, 2018Applicants: Lekarska fakulta v Plzni, Univerzita Karlova (Faculty of Medicine in Pilsen, Charles Univ), The Curators of the University of Missouri, Chonbuk National Univ, Division of Biotechnology, College of Environmental and Bioresources, Ceska zemedelska univerzita v Praze, Institute of Animal ScienceInventors: Jan Nevoral, Young-Joo Yi, Katerina Zamostna-Adamkova, Jaroslav Petr, Peter Sutovsky, Milena Kralickova
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Patent number: 10070889Abstract: The present invention provides a new and improved sperm stimulating additive comprising a certain amount of inorganic pyrophosphate (PPi). Addition of PPi in the media for human/animal in vitro fertilization (IVF) improves fertilization rate; addition of PPi in the semen extender for farm animal artificial insemination (AI) may improve pregnancy rates; furthermore, mammalian oocytes matured in vitro in a medium including PPi attain improved fertilization and developmental potential, while embryos cultured in medium supplemented with PPi have improved development to blastocyst.Type: GrantFiled: May 29, 2014Date of Patent: September 11, 2018Assignee: The Curators of the University of MissouriInventors: Peter Sutovsky, Young-Joo Yi
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Patent number: 9594077Abstract: The present invention provides a new apparatus/system for determining fertility of mammalian sperm based on a specific sperm-binding test that mimics sperm binding to an egg. The inventive apparatus/system comprises surface-modified beads with a compound or conjugates containing a carbohydrate sequence associated with the mammalian zona-pellucida (ZP) glycoproteins.Type: GrantFiled: July 3, 2013Date of Patent: March 14, 2017Assignee: The Curators of the University of MissouriInventors: Gary Francis Clark, Peter Sutovsky
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Publication number: 20150168382Abstract: The present invention provides a new apparatus/system for determining fertility of mammalian sperm based on a specific sperm-binding test that mimics sperm binding to an egg. The inventive apparatus/system comprises surface-modified beads with a compound or conjugates containing a carbohydrate sequence associated with the mammalian zona-pellucida (ZP) glycoproteins.Type: ApplicationFiled: July 3, 2013Publication date: June 18, 2015Inventors: Gary Francis Clark, Peter Sutovsky
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Publication number: 20140350329Abstract: The present invention provides a new and improved sperm stimulating additive comprising a certain amount of inorganic pyrophosphate (PPi). Addition of PPi in the media for human/animal in vitro fertilization (IVF) improves fertilization rate; addition of PPi in the semen extender for farm animal artificial insemination (AI) may improve pregnancy rates; furthermore, mamalian oocytes matured in vitro in a medium including PPi attain improved fertilization and developmental potential, while embryos cultured in medium supplemented with PPi have improved development to blastocyst.Type: ApplicationFiled: May 29, 2014Publication date: November 27, 2014Applicant: The Curators of the University of MissouriInventors: Peter Sutovsky, Young-Joo Yi
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Patent number: 8771934Abstract: The present invention provides a new and improved sperm stimulating additive comprising a certain amount of inorganic pyrophosphate (PPi). Addition of PPi in the media for human/animal in vitro fertilization (IVF) improves fertilization rate; addition of PPi in the semen extender for farm animal artificial insemination (AI) may improve pregnancy rates; furthermore, mammalian oocytes matured in vitro in a medium including PPi attain improved fertilization and developmental potential, while embryos cultured in medium supplemented with PPi have improved development to blastocyst.Type: GrantFiled: December 7, 2012Date of Patent: July 8, 2014Assignee: The Curators of the University of MissouriInventors: Peter Sutovsky, Young-Joo Yi
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Patent number: 8501099Abstract: An example system for detecting an analyte in a sample of a bodily fluid comprises a test chamber having at least one sidewall and configured to contain at least a portion of a bodily fluid sample, an excitation electromagnetic energy source configured to direct an energy source into the test chamber through the at least one sidewall and to induce a thermoelastic expansion in the one or more analytes, and a sensor configured to detect said thermoelastic expansion in the bodily fluid sample in the test chamber, the sensor configured to measure changes in optical reflectance that result from the thermoelastic expansion.Type: GrantFiled: December 31, 2008Date of Patent: August 6, 2013Assignee: The Curators of the University of MissouriInventors: John A. Viator, Paul S. Dale, Ryan M. Weight, Peter Sutovsky
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Patent number: 8293176Abstract: An example method for detecting an analyte in a sample of a bodily fluid includes the steps of exposing the bodily fluid sample to electromagnetic energy to cause a thermoelastic expansion in the analyte, and detecting a photoacoustic signal in the sample that results from the thermoelastic expansion.Type: GrantFiled: May 18, 2011Date of Patent: October 23, 2012Assignee: The Curators of the University of MissouriInventors: John A. Viator, Paul S. Dale, Ryan M. Weight, Peter Sutovsky
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Patent number: 8021852Abstract: The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fertility marker. Sptrx-3 may be detected in accordance with the invention in vitro or in vivo.Type: GrantFiled: June 14, 2010Date of Patent: September 20, 2011Assignee: The Curators of the University of MissouriInventors: Peter Sutovsky, Antonio Miranda-Vizuete
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Publication number: 20110217762Abstract: An example method for detecting an analyte in a sample of a bodily fluid comprises the steps of exposing the bodily fluid sample to electromagnetic energy to cause a thermoelastic expansion in the analyte, and detecting a photoacoustic signal in the sample that results from the thermoelastic expansion.Type: ApplicationFiled: May 18, 2011Publication date: September 8, 2011Applicant: The Curators of the University of MissouriInventors: John A. Viator, Paul S. Dale, Ryan M. Weight, Peter Sutovsky
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Patent number: 7968347Abstract: An example method for detecting an analyte in a sample of a bodily fluid comprises the steps of exposing the bodily fluid sample to electromagnetic energy to cause a thermoelastic expansion in the analyte, and detecting a photoacoustic signal in the sample that results from the thermoelastic expansion.Type: GrantFiled: July 11, 2007Date of Patent: June 28, 2011Assignee: The Curators of the University of MissouriInventors: John A. Viator, Paul S. Dale, Ryan M. Weight, Peter Sutovsky
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Publication number: 20100317013Abstract: The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fertility marker. Sptrx-3 may be detected in accordance with the invention in vitro or in vivo.Type: ApplicationFiled: June 14, 2010Publication date: December 16, 2010Inventors: Peter Sutovsky, Antonio Miranda-Vizuete
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Publication number: 20100233249Abstract: The present invention concerns the use of compositions and methods of regulating or evaluating fertility in an animal, in particular a mammal. In various embodiments of the invention, methods of contraception include inhibiting proteasome activity of a gamete, in particular spermatozoon. Proteasomal activity may be inhibited in vitro or in vivo. Inhibitors of the proteasome pathway include, but are not limited to small molecules, peptides, polypeptides (e.g., antibodies and the like) and affinity reagents that bind various components of the proteasome pathway (e.g., aptamers, etc.). In some embodiments, the activity of the proteasome pathway or the activity of a component in the proteasome pathway is inhibited by antibodies that bind and inhibit one or more components of the proteasome pathway.Type: ApplicationFiled: December 29, 2009Publication date: September 16, 2010Inventors: Peter Sutovsky, Billy N. Day, Tod C. McCauley, Miriam Sutovsky
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Patent number: 7741058Abstract: The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fertility marker. Sptrx-3 may be detected in accordance with the invention in vitro or in vivo.Type: GrantFiled: July 25, 2008Date of Patent: June 22, 2010Assignee: The Curators of the University of MissouriInventors: Peter Sutovsky, Antonio Miranda-Vizuete
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Publication number: 20090170149Abstract: An example system for detecting an analyte in a sample of a bodily fluid comprises a test chamber having at least one sidewall and configured to contain at least a portion of a bodily fluid sample, an excitation electromagnetic energy source configured to direct an energy source into the test chamber through the at least one sidewall and to induce a thermoelastic expansion in the one or more analytes, and a sensor configured to detect said thermoelastic expansion in the bodily fluid sample in the test chamber, the sensor configured to measure changes in optical reflectance that result from the thermoelastic expansion.Type: ApplicationFiled: December 31, 2008Publication date: July 2, 2009Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: John A. Viator, Paul S. Dale, Ryan M. Weight, Peter Sutovsky
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Publication number: 20090053717Abstract: The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fertility marker. Sptrx-3 may be detected in accordance with the invention in vitro or in vivo.Type: ApplicationFiled: July 25, 2008Publication date: February 26, 2009Inventors: Peter Sutovsky, Antonio Miranda-Vizuete
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Patent number: 7485430Abstract: The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fertility marker. Sptrx-3 may be detected in accordance with the invention in vitro or in vivo.Type: GrantFiled: April 15, 2005Date of Patent: February 3, 2009Assignee: The Curators of the University of MissouriInventors: Peter Sutovsky, Antonio Miranda-Vizuete
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Patent number: 7384913Abstract: The perinuclear theca 32 (PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of enhancing fertility, treating or diagnosing diminished fertility and abnormal spermiogenesis, in providing contraception, and in identifying contraceptive and fertility-enhancing agents. Transgenic, non-human animals also are disclosed.Type: GrantFiled: September 12, 2005Date of Patent: June 10, 2008Assignees: Queen's University at Kingston, Oregon Health Sciences UniversityInventors: Richard Oko, Peter Sutovsky