Patents by Inventor Philip Collier

Philip Collier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 5-fluoro-1H-pyrazolo [3,4-B] pyridin-3-amine and derivatives thereof
    Patent number: 8242272
    Abstract: The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: August 14, 2012
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Juan Miguel Jimenez, Philip Collier, Andrew Miller, Jeremy Green, Huai Gao, Sylvain Loïc Jean-Luc Hamon, Albert Cornelis Dros
  • PYRAZOLOPYRIDINES
    Publication number: 20120178778
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: November 4, 2011
    Publication date: July 12, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Juan-Miguel Jimenez, Philip Collier
  • Fuel oil compositions
    Patent number: 8211190
    Abstract: This invention relates to fuel oil, especially middle distillate fuel oil, compositions comprising middle distillate fuel oil and incorporated therein an incorporated therein an additive composition comprising (a) at least one fuel-soluble or fuel-dispersible neutral alkaline earth metal compound and/or at least one fuel-soluble or fuel-dispersible neutral alkali metal compound, and (b) at least one fuel-soluble or fuel-dispersible transition metal compound, characterized in that the fuel oil composition contains at most 0.05 mass % of sulfur, the total metal content derived from (a) and (b) in the fuel oil composition is at most 50 ppm by mass, and the mass proportion of (a) to (b), based on metal content, is in the range of from 1:99 to 99:1.
    Type: Grant
    Filed: April 20, 2005
    Date of Patent: July 3, 2012
    Assignee: Infineum International Limited
    Inventors: Rinaldo Caprotti, Brid Dilworth, Carlo S. Fava, Philip Collier
  • KINASE INHIBITORS
    Publication number: 20120149680
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: October 18, 2011
    Publication date: June 14, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Juan-Miguel Jimenez, Michael Mortimore, Andrew Miller, Philip Collier, Stephen Young, Guy Brenchley, Chris Davis, Heather Twin, Chau Mak, Dean Boyall, Shazia Keily, Luca Settimo
  • Kinase inhibitors
    Patent number: 8173635
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: May 8, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Juan-Miguel Jimenez, Michael Mortimore, Andrew Miller, Philip Collier, Stephen Young, Guy Brenchley, Chris Davis, Heather Twin, Chau Mak, Dean Boyall, Shazia Keily, Luca Settimo
  • AMINOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES
    Publication number: 20110021559
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
    Type: Application
    Filed: June 2, 2010
    Publication date: January 27, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Juan-Miguel Jimenez, Philip Collier, Jeremy Green, Gregory Henkel, Michael Liu, Timothy Neuberger
  • Process for Preparing 5-Fluoro-1H-Pyrazolo [3,4-b] Pyridin-3-amine and Derivatives Thereof
    Publication number: 20100184980
    Abstract: The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
    Type: Application
    Filed: January 28, 2010
    Publication date: July 22, 2010
    Inventors: Juan-Miguel Jimenez, Philip Collier, Andrew Miller, Jeremy Green, Huai Gao, Sylvain Loïc Jean-Luc Hamon, Albert Cornelis Dros
  • AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES
    Publication number: 20100022507
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: June 17, 2009
    Publication date: January 28, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Juan-Miguel l Jimenez, Philip Collier, Andrew Miller
  • AMINOPYRIDINES AND AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES
    Publication number: 20100022502
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: May 1, 2009
    Publication date: January 28, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Juan-Miguel Jimenez, Philip Collier, Andrew Miller
  • THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES
    Publication number: 20090306155
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
    Type: Application
    Filed: August 10, 2009
    Publication date: December 10, 2009
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Juan-Miguel Jimenez, Ronald Knegtel, Daniel Robinson, Philip Collier
  • KINASE INHIBITORS
    Publication number: 20090291937
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: October 31, 2008
    Publication date: November 26, 2009
    Inventors: Juan-Miguel Jimenez, Michael Mortimore, Andrew Miller, Philip Collier, Stephen Young, Guy Brenchley, Chris Davis, Heather Twin, Chau Mak, Dean Boyall, Shazia Keily, Luca Settimo
  • Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases
    Patent number: 7589214
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: September 15, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Juan-Miguel Jimenez, Ronald Knegtel, Daniel Robinson, Philip Collier
  • Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases
    Publication number: 20070298065
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
    Type: Application
    Filed: April 11, 2007
    Publication date: December 27, 2007
    Inventors: Juan-Miguel Jimenez, Ronald Knegtel, Daniel Robinson, Philip Collier
  • Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases
    Publication number: 20070213327
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
    Type: Application
    Filed: February 12, 2007
    Publication date: September 13, 2007
    Inventors: Philip Collier, Juan-Miguel Jimenez
  • Diesel fuel additive compositions for improvement of particulate traps
    Publication number: 20060230672
    Abstract: A diesel fuel composition which improves the performance of diesel engine particulate exhaust traps comprising a diesel fuel containing a combination of 1-25 ppm of metal in the form of a metal salt additive and 100 to 500 ppm of an oil soluble nitrogen containing ashless detergent additive.
    Type: Application
    Filed: June 15, 2006
    Publication date: October 19, 2006
    Inventors: Philip Collier, Rinaldo Caprotti
  • Fuel oil compositions
    Publication number: 20050188606
    Abstract: This invention relates to fuel oil, especially middle distillate fuel oil, compositions comprising middle distillate fuel oil and incorporated therein an incorporated therein an additive composition comprising (a) at least one fuel-soluble or fuel-dispersible neutral alkaline earth metal compound and/or at least one fuel-soluble or fuel-dispersible neutral alkali metal compound, and (b) at least one fuel-soluble or fuel-dispersible transition metal compound, characterised in that the fuel oil composition contains at most 0.05 mass % of sulfur, the total metal content derived from (a) and (b) in the fuel oil composition is at most 50 ppm by mass, and the mass proportion of (a) to (b), based on metal content, is in the range of from 1:99 to 99:1.
    Type: Application
    Filed: April 20, 2005
    Publication date: September 1, 2005
    Inventors: Rinaldo Caprotti, Brid Dilworth, Carlo Fava, Philip Collier
  • Strike plate construction for sliding glass door or window lock
    Patent number: 3976317
    Abstract: A vertically elongated metal strike plate is mounted on the lock jamb of a sliding glass door or window by a pair of screws disposed on a substantially horizontal central plane through a vertically elongated strike plate aperture. The strike plate is vertically positioned so that when the door or window is slid into closed position and the lock stile is moved into abutment with the jamb, the latch hook projects through the registering central aperture. Then, when the latch is elevated by actuation of the locking lever the hook interferes with the upper back surface of the strike plate and prevents separation of the lock stile and the jamb.
    Type: Grant
    Filed: January 2, 1976
    Date of Patent: August 24, 1976
    Assignee: Blomberg Glass
    Inventor: John Philip Collier