Patents by Inventor Peter William Sheldrake
Peter William Sheldrake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9371319Abstract: The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as “PPA derivatives”), particularly 1H-pyrrolo[3,2-c]pyridine-6-amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them.Type: GrantFiled: March 14, 2012Date of Patent: June 21, 2016Assignee: CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Vassilios Bavetsias, Butrus Atrash, Sebastien Gaston Andre Naud, Peter William Sheldrake, Julian Blagg
-
Publication number: 20130345181Abstract: The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as “PPA derivatives”), particularly 1H-pyrrolo[3,2-c]pyridine-6-amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them.Type: ApplicationFiled: March 14, 2012Publication date: December 26, 2013Applicant: CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Vassilios Bavetsias, Butrus Atrash, Sébastien Gaston André Naud, Peter William Sheldrake, Julian Blagg
-
Patent number: 8592581Abstract: The present invention relates to compounds of formula (I) wherein: R1 and R2 are each independently H, alkyl or haloalkyl; R3 and R4 are each independently H, alkyl, haloalkyl or aryl; R5 is alkyl or cycloalkyl or cycloalkyl-alkyl, each of which may be optionally substituted with one or more OH groups; R6 is selected from cyclopropylamino, cyclopropylmethylamino, cyclobutylamino, cyclobutylmethylamino and where one of X, Y and Z is N and the remainder are CR9; R7, R8 and each R9 are independently H, alkyl or haloalkyl, wherein at least one of R7, R8 and each R9 is other than H. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula (I), and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.Type: GrantFiled: October 5, 2009Date of Patent: November 26, 2013Assignees: Cyclacel Limited, Cancer Research Technology LimitedInventors: Peter William Sheldrake, Butrus Atrash, Simon Green, Edward McDonald, Sheelagh Frame
-
Publication number: 20100093769Abstract: The present invention relates to compounds of formula (I) wherein: R1 and R2 are each independently H, alkyl or haloalkyl; R3 and R4 are each independently H, alkyl, haloalkyl or aryl; R5 is alkyl or cycloalkyl or cycloalkyl-alkyl, each of which may be optionally substituted with one or more OH groups; R6 is selected from cyclopropylamino, cyclopropylmethylamino, cyclobutylamino, cyclobutylmethylamino and where one of X, Y and Z is N and the remainder are CR9; R7, R8 and each R9 are independently H, alkyl or haloalkyl, wherein at least one of R7, R8 and each R9 is other than H. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula (I), and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.Type: ApplicationFiled: October 5, 2009Publication date: April 15, 2010Applicants: CYCLACEL LIMITED, CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Peter William SHELDRAKE, Butrus ATRASH, Simon GREEN, Edward MCDONALD, Sheelagh FRAME
-
Publication number: 20020188122Abstract: Novel 1, 4, 5- substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.Type: ApplicationFiled: February 27, 2001Publication date: December 12, 2002Applicant: SmithKline Beecham CorporationInventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
-
Patent number: 6150557Abstract: Novel 1, 4, 5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.Type: GrantFiled: November 3, 1998Date of Patent: November 21, 2000Assignee: SmithKline Beecham CorporationInventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
-
Patent number: 6103936Abstract: The present invention is to a novel process for the preparation of a compound of the formula: ##STR1## wherein p is 0, or 2;Ar is an optionally substituted phenyl or naphtyl; andinter alia R4 is an optionally susbtituted phenyl, naphth-1-yl, naphth-2-yl, or a heteroaryl ring;which process comprises reacting together an aldehyde of the formula:R.sub.4 --CHO;wherein R.sub.4 is as defined above;a compound of the formula:ArS(O)pH;wherein Ar, and p are as defined above;with formamide, an acid catalyst, and optionally a dehydrating agent.Type: GrantFiled: March 17, 1997Date of Patent: August 15, 2000Assignee: SmithKline Beecham CorporationInventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravishanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
-
Patent number: 5969184Abstract: The present invention is directed to the novel intermediate compounds of the formula: ##STR1## wherein, interalia, R.sub.4 is a substituted phenyl or an optionally substituted napthyl derivative.Type: GrantFiled: May 9, 1997Date of Patent: October 19, 1999Assignee: SmithKline Beecham CorporationInventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
-
Patent number: 5726315Abstract: The compounds of the invention are tri-substituted pyridine intermediates, useful in the preparation of final products, wherein said final products are involved in the preparation of medicaments. Said medicaments are useful for the treatment of various diseases including psoriasis. A compound of the formula (II): ##STR1## wherein R.sup.1 is hydrogen, benzyl or a group of the formula (A): ##STR2## in which n is 1 to 20; and R.sup.5 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or trifluoromethyl; and R.sup.7 is a leaving group consisting of halogen, OTf or (Trifluorate, e.g. OSO.sub.2 CF.sub.3), OSO.sub.2 alkyl and OSO.sub.2 Ar wherein Ar represents optionally substituted aryl.Type: GrantFiled: May 23, 1996Date of Patent: March 10, 1998Assignee: SmithKline Beecham plcInventors: Peter William Sheldrake, Laurence Charles Powling, Peter William Bickle
-
Patent number: 5663334Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.Type: GrantFiled: August 21, 1996Date of Patent: September 2, 1997Assignee: SmithKline Beecham CorporationInventors: Peter William Sheldrake, Timothy Francis Gallagher, Joseph Sisko
-
Patent number: 5646286Abstract: This invention involves a coupling reaction involving an organo-metallic catalyst, preferably a palladium catalyst involving reacting 2-halo-3-hydroxy-6-hydroxymethylpyridine, acrylic acid or its alkali metal salt and benzyl or a phenylalkyl derivative in presence of a dipolar aprotic solvent producing none other than the expected 2-propenoate-3-benzyl or phenylalkylether-6-hydroxymethyl-pyridine product. Said products are converted into medicaments useful for treating psoriasis.Type: GrantFiled: May 26, 1995Date of Patent: July 8, 1997Assignee: SmithKline Beecham plcInventors: Peter William Sheldrake, Laurence Charles Powling, Peter William Bickle