Abstract: Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The anchor points of the artificial chordae can be offset from the apex of the heart to achieve a targeted force vector on the annulus. In addition, some embodiments include distal anchors implanted in the posterior leaflet in addition to those at the posterior annulus. This allows differential tensioning to be applied to provide for greater flexibility in treating various configurations of mitral valves to improve coaptation.

Abstract: A dry powder inhaler with a blister folding device can include a housing to receive a single blister containing a dose of medicament for inhalation by a user, and a mouthpiece through which a dose of medicament is inhaled by a user and a blister opening device. The blister opening device can include a blister support element for supporting a blister containing a dose of medicament for inhalation by a user, and a blister folding element co-operable with the blister support element. The blister folding element and the blister support element can be movable relative to each other between a first position, for insertion of the blister into or onto the blister support element, and a second, burst, position in which the blister folding element has co-operated with the blister support element.

Abstract: Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral valve using an edge-to-edge repair to secure the mitral valve leaflets. Implant securing devices are also described that can be used during a procedure to repair a mitral valve. In some embodiments, an implant securing device includes an outer member and an inner member movably disposed within the outer member. The inner member can be used to hold or secure a suture extending from an implant deployed on an atrial side of a leaflet of a mitral valve, and the outer member can be used to push or move a half hitch knot toward a ventricular side of the leaflet, which can be used to secure the implant in the desired position.

Abstract: A semi-disposable face mask has a shaped molded base composed of silicone and/or TPE and molded forming a face seal, a filter media and a support structure that houses the shaped molded base and filter media in fluid communication allowing airflow from an environment through the filter media to the face seal.

Abstract: The present disclosure relates to hydrogels and their use for repairing or supplementing body tissue. The hydrogels are capable of safe injection into patients through fine gauge needles and are suitable for repairing, supplementing, or replacing the nucleus pulposus of an intervertebral disc. Methods of manufacturing and methods of using the hydrogels of the present disclosure to repair or replace tissues are also disclosed.

Abstract: Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral valve using an edge-to-edge repair to secure the mitral valve leaflets. Implant securing devices are also described that can be used during a procedure to repair a mitral valve. In some embodiments, an implant securing device includes an outer member and an inner member movably disposed within the outer member. The inner member can be used to hold or secure a suture extending from an implant deployed on an atrial side of a leaflet of a mitral valve, and the outer member can be used to push or move a half hitch knot toward a ventricular side of the leaflet, which can be used to secure the implant in the desired position.

Abstract: A control unit for a medical device wherein the control unit comprises a pump, a conduit and control means for controlling the flow of fluid from the pump through the conduit; and wherein the conduit is a rigid internal passage located in the control unit.

Abstract: A cap configured to be worn on a wearer's head includes a crown characterized by a substantially elliptical opening that has a circumference and one or more radii normal to the circumference, a bill connected to the crown, and a substantially elliptical sweatband connected to the crown. The sweatband has a front portion that is compliant in a radial direction and a back portion that is flexible in an axial direction. The front portion includes a front contact layer configured to be in contact with the wearer's head, a concealed backing layer adjacent to the crown, and a compliant layer between the front contact layer and the concealed backing layer. The compliant layer is compliant in the radial direction. The back portion has a rear contact layer configured to be in contact with the wearer's head and a concealed support layer.

Abstract: A method and system for personal protective equipment, such as a respirator mask, having a nosecup that is removably coupled to the item of personal protective equipment by at least one of an electronics housing and at least one voicemitter. A respirator mask includes a frame including a voicemitter aperture, a voicemitter, and a nosecup removably coupled to the frame by a rotation of the voicemitter by a predetermined amount to removably lock the nosecup to the frame voicemitter aperture. The mask further includes electronics components, which are housed in an annular electronics housing located within the front portion of the mask body 14 and in contact with a front portion of the nosecup. The nosecup may further be removably coupled to the mask frame by coupling between the annular electronics housing and the mask frame.

Abstract: A respiratory mask includes a body configured to cover a nose and a mouth of a user. The body includes a face seal configured to at least partially seal the body to a face of the user. The face seal includes a standard reflex seal that is configured to engage in physical contact with the face to form a first segment of a seal between the body and the face. The face seal also includes a reverse reflex seal that is configured to engage in physical contact with the face to form a second segment of a seal between the body and the face. This configuration allows the mask body to float in place with respect to the face seal and preserves the seal between the mask and the face, even when the user is talking or moving his or her face.

Abstract: A method for promoting contraception by placing a contraceptive device within a uterus without blocking fallopian tubes may involve advancing a distal end of a delivery device through a cervix, advancing the contraceptive device comprising an elongate shape memory member out of the distal end of the delivery device and into the uterus, and limiting inferior migration of the contraceptive device within the uterus. Inferior migration may be limited by allowing the contraceptive device to assume a shape, when subjected to pressure that tends to cause a downward migration of the device within the uterus, in which an expandable middle portion of the device is expanded to contact the inner wall of the uterus and thus limit the downward migration of the device.

Abstract: A power supply for an item of personal protective equipment and a method and system for removably coupling the power supply to the item of personal protective equipment, such as a respirator mask. The removable battery cartridge is attached to the mask body in the user's chin area, below the location at which a respirator would be or is attached. Thus, the power supply (battery cartridge) is out of the user's way and is at a location that allow the user to couple or uncouple the cartridge from the mask quickly and easily, even when the user is wearing gloves. In one embodiment, a mask body includes a lower surface and power supply that is removably couplable to the mask body lower surface.

Abstract: Described herein are methods and apparatus for approximating targeted tissue using locking sutures. The locking sutures can be configured to receive suture ends that are interweaved through portions of the locking sutures. In a pre-deployment configuration, a locking suture can slide along suture tails and can be positioned at a target location within a target region. Once a desired position and/or tension is achieved, the locking suture can be transitioned to a post-deployment configuration where the locking suture constricts around the suture tails to inhibit relative movement between the suture tails and the locking suture.

Abstract: Disclosed herein is an in-mask display or feedback system having a lens coupled to a face blank of the mask, the lens covering a facepiece. The feedback system includes a display apparatus coupled to the facepiece, and disposed within an interior of the mask, the display apparatus being powered by a first power source coupled to a housing of the display apparatus. The feedback system further includes a recording device (e.g., a camera) coupled to the face blank, the recording device operable to communicate data (e.g., wirelessly or wired) with the display apparatus. In some approaches, the recording device is powered by a second power source. In other approaches, the first power source provides power to both the recording device and the display apparatus. In another approach, the display apparatus includes an adjustment aperture formed therethrough to allow adjustment of an eye piece housing a display.

Abstract: A method linear friction welds a rotor blade to a disk. The method includes: providing a linear friction welding machine having disk tooling at which a disk is mounted, and further having blade tooling at which a blade is mountable; mounting a dummy blade at blade tooling, dummy blade carrying one or more first measurement devices which interact with mounted disk to measure position of dummy blade relative to disk; adjusting position and orientation of blade tooling relative to mounted disk until first measurement devices indicate that dummy blade is in a suitable alignment with disk to start linear friction welding a blade to disk; releasing dummy blade from blade tooling and mounting a production blade thereat; and linear friction welding the production blade to the disk with the blade tooling starting at adjusted position and orientation.

Abstract: There is disclosed a back-brace assistive device for supporting a proper lifting posture of a user, including a back-brace assembly featuring a series of interconnected and articulating vertebrae assemblies, as well as an upper back plate assembly and a lower back plate assembly, each in connection with the series of the vertebrae assemblies. Each vertebrae assembly fits into the adjacent assembly via a ball joint, and the series of the vertebrae assemblies couples with the upper and the lower back plate assemblies via additional ball joints. At least one support component extends from the upper back plate assembly, across the series of the articulating vertebrae assemblies, to the lower back plate assembly to provide rigidity and articulation support for the vertebrae assemblies. An anchoring mechanism such as a harness attaches to the back-brace assembly to secure the back-brace assembly to the user's back. Other embodiments are also disclosed.

Abstract: In some embodiments, an apparatus includes a needle, a pusher, a distal anchor having a distal end, a proximal end, a plurality of radially expandable members between the distal end and the proximal end, and a central bore, and an artificial chordae having a proximal portion and a distal portion terminating in a stopper. The pusher is disposed within a bore of the needle for movement between a delivery position and a deployed position. The distal anchor is disposed within the bore of the needle in a delivery configuration and movable between a delivery position and a deployed position. The artificial chordae is disposed within the bore of the distal anchor with the stopper distal to a distal end of the stopper and the proximal portion proximal to the proximal end of the distal anchor. The distal anchor is reconfigurable from the delivery configuration to a deployed configuration.

Abstract: A method for promoting contraception by placing a contraceptive device within a uterus without blocking fallopian tubes may involve advancing a distal end of a delivery device through a cervix, advancing the contraceptive device comprising an elongate shape memory member out of the distal end of the delivery device and into the uterus, and limiting inferior migration of the contraceptive device within the uterus. Inferior migration may be limited by allowing the contraceptive device to assume a shape, when subjected to pressure that tends to cause a downward migration of the device within the uterus, in which an expandable middle portion of the device is expanded to contact the inner wall of the uterus and thus limit the downward migration of the device.

Abstract: A method for promoting contraception by placing a contraceptive device within a uterus without blocking fallopian tubes may involve advancing a distal end of a delivery device through a cervix, advancing the contraceptive device comprising an elongate shape memory member out of the distal end of the delivery device and into the uterus, and limiting inferior migration of the contraceptive device within the uterus. Inferior migration may be limited by allowing the contraceptive device to assume a shape, when subjected to pressure that tends to cause a downward migration of the device within the uterus, in which an expandable middle portion of the device is expanded to contact the inner wall of the uterus and thus limit the downward migration of the device.