Patents by Inventor Peter Szentmiklosi
Peter Szentmiklosi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5244880Abstract: The invention relates to novel stable aqueous primycin solutions containing 0.5 to 1.75% by mass/volume of primycin sulfate or 2.5 to 9% by mass/volume of a complex of primycin N-methylpyrrolidone and 2 to 15% by mass/volume of pyroglutamic acid, preferably L-pyroglutamic acid or a soluble salt, preferably the sodium salt thereof as calculated for the volume of the solution to be prepared and 40 to 60% by volume of isopropanol as calculated for the volume of the solution to be prepared as well as water in an amount adding up to 100%. The stable, aqueous primycin solutions are topical antibiotics.Type: GrantFiled: February 11, 1992Date of Patent: September 14, 1993Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek GyaraInventors: Peter Szentmiklosi, Tamas Szuts, Gyorgy Hidasi, Istvan Juhasz
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Patent number: 5064815Abstract: This invention relates to a primycin-containing colloidal basic gel comprising 5-30% of primycin and 95-70% of N-methyl-pyrrolidone-2. The invention also relates to antibacterial compositions particularly for the treatment of acne vulgaris comprising as active ingredient 0.1-100% of a primycin-containing colloidal basic gel, if desired together with further antimicrobial active ingredients, in admixture with 99.9-0% of usual inert pharmaceutical filling, diluting and other formulating additives. The invention also relates to combination composition comprising as active ingredient 1-60% of a primycin-containing colloidal basic gel and 0.1-40% of further pharmaceutical active ingredient(s), e.g. one or more antibiotic(s), chemotherapeutical agent(s), fungistatic or fungicidal agent(s), steroidal or non-steroidal antiinflammatory agent (s), epithelogenic agent(s), local anaesthetic(s), and/or vitamin(s).Type: GrantFiled: March 26, 1990Date of Patent: November 12, 1991Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Peter Szentmiklosi, Tamas Szuts, Jozsef Nemes, Jozsef Lengyel, Jeno Marton, Peter Sarkozi, Erzsebet Babos nee Vajas, Eniko Schreiner nee Kovats
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Patent number: 4921707Abstract: The invention relates to the production of a new pharmaceutical preparation of high acid-binding capacity, of delayed effect, of increased bioavailability for neutralization of gastric acid and eventually to other pharmaceutical preparations acting in the gastrointestinal tract, first of all of laxative effect by mixing 100 parts by mass of a powdered basic magnesium compound or the powdered mixture of basic magnesium compounds and basic aluminum compounds with 2-2500 parts of a dry or water-swollen organic acid of polymeric character and therapeutically acceptable, e.g. cellulose-glycolic acid, starch-glycolic acid or polymer acrylic and/or methacrylic acid, letting this powdered mixture to stand for 1-24 hours at the temperature of 20.degree.-80.degree. C.Type: GrantFiled: March 28, 1988Date of Patent: May 1, 1990Inventors: Istvan Racz, Janos Plachy, Peter Szentmiklosi
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Patent number: 4814336Abstract: A new method of treatment is disclosed for a vascular obstructive lesion resulting from restricted blood circulation, characterized by an erythrocyte pathology, in an effected animal subject. The new method involves the administration of 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinolinium-theophylli ne-7-acetat e, in a dosage and at a rate sufficient to maintain a blood concentration of at least 0.5 to at most 3 .gamma./ml, calculated on the basis of 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinoline.Type: GrantFiled: December 3, 1986Date of Patent: March 21, 1989Assignee: CHINOIN Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Peter Szentmiklosi, Istvan Hermecz, Zoltan Meszaros, Laszo Tardos, Jeno Marton, Lelle Vasvari (nee Debreczy), Agnes Horvath, Katalin Marmarosi (nee Kellner)
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Patent number: 4670440Abstract: N,N,N-trimethyl-2-hydroxyethyl-ammonium-[1-ethyl-6-fluoro-4-oxo-7-(1-pipera zinyl)-1,4-dihydro-quinolizine-3-carboxylate] of the formula I ##STR1## as a norfloxacin antimicrobial salt capable of enteral administration.Type: GrantFiled: April 21, 1986Date of Patent: June 2, 1987Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Tamas Szuts, Peter Szentmiklosi, Jozsef Lengyel, Istvan Hermecz, Lelle Vasvari nee Debreczy, Agnes Horvath, Geza Kerszturi, Gabor Kovacs, Gabor Horvath, Katalin Marmarosi nee Kellner
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Patent number: 4666912Abstract: The invention relates to a process for the restoration and prevention of gastrointestinal injuries, which comprises treating a patient with an effective dose of racemic or optically active 1,6-dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrimido[1,2-a]pyrimidine-3-c arboxamide.Type: GrantFiled: March 22, 1985Date of Patent: May 19, 1987Assignee: Chinoin Gyogyszer es Vegyeszeti Termeker Gyara RTInventors: Zoltan Meszaros, Jozse Knoll, Istvan Hurmecz, Peter Szentmiklosi, Agnes Horvath, Lelle Vasvari nee Debreczy, Gabor Kovacs, Klara Gyires, Sandor Virag
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Patent number: 4495189Abstract: New compounds of the following formula are disclosed:1,6-dimethyl-3-carbamoyl-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2-a)-pyrimidi ne;1,6-dimethyl-3-(N-tertiary-butyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyr ido(1,2-a)pyrimidine;1,6-dimethyl-3-(N-2-phenethyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido (1,2-a)pyrimidine;1,6-dimethyl-3-[N-(3,3-diphenyl-propyl)-carbamoyl]-4-oxo-1,6,7,8-tetrahydro -4H-pyrido(1,2-a)pyrimidine;1,6-dimethyl-3-(N-phenyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2- a)pyrimidine; and1,6-dimethyl-3-(N-methyl-carbamoyl)-4-oxo-1,6,7,8-tetrahydro-4H-pyrido(1,2- a)pyrimidine, as well as pharmaceutical compositions containing these compounds and a method of inhibiting thrombocyte aggregation in mammals employing a pharmaceutically effective amount of at least one of these compounds.Type: GrantFiled: April 2, 1982Date of Patent: January 22, 1985Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Zoltan Meszaros, Jozsef Knoll, Peter Szentmiklosi, Istvan Hermecz, Agnes Horvath, Sandor Virag, Lelle Vasvari, Agoston David
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Patent number: 4460771Abstract: New optionally racemic or optically active pyrimido(1,2a) heterocyclic compounds of the formula ##STR1## wherein m is 0, 1 or 2,n is 0, 1 or 2,R is an alkyl group containing one to six carbon atoms,R.sup.1 is hydrogen, alkyl containing one to six carbon atoms,R.sup.2 is hydrogen, alkyl containing one to six carbon atoms, optionally substituted amino, optionally substituted hydroxy, carboxy or a group derived from a carboxylic acid orR.sup.1 and R.sup.2 together form a --(CH.dbd.CH).sub.2 -- group attached to the two adjacent carbon atoms of the ring A and the broken line represents a chemical bond,R.sup.3 is hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocycle, optionally substituted cycloalkyl, optionally substituted acyl or optionally substituted hydroxy,R.sup.Type: GrantFiled: November 17, 1976Date of Patent: July 17, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Zoltan Meszaros, Jozsef Knoll, Peter Szentmiklosi, Istvan Hermes, Agnes Horvath, Sandor Virag, Lelle Vasvari nee Debreczy, Agoston David
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Patent number: 4291036Abstract: Compounds of the formula ##STR1## or pharmaceutically acceptable acid-addition or quaternart ammonium salts thereofwhereinR is hydroxy, carboxy, lower alkoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl, carbamoyl, N-loweralkyl-carbamoyl, N,N-dilower-alkyl-carbamoyl, carboazido, carbohydrazido or cyano;R.sup.2 is C.sub.1 to C.sub.6 alkyl;R.sup.3 is C.sub.1 to C.sub.6 alkyl or benzyl; andR.sup.4 is a single electron pair, hydrogen or lower alkyl; and the dotted lines represent saturated or unsaturated bonds, are disclosed with analgesic properties.Type: GrantFiled: March 14, 1980Date of Patent: September 22, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Jozsef Knoll, Zoltan Meszaros, Istvan Hermecz, Ferenc Fulop, Gabor Bernath, Sandor Virag, Gabor Nagy, Peter Szentmiklosi
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Patent number: 4219649Abstract: Compounds of the formula: ##STR1## or pharmaceutically acceptable acid addition or quaternary ammonium salts thereofwhereinR.sup.2 is C.sub.1 to C.sub.6 alkyl:R.sup.3 is C.sub.1 to C.sub.6 alkyl;R.sup.4 is a single electron pair, hydrogen or lower alkyl; and the dotted lines indicate saturated or unsaturated bonds, are disclosed with analgesic properties.Type: GrantFiled: August 17, 1978Date of Patent: August 26, 1980Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Josef Knoll, Zoltan Meszaros, Istvan Hermecz, Ferenc Fulop, Gabor Bernath, Sandor Virag, Gabor Nagy, Peter Szentmiklosi
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Patent number: 4199560Abstract: The present invention relates to a solid oral pharmaceutical preparation with protracted release of the active ingredient consisting of discrete solid granules containing the active ingredient soluble in the stomach and auxiliary agents and of an equally solid external phase surrounding the said granules, whereby the granules forming the internal phase consist of granules prepared from a powder mixture which contains as active ingredient, or in addition to it a non-toxic metal compound, being capable of binding an acid, and being insoluble or but slightly soluble in neutral aqueous medium--particularly bismuth, aluminium or magnesium compound--and auxiliary materials prepared with an aqueous emulsion containing a hydrophobic component and hydrophylic emulsifiers, and the external phase contains a solid, dry, amphoteric gel forming substance in an amount of 1-50 percent w/w related to the total weight of the preparation in admixture with auxiliary agents.Type: GrantFiled: October 19, 1978Date of Patent: April 22, 1980Assignee: Novex Talalmanyfejleszto Es Ertekesito Kulkereskedelmi RtInventors: Laszlo Gyarmati, Istvan Racz, Peter Szentmiklosi, Janos Plachy
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Patent number: 4035366Abstract: 1-Benzal-1,2,3,4-tetrahydro-isoquinolinium-theophylline-7-acetates are used in the manufacture of geriatric compositions.Type: GrantFiled: January 22, 1974Date of Patent: July 12, 1977Assignee: Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara RTInventors: Peter Szentmiklosi, Zoltan Meszaros, Laszlo Tardos, Istvan Hermecz, Ilona Erdelyi, Agoston David, Lelle Vasvari nee Debreczy, Agnes Horvath
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Patent number: 4027024Abstract: Pharmaceutical compositions of synergistic analgesic activity are provided which comprise an azido compound of the following formula: ##STR1## or a salt thereof wherein R is hydrogen, methyl, ethyl, acetyl or morpholino-methyl and a compound of the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 are hydrogen or lower alkyl and the dotted lines represent hydrogenated bonds or olefinic bonds and pharmaceutically acceptable salts and quaternary salts thereof, in admixture with suitable inert solid or liquid carriers or dilutents.Type: GrantFiled: January 15, 1976Date of Patent: May 31, 1977Assignee: Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara RTInventors: Jozsef Knoll, Zsuzsanna Furst, Zoltan Meszaros, Peter Szentmiklosi, Agoston David, Istvan Hermecz, Attila Mandi, Rezso Bognar, Sandor Makleit, Gyula Valovics, Laszlo Szavik, Sandor Nagy
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Patent number: 3954986Abstract: An analgesic substitute for morphine comprising the synergistic combination of azidomorphine or azidocodeine with a pyrimidazolium.Type: GrantFiled: November 14, 1973Date of Patent: May 4, 1976Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Jozsef Knoll, Zsuzsanna Furst, Zoltan Meszaros, Peter Szentmiklosi, Agoston David, Istvan Hermecz, Attila Mandi, Rezso Bognar, Sandor Makleit, Gyula Valovics, Laszlo Szlavik, Sandor Nagy