Abstract: A fluid dispensing system for delivering sterile preservative-free solution is disclosed. The system uses double self-sealing valves mounted in series inside a tip compartment which fits on the outlet of a multiple dosage squeeze container to prevent undesirable retrograde flow of the dispensed liquid back into the bottle during the decompression cycle. The valves used are either positive acting, normally closed duckbill and/or umbrella valve(s) which open to express solution from the container when squeezing pressure is applied to the bottle and which automatically close when the pressure is released. The fluid dispensing system with an umbrella valve near the system outlet has close to zero dead space volume thereby practically eliminated possible contamination of the sterile fluid under the circumferential seal head portion of the umbrella valve and in the container. A hydrophobic filter is provided to sterilize the replacement air which enters the container upon release of the squeezing pressure.

Abstract: A fluid dispensing system for delivering sterile preservative free solution is disclosed. The system uses double self-sealing valves mounted in series inside a tip compartment which fits on the outlet of a multiple dosage squeeze container to prevent undesirable retrograde flow of the dispensed liquid back into the bottle during the decompression cycle. The valves used are positive acting, normally closed duckbill valves which open to express solution from the container when squeezing pressure is applied to the bottle and which automatically close when the pressure is released. A hydrophobic filter is provided to sterilize the replacement air which enters the container upon release of the squeezing pressure.

Abstract: There is disclosed a dispensing container for dispensing sterile liquid medicament, for example into the eyes, e.g., liquid artificial tears, in which a filter is provided in the dispensing nozzle or in a closure member for the container having pores which are sufficiently small to filter out microorganisms, whereby an antibacterial agent need not be included in the medicament. A cap is provided for the dispensing nozzle, which cap may have an absorbent pad impregnated with an antibacterial agent to maintain the exit port of the dispensing nozzle sterile. The container may also have a filter provided in a vent in a wall thereof, whereby air drawn into the container to replace liquid medicament ejected through the nozzle thereof will be sterilized. The filter preferably comprises a plurality of hollow elongated filter fibers or tubes bent back on themselves and secured in the nozzle or closure member by a suitable potting material, having in any case pores not larger than about 0.2 micron in diameter.