Patents by Inventor Philip A. Lessard

Philip A. Lessard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11932864
    Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.
    Type: Grant
    Filed: May 19, 2022
    Date of Patent: March 19, 2024
    Assignee: AGRIVIDA INC.
    Inventors: R. Michael Raab, Oleg Bougri, Matthew Parker, Philip A. Lessard
  • Publication number: 20220315939
    Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.
    Type: Application
    Filed: May 20, 2022
    Publication date: October 6, 2022
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Oleg BOUGRI, Philip A. LESSARD, Christopher BONIN, Michael B. LANAHAN
  • Publication number: 20220282269
    Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.
    Type: Application
    Filed: May 19, 2022
    Publication date: September 8, 2022
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Oleg BOUGRI, Matthew PARKER, Philip A. LESSARD
  • Patent number: 11390879
    Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: July 19, 2022
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Oleg Bougri, Matthew Parker, Philip A. Lessard
  • Patent number: 11371052
    Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: June 28, 2022
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Oleg Bougri, Philip A. Lessard, Christopher Bonin, Michael B. Lanahan
  • Publication number: 20200299709
    Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.
    Type: Application
    Filed: November 3, 2017
    Publication date: September 24, 2020
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Oleg BOUGRI, Philip A. LESSARD, Christopher BONIN, Michael B. LANAHAN
  • Publication number: 20200071716
    Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.
    Type: Application
    Filed: May 29, 2018
    Publication date: March 5, 2020
    Applicant: AGRIVIDA, INC.
    Inventors: R. Michael RAAB, Oleg BOUGRI, Matthew PARKER, Philip A. LESSARD
  • Patent number: 10407742
    Abstract: Intein modified proteins, isolated nucleic acids encoding intein modified proteins, fragments of intein modified proteins, isolated nucleic acids encoding fragments of intein modified proteins, transgenic plants containing any of the foregoing, and antibodies recognizing epitopes on intein modified proteins are provided.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: September 10, 2019
    Assignee: Agrivida, Inc.
    Inventors: Binzhang Shen, Gabor Lazar, Humberto de la Vega, Philip Lessard, R. Michael Raab, James Apgar
  • Patent number: 10196623
    Abstract: A method of predicting an intein insertion site in a protein that will lead to a switching phenotype is provided. The method includes identifying a plurality of C/T/S sites within the protein; selecting from the plurality of C/T/S/sites those that are ranked 0.75 or higher by a support vector machine, within ten angstroms of the active site of the protein, and at or near a loop-?-sheet junction or a loop-?-helix junction. A method of controlling protein activity and hosts including proteins with controlled activity are also provided. Also, intein modified proteins and plants containing intein modified proteins are provided.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: February 5, 2019
    Assignee: AGRIVIDA, INC.
    Inventors: Binzhang Shen, Gabor Lazar, Humberto de la Vega, James Apgar, Philip Lessard, R. Michael Raab
  • Patent number: 9598700
    Abstract: Genetically engineered plants having altered levels of one or more starch regulation enzymes and a polysaccharide degrading enzyme are provided. Methods of genetically engineering plants to express products altering expression of one or more starch regulation enzymes and polysaccharide degrading enzymes, and genetic constructs are provided. Methods of agricultural processing and animal feed using the genetically engineered plants are described.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: March 21, 2017
    Assignee: Agrivida, Inc.
    Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab, Dongcheng Zhang
  • Patent number: 9464333
    Abstract: A method of predicting an intein insertion site in a protein that will lead to a switching phenotype is provided. The method includes identifying a plurality of C/T/S sites within the protein; selecting from the plurality of C/T/S/ sites those that are ranked 0.75 or higher by a support vector machine, within ten angstroms of the active site of the protein, and at or near a loop-?-sheet junction or a loop-?-helix junction. A method of controlling protein activity and hosts including proteins with controlled activity are also provided. Also, intein modified proteins and plants containing intein modified proteins are provided.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: October 11, 2016
    Assignee: Agrivida, Inc.
    Inventors: James Apgar, Philip Lessard, R. Michael Raab, Binzhang Shen, Gabor Lazar, Humberto de la Vega
  • Patent number: 9434954
    Abstract: Vectors for altering the expression of one or more starch regulation enzymes are provided. Methods of transformation of plant tissues to express elements altering expression of one or more starch regulation enzymes, and resulting transgenic plants are provided. Methods of using the transgenic plants are provided.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: September 6, 2016
    Assignee: Agrivida, Inc.
    Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab
  • Publication number: 20160186157
    Abstract: A method of predicting an intein insertion site in a protein that will lead to a switching phenotype is provided. The method includes identifying a plurality of C/T/S sites within the protein; selecting from the plurality of C/T/S/sites those that are ranked 0.75 or higher by a support vector machine, within ten angstroms of the active site of the protein, and at or near a loop-?-sheet junction or a loop-?-helix junction. A method of controlling protein activity and hosts including proteins with controlled activity are also provided. Also, intein modified proteins and plants containing intein modified proteins are provided.
    Type: Application
    Filed: January 20, 2016
    Publication date: June 30, 2016
    Applicant: AGRIVIDA, INC.
    Inventors: BINZHANG SHEN, GABOR LAZAR, HUMBERTO DE LA VEGA, JAMES APGAR, PHILIP LESSARD, R. MICHAEL RAAB
  • Patent number: 9303250
    Abstract: A method of predicting an intein insertion site in a protein that will lead to a switching phenotype is provided. The method includes identifying a plurality of C/T/S sites within the protein; selecting from the plurality of C/T/S/ sites those that are ranked 0.75 or higher by a support vector machine, within ten angstroms of the active site of the protein, and at or near a loop-?-sheet junction or a loop-?-helix junction. A method of controlling protein activity and hosts including proteins with controlled activity are also provided. Also, intein modified proteins and plants containing intein modified proteins are provided.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: April 5, 2016
    Assignee: Agrivida, Inc.
    Inventors: Binzhang Shen, Gabor Lazar, Humberto de la Vega, James Apgar, Philip Lessard, R. Michael Raab
  • Publication number: 20130318656
    Abstract: Vectors for altering the expression of one or more starch regulation enzymes are provided. Methods of transformation of plant tissues to express elements altering expression of one or more starch regulation enzymes, and resulting transgenic plants are provided. Methods of using the transgenic plants are provided.
    Type: Application
    Filed: June 27, 2011
    Publication date: November 28, 2013
    Applicant: Agrivida, Inc.
    Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab
  • Publication number: 20130269061
    Abstract: Genetically engineered plants having altered levels of one or more starch regulation enzymes and a polysaccharide degrading enzyme are provided. Methods of genetically engineering plants to express products altering expression of one or more starch regulation enzymes and polysaccharide degrading enzymes, and genetic constructs are provided. Methods of agricultural processing and animal feed using the genetically engineered plants are described.
    Type: Application
    Filed: March 11, 2013
    Publication date: October 10, 2013
    Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab, Dongcheng Zhang
  • Publication number: 20130247251
    Abstract: A method of predicting an intein insertion site in a protein that will lead to a switching phenotype is provided. The method includes identifying a plurality of C/T/S sites within the protein; selecting from the plurality of C/T/S/ sites those that are ranked 0.75 or higher by a support vector machine, within ten angstroms of the active site of the protein, and at or near a loop-?-sheet junction or a loop-?-helix junction. A method of controlling protein activity and hosts including proteins with controlled activity are also provided. Also, intein modified proteins and plants containing intein modified proteins are provided.
    Type: Application
    Filed: February 26, 2013
    Publication date: September 19, 2013
    Applicant: AGRIVIDA, INC.
    Inventors: Binzhang Shen, Gabor Lazar, Humberto de la Vega, James Apgar, Philip Lessard, R. Michael Raab
  • Patent number: 8420387
    Abstract: A method of predicting an intein insertion site in a protein that will lead to a switching phenotype is provided. The method includes identifying a plurality of C/T/S sites within the protein; selecting from the plurality of C/T/S/ sites those that are ranked 0.75 or higher by a support vector machine, within ten angstroms of the active site of the protein, and at or near a loop-?-sheet junction or a loop-?-helix junction. A method of controlling protein activity and hosts including proteins with controlled activity are also provided. Also, intein modified proteins and plants containing intein modified proteins are provided.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: April 16, 2013
    Assignee: Agrivida, Inc.
    Inventors: Binzhang Shen, Gabor Lazar, Humberto de la Vega, James Apgar, Philip Lessard, R. Michael Raab
  • Publication number: 20130036517
    Abstract: A method of predicting an intein insertion site in a protein that will lead to a switching phenotype is provided. The method includes identifying a plurality of C/T/S sites within the protein; selecting from the plurality of C/T/S/ sites those that are ranked 0.75 or higher by a support vector machine, within ten angstroms of the active site of the protein, and at or near a loop-?-sheet junction or a loop-?-helix junction. A method of controlling protein activity and hosts including proteins with controlled activity are also provided. Also, intein modified proteins and plants containing intein modified proteins are provided.
    Type: Application
    Filed: November 5, 2010
    Publication date: February 7, 2013
    Applicant: AGRIVIDA, INC.
    Inventors: James Apgar, Philip Lessard, R. Michael Raab, Binzhang Shen, Gabor Lazar, Humberto de la Vega
  • Publication number: 20130007919
    Abstract: Intein modified proteins, isolated nucleic acids encoding intein modified proteins, fragments of intein modified proteins, isolated nucleic acids encoding fragments of intein modified proteins, transgenic plants containing any of the foregoing, and antibodies recognizing epitopes on intein modified proteins are provided
    Type: Application
    Filed: November 5, 2010
    Publication date: January 3, 2013
    Applicant: AGRIVIDA, INC.
    Inventors: Binzhang Shen, Gabor Lazar, Humberto de la Vega, Philip Lessard, R. Michael Raab, James Apgar