Abstract: A fastening assembly suitable for being fastened to a substrate with a front face and a first hole. The fastening assembly includes a fastening plate with a second plate with front and rear faces and pierced with a second hole aligned with the first hole. The fastening plate front face is fastened to the substrate rear face. The assembly includes a nut holder with a third plate with front and rear faces and pierced with a third hole aligned with the second hole and a nut fastened to the third plate on the side of the rear face and coaxial with the third hole. The front face of the nut holder is fastened to the rear face of the fastening plate. The fastening plate includes a first fastener that engages with a second fastener of the nut holder to removably fasten the nut holder to the fastening plate.

Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.

Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.

Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.

Abstract: A fastening assembly suitable for being fastened to a substrate with a front face and a first hole. The fastening assembly includes a fastening plate with a second plate with front and rear faces and pierced with a second hole aligned with the first hole. The fastening plate front face is fastened to the substrate rear face. The assembly includes a nut holder with a third plate with front and rear faces and pierced with a third hole aligned with the second hole and a nut fastened to the third plate on the side of the rear face and coaxial with the third hole. The front face of the nut holder is fastened to the rear face of the fastening plate. The fastening plate includes a first fastener that engages with a second fastener of the nut holder to removably fasten the nut holder to the fastening plate.

Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (h) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.

Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.

Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.

Abstract: Described herein is a composition comprising: (a) a first population of particles of a first aripiprazole prodrug; and (b) a second population of particles of a second aripiprazole prodrug, different to the first aripiprazole prodrug. At least one of the first and second prodrug populations has a volume based particle size (Dv50) of less than about 1000 nm. Also described herein are methods of treatment using the aforementioned composition, and methods of making the aforementioned composition.

Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.

Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilization of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.

Abstract: Described herein is a composition comprising: (a) a first population of particles of a first aripiprazole prodrug; and (b) a second population of particles of a second aripiprazole prodrug, different to the first aripiprazole prodrug. At least one of the first and second prodrug populations has a volume based particle size (Dv50) of less than about 1000 nm. Also described herein are methods of treatment using the aforementioned composition, and methods of making the aforementioned composition.

Abstract: A fastener system (9) for fastening a first structure to a second structure, the fastener system (9) includes: (i) a bolt (11) having a countersink bolt head (15), a bolt tip (17), and a threaded male portion (19) extending from the countersink bolt head (15) towards the bolt tip (17), (ii) a nut (13) having a countersink nut head (23), a nut tip (25) and a female shank portion (27) extending from the countersink nut head (23) towards the nut tip (25), wherein the female shank portion (27) includes an inner thread (29) configured for co-operating with the threaded male portion (19) of the bolt (11), and (iii) at least one cavity (33, 35) for a locking material, the at least one cavity (33, 35) is formed in the threaded male portion (19) of the bolt (11) and/or the inner thread of the female shank portion (27) of the nut (13).

Abstract: Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.

Abstract: An assembly comprising at least two non-metal components which are fixed to each other using at least one fixing system. The fixing system includes a fixing device with a fixing element which is provided with a head and a rod, and a crimping ring which is in contact with one of the components. A protection device is a part of the fixing system which delimits a cavity for confining gas around a portion of the device comprising the crimping ring. In order to improve the repeatability of the operation for positioning the protection device, a guiding device is provided which includes an assembly element on the portion of the fixing device, and an element for guiding the protection device.

Abstract: An assembly comprising at least two non-metal components which are fixed to each other using at least one fixing system. The fixing system includes a fixing device with a fixing element which is provided with a head and a rod, and a crimping ring which is in contact with one of the components. A protection device is a part of the fixing system which delimits a cavity for confining gas around a portion of the device comprising the crimping ring. In order to improve the repeatability of the operation for positioning the protection device, a guiding device is provided which includes an assembly element on the portion of the fixing device, and an element for guiding the protection device.