Patents by Inventor Philip B. Komarnitsky

Philip B. Komarnitsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATMENT OF NON-SMALL-CELL LUNG CARCINOMA USING TELISOTUZUMMAB VEDOTIN AND OSIMERTINIB
    Publication number: 20230285394
    Abstract: The present disclosure provides improved methods of treatment of NSCLC cancers using the combination of telisotuzumab vedotin and osimertinib.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 14, 2023
    Inventors: Vincent Blot, Janet Yikai Jin, Philip B. Komarnitsky
  • METHODS OF TREATMENT OF NON-SMALL-CELL LUNG CARCINOMA USING TELISOTUZUMAB VEDOTIN
    Publication number: 20220323597
    Abstract: The present disclosure provides improved methods of treatment of NSCLC cancers using telisotuzumab vedotin.
    Type: Application
    Filed: April 6, 2022
    Publication date: October 13, 2022
    Inventors: Janet Yikai JIN, Philip B. KOMARNITSKY, Mirella LAZAROV, Anita REDDY
  • Organoarsenic compounds and methods for the treatment of cancer
    Patent number: 11324714
    Abstract: A method for treating a lymphoma selected from non-Hodgkin's and Hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (I) wherein X is S or Se and R1 and R2 are independently C1-30alkyl (R3, R3?, R4, R5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: May 10, 2022
    Assignee: SOLASIA PHARMA K.K.
    Inventors: Brian Eric Schwartz, Jonathan Lewis, Philip B. Komarnitsky
  • Organoarsenic compounds and methods for the treatment of cancer
    Patent number: 11324713
    Abstract: A method for treating a lymphoma selected from non-Hodgkin's and Hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (I) wherein X is S or Se and R1 and R2 are independently C1-30alkyl (R3, R3?, R4, R5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: May 10, 2022
    Assignee: SOLASIA PHARMA K.K.
    Inventors: Brian Eric Schwartz, Jonathan Lewis, Philip B. Komarnitsky
  • ORGANOARSENIC COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER
    Publication number: 20210038556
    Abstract: A method for treating a lymphoma selected from non-Hodgkin's and Hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (I) wherein X is S or Se and R1 and R2 are independently C1-30alkyl (R3, R3?, R4, R5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
    Type: Application
    Filed: October 15, 2020
    Publication date: February 11, 2021
    Applicant: SOLASIA PHARMA K.K.
    Inventors: Brian Eric Schwartz, Jonathan Lewis, Philip B. Komarnitsky
  • ORGANOARSENIC COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER
    Publication number: 20210038557
    Abstract: A method for treating a lymphoma selected from non-Hodgkin's and Hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (I) wherein X is S or Se and R1 and R2 are independently C1-30alkyl (R3, R3?, R4, R5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
    Type: Application
    Filed: October 15, 2020
    Publication date: February 11, 2021
    Applicant: SOLASIA PHARMA K.K.
    Inventors: Brian Eric Schwartz, Jonathan Lewis, Philip B. Komarnitsky
  • Organoarsenic compounds and methods for the treatment of cancer
    Patent number: 10842769
    Abstract: A method for treating a lymphoma selected from non-Hodgkin's and Hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (I) wherein X is S or Se and R1 and R2 are independently C1-30alkyl (R3, R3?, R4, R5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: November 24, 2020
    Assignee: SOLASIA PHARMA K.K.
    Inventors: Brian Eric Schwartz, Jonathan Lewis, Philip B. Komarnitsky
  • Salts of isophosphoramide mustard and analogs thereof
    Patent number: 9340563
    Abstract: Disclosed herein are crystalline compounds of formula (I) wherein A+ represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: May 17, 2016
    Assignee: ZIOPHARM Oncology, Inc.
    Inventors: John C. Amedio, Jr., Barbara Wallner, Philip B. Komarnitsky
  • ORGANOARSENIC COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER
    Publication number: 20150231107
    Abstract: A method for treating a lymphoma selected from non-Hodgkin's and Hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (I) wherein X is S or Se and R1 and R2 are independently C1-30alkyl (R3, R3?, R4, R5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
    Type: Application
    Filed: October 27, 2014
    Publication date: August 20, 2015
    Inventors: Brian Eric Schwartz, Jonathan Lewis, Philip B. Komarnitsky
  • Method for controlling angiogenesis in animals
    Patent number: 8796329
    Abstract: Organic arsenical compounds are useful to inhibit angiogenesis in a variety of disease conditions.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: August 5, 2014
    Assignee: Ziopharm Oncology, Inc.
    Inventors: Barbara P. Wallner, Philip B. Komarnitsky
  • INDIBULIN THERAPY
    Publication number: 20140193519
    Abstract: The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is synergistic. Another aspect of the invention relates to the treatment of cancer with indibulin as a single agent. Another aspect of the invention relates to dosing regimen for administration of oral dosage forms of indibulin.
    Type: Application
    Filed: August 2, 2013
    Publication date: July 10, 2014
    Applicant: ZIOPHARM ONCOLOGY, INC.
    Inventors: Barbara P. Wallner, Brian Eric Schwartz, Philip B. Komarnitsky, Gerald Bacher, Bernhard Kutscher, Gerhard Raab
  • Salts of Isophosphoramide Mustard and Analogs Thereof
    Publication number: 20140194377
    Abstract: Disclosed herein are crystalline compounds of formula (I) wherein A+ represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.
    Type: Application
    Filed: November 6, 2013
    Publication date: July 10, 2014
    Applicant: ZIOPHARM ONCOLOGY, INC.
    Inventors: John C. AMEDIO, JR., Barbara WALLNER, Philip B. KOMARNITSKY
  • Salts of isophosphoramide mustard and analogs thereof
    Patent number: 8604007
    Abstract: Disclosed herein are crystalline compounds of formula (I) wherein A+ represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: December 10, 2013
    Assignee: Ziopharm Oncology, Inc.
    Inventors: John C. Amedio, Jr., Barbara P. Wallner, Philip B. Komarnitsky
  • Combination Therapy With Organic Arsenicals
    Publication number: 20130261082
    Abstract: The invention provides a combination therapy wherein one or more other therapeutic agents are administered with an organic arsenical, preferably SGLU-I or a pharmaceutically acceptable salt thereof. The invention also relates to methods for the treatment of cancer, comprising administering SGLU-I in combination with another therapeutic agent. Another aspect of the invention relates to a kit comprising SGLU-I and another therapeutic agent.
    Type: Application
    Filed: March 6, 2013
    Publication date: October 3, 2013
    Applicant: ZIOPHARM ONCOLOGY, INC.
    Inventors: Barbara WALLNER, Philip B. KOMARNITSKY
  • Combination Therapy With Organic Arsenicals
    Publication number: 20120295861
    Abstract: The invention provides a combination therapy wherein one or more other therapeutic agents are administered with an organic arsenical, preferably SGLU-I or a pharmaceutically acceptable salt thereof. The invention also relates to methods for the treatment of cancer, comprising administering SGLU-I in combination with another therapeutic agent. Another aspect of the invention relates to a kit comprising SGLU-I and another therapeutic agent.
    Type: Application
    Filed: July 26, 2012
    Publication date: November 22, 2012
    Applicant: ZIOPHARM ONCOLOGY, INC.
    Inventors: Barbara P. WALLNER, Philip B. KOMARNITSKY
  • Combination therapy with organic arsenicals
    Patent number: 8252773
    Abstract: The invention provides a combination therapy wherein one or more other therapeutic agents are administered with an organic arsenical, preferably SGLU-1 or a pharmaceutically acceptable salt thereof. The invention also relates to methods for the treatment of cancer, comprising administering SGLU-1 in combination with another therapeutic agent. Another aspect of the invention relates to a kit comprising SGLU-1 and another therapeutic agent.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: August 28, 2012
    Assignee: Ziopharm Oncology, Inc.
    Inventors: Barbara P. Wallner, Philip B. Komarnitsky
  • ORGANOARSENIC COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER
    Publication number: 20110269697
    Abstract: A method for treating a lymphoma selected from non-Hodgkin's and Hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (I) wherein X is S or Se and R1 and R2 are independently C1-30alkyl(R3, R3?, R4, R5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
    Type: Application
    Filed: August 14, 2009
    Publication date: November 3, 2011
    Inventors: Brian Eric Schwartz, Jonathan Lewis, Philip B. Komarnitsky
  • COMBINATION THERAPY WITH ORGANIC ARSENICALS
    Publication number: 20100311689
    Abstract: The invention provides a combination therapy wherein one or more other therapeutic agents are administered with an organic arsenical, preferably SGLU-1 or a pharmaceutically acceptable salt thereof. The invention also relates to methods for the treatment of cancer, comprising administering SGLU-1 in combination with another therapeutic agent. Another aspect of the invention relates to a kit comprising SGLU-1 and another therapeutic agent.
    Type: Application
    Filed: October 31, 2008
    Publication date: December 9, 2010
    Applicant: ZIOPHARM Oncology, Inc
    Inventors: Barbara P. Wallner, Philip B. Komarnitsky
  • Salts of isophosphoramide mustard and analogs thereof
    Publication number: 20080255056
    Abstract: Disclosed herein are crystalline compounds of formula (I) wherein A+ represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 16, 2008
    Applicant: ZIOPHARM Oncology, Inc.
    Inventors: John C. Amedio, Barbara P. Wallner, Philip B. Komarnitsky
  • Indibulin therapy
    Publication number: 20080241274
    Abstract: The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is synergistic. Another aspect of the invention relates to the treatment of cancer with indibulin as a single agent. Another aspect of the invention relates to dosing regimen for administration of oral dosage forms of indibulin.
    Type: Application
    Filed: November 27, 2007
    Publication date: October 2, 2008
    Applicant: ZIOPHARM Oncology, Inc.
    Inventors: Barbara P. Wallner, Brian Eric Schwartz, Philip B. Komarnitsky, Gerald Bacher, Bernhard Kutscher, Gerhard Raab