Abstract: The present invention relates to nanoparticles comprising nucleic acids coated with a (biodegradable) polymer for reversible immobilization and/or controlled release of the nucleic acid comprising nanoparticles. Furthermore, the present invention is directed to medical or diagnostic devices, particularly stents and implants coated by a (biodegradable) polymer with the nucleic acid comprising nanoparticles for reversible immobilization and/or controlled release. Furthermore, the present invention is directed to the use of these nanoparticles coated with a (biodegradable) polymer and to the use of medical devices and implants coated by the (biodegradable) polymer with these nucleic acid comprising nanoparticles in the prophylactic or therapeutic treatment of diseases, particularly in the prevention or treatment of restenosis, calicification, foreign body reaction, or inflammation.

Abstract: In a method for sharing health care information, a computing system of a care receiver receives first data, including a voice message, from a computing system of a caregiver. Based on the first data, the care receiver's computing system determines a notification time associated with the voice message. The care receiver's computing system causes a speaker to generate the voice message at the notification time, and listens for a response from the care receiver. The care receiver's computing system receives, from the care receiver via a microphone at the care receiver's computing system, a voice response message, and sends second data including the voice response message to the computing system of the caregiver.

Abstract: The invention relates to a polyribonucleotide, a cosmetic and pharmaceutical compound that has the polyribonucleotide and a medicinal product that has the polyribonucleotide and the compound.

Abstract: The invention relates to a medical device for use in human vessels, in particular in the carotid artery, comprising: a self-expandable mesh structure which at least partially forms a curved wall, and has, in a radially compressed state, a cross-sectional diameter of not more than 2.5 mm, wherein the mesh structure is formed of at least one mesh structural element which has a height that is no more than 200 ?m, in particular no more than 150 ?m, preferably no more than 70 ?m, where the height is measurable along a diameter of the mesh structure, and wherein the mesh structure is at least partially formed of a nickel titanium alloy and is at least partially coated in fibrin.

Abstract: The present invention relates to nanoparticles comprising nucleic acids coated with a (biodegradable) polymer for reversible immobilization and/or controlled release of the nucleic acid comprising nanoparticles. Furthermore, the present invention is directed to medical or diagnostic devices, particularly stents and implants coated by a (biodegradable) polymer with the nucleic acid comprising nanoparticles for reversible immobilization and/or controlled release. Furthermore, the present invention is directed to the use of these nanoparticles coated with a (biodegradable) polymer and to the use of medical devices and implants coated by the (biodegradable) polymer with these nucleic acid comprising nanoparticles in the prophylactic or therapeutic treatment of diseases, particularly in the prevention or treatment of restenosis, calicification, foreign body reaction, or inflammation.

Abstract: The invention relates to a polyribonucleotide, a cosmetic and pharmaceutical compound that has the polyribonucleotide and a medicinal product that has the polyribonucleotide and the compound.

Abstract: A composition for cleaning, disinfecting, protective treatment, or a combination thereof of technical surfaces contains microparticles loaded with an antibacterially effective ingredient. The antibacterially effective ingredient can be totarol. Microparticles loaded with totarol can be used for the coating of medical implants. Medical implants coated with a composition for cleaning, disinfecting, protective treatment or a combination thereof are provided.

Abstract: The present invention relates to nanoparticles comprising nucleic acids coated with a (biodegradable) polymer for reversible immobilization and/or controlled release of the nucleic acid comprising nanoparticles. Furthermore, the present invention is directed to medical or diagnostic devices, particularly stents and implants coated by a (biodegradable) polymer with the nucleic acid comprising nanoparticles for reversible immobilization and/or controlled release. Furthermore, the present invention is directed to the use of these nanoparticles coated with a (biodegradable) polymer and to the use of medical devices and implants coated by the (biodegradable) polymer with these nucleic acid comprising nanoparticles in the prophylactic or therapeutic treatment of diseases, particularly in the prevention or treatment of restenosis, calicification, foreign body reaction, or inflammation.

Abstract: The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia.

Abstract: The invention relates to a device comprising at least one surface which comes into contact with biological tissue and/or liquid, which is at least partially coated with a substance which mediates the binding of mesenchymal stem cells (MSCs), a method for the binding and/or isolation of MSCs from biological tissue and/or liquid, a nucleic acid molecule which selectively and highly specifically binds to MSCs, the use of the nucleic acid molecule for the binding and/or isolation of MSCs from biological tissue and/or liquid, as well as a method for the production of a device mentioned at the outset.

Abstract: The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia.

Abstract: The present invention relates to a sealing plug for an opening in a wall of a vessel or hollow organ of an animal or human body, in particular a blood vessel, to a device for placing such a sealing plug in such an opening, to a surgery kit for percutaneously sealing an opening in a wall of a vessel or hollow organ of an animal or human body, in particular a blood vessel, and to a method for percutaneously sealing of an opening in a wall of a vessel or hollow organ of an animal or human body.

Abstract: Devices having at least one surface which comes into contact with tissues and/or fluids of the human or animal body. These surfaces are at least partially coated with aptamers, which mediate the adhesion of biological material.

Abstract: The invention relates to a process for preparing compounds of the formula I In this process a 2-aminobenzothiophene-3-carboxylic ester of the formula II is reacted with a nitrile of the formula III N≡C—R1   III in solution or suspension in a solvent in the presence of an acid.

Abstract: The invention relates to a process for preparing compounds of the formula I 1

Abstract: An arresting brake device with triggering equipment for elevators provides different braking effect in upward and downward directions of travel. The device includes a tiltable rocker, as a barrier element, provided with an articulated two-point bearing in yielding joint pans. The rocker is operatively connected with a movable brake shoe and is, on actuation by triggering equipment, tilted by entraining members up to an abutment beyond or ahead of its dead center according to the direction of travel of an elevator car in upward or downward directions. By the tilting movement, one or the other yielding joint pan is pushed against a biased adjustable compression spring and the movable brake shoe and a fixed brake shoe are accordingly urged against a guide rail. The compression springs, which are arranged in a spring block, can each be biased separately in a variable manner by a respective setting screw.

Abstract: A process is proposed for controlling an automatic transmission (3), in which at least one of the weighted values: selector lever activity, excess engine torque, curve radius and brake activity determines a first parameter (K1), the driving activity. Besides the first parameter (K1), a second parameter (K2) determines the selection of a shift characteristic field (31) among a plurality of shift characteristic fields. The second parameter (K2) is determined according to a driving state: city traffic (27), trailering (28) and mountain driving (29).

Abstract: A process is disclosed for electronically controlling an automatic transmission in which the torque transmission is reduced when the engine throttle setting and vehicle speed are below a threshold. The transmitted torque causes the vehicle to creep slightly, warning the driver that a gear is engaged. The slant and load of the vehicle are taken into account for controlling the drive torque.

Abstract: Apparatus for making stencils of the type having a rectangular frame and a woven fabric stretched upon and affixed to the frame for use in a screen printing machine has a table which supports four rows of neighboring fabric stretching devices surrounding a rectangular portion of the upper side of the table. Each stretching device has a support the underside of which abuts the upper side of the table, and a double-acting hydraulic or pneumatic cylinder and piston unit pivoted to the support and having a piston rod extendable toward and retractable away from the frame at the rectangular portion of the upper side of the table. The free end of each piston rod carries tongs having a pair of fabric-engaging jaws which stretch the fabric during retraction of the respective piston rod.

Abstract: In order to adapt the shifting characteristics of an electrohydraulically controlled, automatically shifting transmission continuously to the dirver's driving style or to a just existing or real time traffic situation, the driving speed (v), the lateral acceleration (aq), the longitudinal acceleration (alb), the longitudinal deceleration (alv) and the engine rotational speed (nmot) in addition to the throttle valve position alpha, are detected and by way of characteristic diagrams and a linking function are added to form a parameter from which, by filtering, a driving activity is determined. This driving activity is finally used for the selection of a shifting program from a plurality of shifting programs ranging from a consumption-optimized shifting program (SKF1) to a power-optimized shifting program (SKF5).