Abstract: The present invention relates to a new multifunctional debridement and/or antifouling composition comprising H2O2 at a final concentration of between 0.1-5% v/v, and a composite hydrogel formulation comprising pluronic acid at a concentration of 10-40% w/v, wherein the composition is in liquid form at room temperature. The composition disclosed herein is antimicrobial and/or anti-inflammatory and is particular useful in periimplantitis treatment and implant health maintenance, in periodontitis and periodontal health and in wound care and chronic ulcer care.

Abstract: Aspects of the present invention relate to an improved antimicrobial and/or anti-viral composition comprising an antimicrobial and/or anti viral mixture consisting of: H2O2 at a final concentration of between 3-7% v/v, and a poloxamer at a concentration of 0.1-10% w/v. The poloxamer is in a composite hydrogel formulation. The composition disclosed herein is antimicrobial and/or anti-viral and is particularly useful for cleaning, sterilizing, disinfecting, sanitizing, decontaminating and/or debriding biological surfaces and surfaces of biomaterials, such as when provided in a hand sanitizer, mouth wash, nasal rinse and/or for wound care and/or chronic ulcer care and use for dental prophylaxis and peri-implant health maintenance.

Abstract: The present invention deals with a bone implant matrix comprising a base matrix selected from the group comprising: —acellularized or acellularized non-demineralised bone matrix of any source, —matrix of natural mineral sources, —synthetic bioceramics matrix, or combinations of the above, wherein the surface of said base matrix is coated with an statistically homo-geneous composition which is a reinforcing mixture containing at least a bio-degradable polyester or co-polymer thereof, at least a gelatine or hydrolysed gelatine and at least an artificial Proline-Rich Peptide.

Abstract: The present invention is directed to a debridement and/or implant cleaning tool 1 in which the means for cleaning 4 is made of a biodegradable material. Thus, if parts of the means for cleaning 4 come loose during use, these will be degraded by natural processes in the body and will not remain in the body and cause negative body reactions.

Abstract: The present invention is directed to a debridement and/or implant cleaning tool 1 in which the means for cleaning 4 is made of a biodegradable material. Thus, if parts of the means for cleaning 4 come loose during use, these will be degraded by natural processes in the body and will not remain in the body and cause negative body reactions.

Abstract: The present invention is directed to a debridement and/or implant cleaning tool (1) in which the means for cleaning (4) is made of a biodegradable material. Thus, if parts of the means for cleaning (4) come loose during use, these will be degraded by natural processes in the body and will not remain in the body and cause negative body reactions.

Abstract: The present invention relates to a new and inventive composition for implant cleaning and/or debridement of hard surfaces in the oral cavity, which comprises optimally activated nanoparticles of TiO2, having a mean particle diameter (D50) of about 10-100 nm at a concentration between 0.5-500 g/L, and H2O2, at a concentration of at the most 7.5% by volume, said composition being antibacterial, without causing microbial resistance, and anti-inflammatory, and wherein said composition further comprises solid microparticles, having a mean particle diameter (D50) of about 100-200 ?m at a concentration between 0.5-300 g/L, for improved mechanical debridement and/or cleaning of rough surfaces in the oral cavity and/or on an implant.

Abstract: The present disclosure is directed to a titanium dioxide scaffold provided with a nanoporous outer layer which can function as a cortical wall, inhibiting growth of soft tissue into the scaffold and increasing its mechanical strength. The disclosure is also directed to a process for producing such a nanoporous outer layer and the application of the titanium dioxide scaffold with the nanoporous outer layer as a medical implant.

Abstract: The present document is directed to medical implants in the form of titanium dioxide scaffolds. Disclosed is a method for producing titanium dioxide scaffolds having an increased mechanical strength by recoating the titanium dioxide scaffold with a low viscosity titanium dioxide slurry in a vacuum infiltration process followed by sintering of the scaffold. The document is also directed to the recoated titanium dioxide scaffolds produced and their uses as medical implants.

Abstract: A body fluid purifying arrangement comprises a purifying chamber having a fluid input and a fluid output, a first filter arranged in connection the fluid input, and a second filter arranged in connection with the fluid output. In another embodiment, a body fluid purifying arrangement in the form of a syringe comprises a purifying chamber having a common fluid input and fluid output, and a filter arranged in connection with the common fluid input and output. Granules or particles made of a metal or an oxide of a metal are retained within the purifying chamber by the respective filter(s) to purify a body fluid passing through the purifying chamber from 10 kDa interferon-? inducible protein, IP-10, wherein said metal is a metal of group 4 or 5 of the periodic table of the elements and selected from the group consisting of titanium, zirconium, hafnium, niobium and tantalum.

Abstract: A method of treating or preventing a disease characterized by adverse expression and/or release of 10 kDa interferon-? inducible protein, IP-10, comprises administering granules or particles made of a metal or an oxide of a metal to a subject suffering from the disease. A method of reducing IP-10 in a subject suffering from a disease characterized by adverse expression and/or release of IP-10 comprises administering granules or particles made of a metal or an oxide of a metal to the subject. The metal is a metal of group 4 or 5 of the periodic table of the elements and selected from the group consisting of titanium, zirconium, hafnium, niobium and tantalum.

Abstract: The present document is directed to a titanium dioxide scaffold comprising a hydrogel coating comprising a biologically active substance. Also disclosed is a method for producing a thin hydrogel coating on a titanium dioxide scaffold and uses of the hydrogel coated scaffolds as medical implants.

Abstract: The present invention relates to a metal oxide scaffold comprising titanium oxide. The scaffolds of the invention are useful for implantation into a subject for tissue regeneration and for providing a framework for cell growth and stabilization to the regenerating tissue. The invention also relates to methods for producing such metal oxide scaffolds and their uses.

Abstract: A kit having a) a cleaning device, the cleaning device (1) including an elongated base member (2) formed of at least two wires (3) being twisted with each other, and a plurality of bristles (4) fixed between the twisted wires (3) and extending away from the twisted wires (3), whereby the bristles (4) are positioned in a cleaning section (5) at a first end (6) of the base member (2); wherein the bristles (4) consist of titanium or a titanium alloy; and b) a container having a composition including ethylene diaminotetraacetic acid (EDTA) is disclosed. A method for cleaning and/or debriding and/or conditioning a biological mineralized surface and/or a biological soft tissue surface and/or a dental implant is also disclosed. Additionally, there is disclosed a method for preventing and/or treating a condition in a patient in need of such treatment.

Abstract: Disclosed are medical prosthetic device or medical implants which exhibit improved biocompatibility. The devices or implants include a metal material, e.g., titanium, in which the metal surfaces are coated with a corresponding hydride material that contains one or more biomolecule substance. The biomolecule substance may contain one or more biologically active molecules, e.g., bio-adhesives, biopolymers, blood proteins, enzymes, extracellular matrix proteins, extracellular matrix biomolecules, growth factors and hormones, peptide hormones, deoxyribonucleic acids, ribonucleic acids, receptors, inhibitors, drugs, biologically active anions and cations; vitamins; adenosine monophosphate (AMP), adenosine diphosphate (ADP) or adenosine triphosphate (ATP), marker biomolecules, amino acids, fatty acids, nucleotides (RNA and DNA bases), or sugars.

Abstract: The present document is directed to a titanium dioxide scaffold comprising a hydrogel coating comprising a biologically active substance. Also disclosed is a method for producing a thin hydrogel coating on a titanium dioxide scaffold and uses of the hydrogel coated scaffolds as medical implants.

Abstract: The present disclosure is directed to a titanium dioxide scaffold provided with a nanoporous outer layer which can function as a cortical wall, inhibiting growth of soft tissue into the scaffold and increasing its mechanical strength. The disclosure is also directed to a process for producing such a nanoporous outer layer and the application of the titanium dioxide scaffold with the nanoporous outer layer as a medical implant.

Abstract: The present document is directed to medical implants in the form of titanium dioxide scaffolds. Disclosed is a method for producing titanium dioxide scaffolds having an increased mechanical strength by recoating the titanium dioxide scaffold with a low viscosity titanium dioxide slurry in a vacuum infiltration process followed by sintering of the scaffold. The document is also directed to the recoated titanium dioxide scaffolds produced and their uses as medical implants.

Abstract: The present document is directed to medical prosthetic devices used for implantation to replace and/or restore lost functions in a body. The document discloses a method for producing an alginate coated titanium dioxide scaffold wherein the alginate coating optionally comprises a biologically active substance.

Abstract: The present invention relates to a metal oxide scaffold comprising titanium oxide. The scaffolds of the invention are useful for implantation into a subject for tissue regeneration and for providing a framework for cell growth and stabilization to the regenerating tissue. The invention also relates to methods for producing such metal oxide scaffolds and their uses.