Abstract: The invention relates to a device (100) for identifying biotic particles in a medium to be analyzed, comprising a measuring cell (104), through which the medium to be analyzed can flow and in which the identification of the biotic particles is carried out by means of Raman spectroscopy, and a feed (102) by means of which the medium to be analyzed can be fed to the measuring cell (104). The device (100) according to the invention is characterized in that the feed (102) comprises at least one sensor (101) with which the presence of biotic particles in the medium flowing through the feed (102) can be ascertained. The feed (102) has a controllable bypass valve (103) downstream of the sensor (101), and the medium can be selectively fed to the measuring cell (104) or to a bypass channel (106) via said bypass valve.

Abstract: A method in which the cleavage profile and size distribution of von Willebrand factor (VWF) multimers is analyzed, includes: providing a sample medium of human body fluids comprising a plurality of VWF multimers of different size; enrichment or purification of the VWF multimers by cryoprecipitation or chromatography to obtain a separated preparation of the VWF multimers from said sample medium; exposing the separated preparation of VWF multimers to a light source to produce signals obtained by vibrational spectroscopy; detecting said signals; transformation by mathematical alogrithms; generation of patterns based on computing of data of original resonance spectra and determining the cleavage profile and the size distribution of said separated VWF multimers by chemometrics; and acquisition of a databank obtained from healthy individuals for identifying subjects at risk of developing at least one of the following diseases: sepsis, coagulopathy, thrombotic disease, infection, and inflammation.