Patents by Inventor Peter Thornton
Peter Thornton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230242639Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.Type: ApplicationFiled: February 7, 2023Publication date: August 3, 2023Inventors: Claire DOBSON, Richard WILLIAMS, Ian GURRELL, Sadhana PODICHETTY, David FAIRMAN, Peter THORNTON, Philip NEWTON
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Patent number: 11591389Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.Type: GrantFiled: September 29, 2020Date of Patent: February 28, 2023Assignee: MEDIMMUNE LIMITEDInventors: Claire Dobson, Richard Williams, Ian Gurrell, Sadhana Podichetty, David Fairman, Peter Thornton, Philip Newton
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Patent number: 11504089Abstract: An adaptor for adjusting electrical signals propagated along an electrically-conductive path between a drive unit and a catheter of an intravascular ultrasound imaging system includes a catheter connector disposed along a first end of a housing and configured to receive the catheter. A drive-unit connector is disposed along a second end of the housing and is configured to couple the adaptor to the drive unit. A catheter-conductor interface electrically-couples to a transducer conductor of the catheter. A drive-unit-conductor interface electrically-couples to an electrical conductor of the drive unit. An adaptor conductor electrically-couples the catheter-conductor interface to the drive-unit-conductor interface. A tuning element is electrically-coupled to the adaptor conductor and is configured to adjust electrical signals propagating along the adaptor conductor based, at least in part, on an operational frequency of a transducer disposed in the catheter.Type: GrantFiled: September 25, 2018Date of Patent: November 22, 2022Assignee: Boston Scientific Scimed, Inc.Inventor: Peter Thornton, Jr.
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Patent number: 11058307Abstract: Medical devices including optical connector cable assemblies are disclosed. An optical connector cable assembly may include an optical connector cable having a first optical fiber extending therefrom. The optical connector cable may include a distal connector configured to connect to a guidewire. The distal connector may include an inner housing and a guidewire locking mechanism. The distal connector may also include an actuator. Actuation of the actuator may move the inner housing from a first position to a second position. When the inner housing is in the first position the guidewire locking mechanism is configured to secure the guidewire and the guidewire is rotatable with respect to the optical connector cable. When the inner housing is in the second position the guidewire locking mechanism is in an open state for receiving or removing the guidewire.Type: GrantFiled: February 22, 2017Date of Patent: July 13, 2021Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Misha Young, Peter Thornton, Jr., Alfonso D'Alessandro, Corey Higham
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Publication number: 20210061905Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.Type: ApplicationFiled: September 29, 2020Publication date: March 4, 2021Inventors: Claire Dobson, Richard Williams, Ian Gurrell, Sadhana Podichetty, David Fairman, Peter Thornton, Philip Newton
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Patent number: 10836822Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.Type: GrantFiled: March 16, 2018Date of Patent: November 17, 2020Assignee: MedImmune LimitedInventors: Claire Dobson, Richard Williams, Ian Gurrell, Sadhana Podichetty, David Fairman, Peter Thornton, Philip Newton
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Publication number: 20200121286Abstract: A catheter for an ultrasound system can a marker disposed on the hub. The marker is optically or magnetically readable and, when read, identifies the catheter. A drive unit can include an optical or magnetic marker reader. Alternatively or additionally, a catheter may include an active memory arrangement that can be read by an appropriate reader on the drive unit.Type: ApplicationFiled: October 19, 2018Publication date: April 23, 2020Inventors: Joe Corrigan, Peter Thornton, JR.
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Publication number: 20200121280Abstract: A catheter assembly for an ultrasound system can include an integrated pullback arrangement. For example, the catheter assembly can include a telescoping pullback section having a first telescope, a second telescope, a distal grip coupling one of the first or second telescope to the distal sheath of the distal section, and a proximal grip coupled to another of the first or second telescope so that the first telescope can be retracted into the second telescope and a sensor to determine a position of the first telescope. Another example includes the sensor and a pullback slider arrangement having a housing defining a slit, a coupler disposed within the housing, and a slider handle extending through the slit and coupled to the coupler. In another example, the coupler and housing can be gripped and slid relative to each other.Type: ApplicationFiled: December 17, 2019Publication date: April 23, 2020Inventors: John D. Marshall, Peter Thornton, JR., Lewis J. Thomas, III, Isaac J. Zacharias, Gaylin Mildred Yee
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Patent number: 10499820Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a system for measuring blood pressure. The system may include a pressure sensing guidewire including a pressure sensor and a first optical fiber extending proximally from the pressure sensor. The system may also include an optical connector cable including a distal connector capable of being coupled to the guidewire. The optical connector cable may include a second optical fiber that is capable of optically communicating with the first optical fiber. A coupler may be disposed within the distal connector and disposed between the first optical fiber and the second optical fiber.Type: GrantFiled: May 22, 2014Date of Patent: December 10, 2019Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Roger W. McGowan, Christopher Smuk, Peter Thornton, Jr.
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Publication number: 20190090844Abstract: An adaptor for adjusting electrical signals propagated along an electrically-conductive path between a drive unit and a catheter of an intravascular ultrasound imaging system includes a catheter connector disposed along a first end of a housing and configured to receive the catheter. A drive-unit connector is disposed along a second end of the housing and is configured to couple the adaptor to the drive unit. A catheter-conductor interface electrically-couples to a transducer conductor of the catheter. A drive-unit-conductor interface electrically-couples to an electrical conductor of the drive unit. An adaptor conductor electrically-couples the catheter-conductor interface to the drive-unit-conductor interface. A tuning element is electrically-coupled to the adaptor conductor and is configured to adjust electrical signals propagating along the adaptor conductor based, at least in part, on an operational frequency of a transducer disposed in the catheter.Type: ApplicationFiled: September 25, 2018Publication date: March 28, 2019Inventor: Peter Thornton, JR.
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Publication number: 20180305450Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.Type: ApplicationFiled: March 16, 2018Publication date: October 25, 2018Inventors: Claire Dobson, Richard Williams, Ian Gurrell, Sadhana Podichetty, David Fairman, Peter Thornton, Philip Newton
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Publication number: 20170238822Abstract: Medical devices including optical connector cable assemblies are disclosed. An optical connector cable assembly may include an optical connector cable having a first optical fiber extending therefrom. The optical connector cable may include a distal connector configured to connect to a guidewire. The distal connector may include an inner housing and a guidewire locking mechanism. The distal connector may also include an actuator. Actuation of the actuator may move the inner housing from a first position to a second position. When the inner housing is in the first position the guidewire locking mechanism is configured to secure the guidewire and the guidewire is rotatable with respect to the optical connector cable. When the inner housing is in the second position the guidewire locking mechanism is in an open state for receiving or removing the guidewire.Type: ApplicationFiled: February 22, 2017Publication date: August 24, 2017Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: MISHA YOUNG, PETER THORNTON, JR., ALFONSO D'ALESSANDRO, COREY HIGHAM
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Publication number: 20170164925Abstract: A catheter assembly for an ultrasound system can include an integrated pullback arrangement. For example, the catheter assembly can include a telescoping pullback section having a first telescope, a second telescope, a distal grip coupling one of the first or second telescope to the distal sheath of the distal section, and a proximal grip coupled to another of the first or second telescope so that the first telescope can be retracted into the second telescope and a sensor to determine a position of the first telescope. Another example includes the sensor and a pullback slider arrangement having a housing defining a slit, a coupler disposed within the housing, and a slider handle extending through the slit and coupled to the coupler. In another example, the coupler and housing can be gripped and slid relative to each other.Type: ApplicationFiled: October 4, 2016Publication date: June 15, 2017Inventors: John D. Marshall, Peter Thornton, JR., Lewis J. Thomas, III, Isaac J. Zacharias, Gaylin Mildred Yee
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Patent number: 9563023Abstract: An example medical device system includes a reusable connector cable having a female adaptor and a first fiber optic cable disposed within the reusable connector cable. A single use device is capable of connecting to the reusable connector cable and includes a male adaptor capable of mating with the female adaptor. A second fiber optic cable extends through the single use device such that the second fiber optic cable optically connects to the first fiber optic cable when the male adaptor of the single use device is disposed within the female adaptor of the reusable connector cable. A cleaning assembly is disposed within the single use device and is capable of cleaning an end of the first fiber optic cable when the male adaptor of the single use device is mated with the female adaptor of the reusable connector cable.Type: GrantFiled: July 28, 2016Date of Patent: February 7, 2017Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventor: Peter Thornton, Jr.
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Publication number: 20160334585Abstract: An example medical device system includes a reusable connector cable having a female adaptor and a first fiber optic cable disposed within the reusable connector cable. A single use device is capable of connecting to the reusable connector cable and includes a male adaptor capable of mating with the female adaptor. A second fiber optic cable extends through the single use device such that the second fiber optic cable optically connects to the first fiber optic cable when the male adaptor of the single use device is disposed within the female adaptor of the reusable connector cable. A cleaning assembly is disposed within the single use device and is capable of cleaning an end of the first fiber optic cable when the male adaptor of the single use device is mated with the female adaptor of the reusable connector cable.Type: ApplicationFiled: July 28, 2016Publication date: November 17, 2016Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventor: PETER THORNTON, JR.
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Patent number: 9429713Abstract: An example medical device system includes a reusable connector cable having a female adaptor and a first fiber optic cable disposed within the reusable connector cable. A single use device is capable of connecting to the reusable connector cable and includes a male adaptor capable of mating with the female adaptor. A second fiber optic cable extends through the single use device such that the second fiber optic cable optically connects to the first fiber optic cable when the male adaptor of the single use device is disposed within the female adaptor of the reusable connector cable. A cleaning assembly is disposed within the single use device and is capable of cleaning an end of the first fiber optic cable when the male adaptor of the single use device is mated with the female adaptor of the reusable connector cable.Type: GrantFiled: April 14, 2015Date of Patent: August 30, 2016Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventor: Peter Thornton, Jr.
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Publication number: 20150301288Abstract: An example medical device system includes a reusable connector cable having a female adaptor and a first fiber optic cable disposed within the reusable connector cable. A single use device is capable of connecting to the reusable connector cable and includes a male adaptor capable of mating with the female adaptor. A second fiber optic cable extends through the single use device such that the second fiber optic cable optically connects to the first fiber optic cable when the male adaptor of the single use device is disposed within the female adaptor of the reusable connector cable. A cleaning assembly is disposed within the single use device and is capable of cleaning an end of the first fiber optic cable when the male adaptor of the single use device is mated with the female adaptor of the reusable connector cable.Type: ApplicationFiled: April 14, 2015Publication date: October 22, 2015Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventor: PETER THORNTON, JR.
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Publication number: 20140350414Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a system for measuring blood pressure. The system may include a pressure sensing guidewire including a pressure sensor and a first optical fiber extending proximally from the pressure sensor. The system may also include an optical connector cable including a distal connector capable of being coupled to the guidewire. The optical connector cable may include a second optical fiber that is capable of optically communicating with the first optical fiber. A coupler may be disposed within the distal connector and disposed between the first optical fiber and the second optical fiber.Type: ApplicationFiled: May 22, 2014Publication date: November 27, 2014Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: ROGER W. MCGOWAN, CHRISTOPHER SMUK, PETER THORNTON, JR.
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Publication number: 20140343601Abstract: Systems and methods for treating internal tissue defects, such as septal defects, with clip-based devices are provided. An exemplary clip-based device includes a tubular body having at least a first and a second deflectable member coupled thereto. The first and second members are coupled on opposite ends of the tubular body and configured to deflect between an undeployed configuration and a deployed configuration. In the deployed configuration, each member extends outwardly away from the tubular body in a position configured to abut a tissue surface. The first and second members are preferably configured to maintain a tissue wall therebetween and at least partially close any opening in the tissue wall.Type: ApplicationFiled: April 7, 2014Publication date: November 20, 2014Applicant: PROMED, INC.Inventors: Ryan Abbott, W. Martin Belef, Dean Carson, Peter Fitzgerald, Ronald J. Jabba, James Nielson, Peter Thornton
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Patent number: 8882782Abstract: An atherectomy device and method has cannula systems having lumens adapted for insertion of a blood filter and an atherectomy catheter useful for performing atherectomy directly on a patient's cardiovascular tissue. Other embodiments include a lumen for arterial perfusion useful in providing oxygenated blood to the aorta during cardiopulmonary bypass. The distal end of the atherectomy catheter includes an assembly that has a pincer, a loop with or without a mesh, laser, hydraulics, or other suitable mechanism adapted for removing atheroma from a cardiac or vascular tissue. Methods of using the systems for vascular atherectomy are also disclosed herein.Type: GrantFiled: October 7, 2013Date of Patent: November 11, 2014Assignee: Edwards Lifesciences CorporationInventor: Peter Thornton