Patents by Inventor Philip H. Coelho
Philip H. Coelho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150321203Abstract: The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.Type: ApplicationFiled: July 7, 2015Publication date: November 12, 2015Inventors: John Raymond Chapman, Rodney D. Sparks, Philip H. Coelho
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Patent number: 9101925Abstract: The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.Type: GrantFiled: August 19, 2011Date of Patent: August 11, 2015Assignee: MicroAire Surgical Instruments, LLCInventors: John R. Chapman, Rodney Sparks, Philip H. Coelho
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Patent number: 9101926Abstract: The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.Type: GrantFiled: August 19, 2011Date of Patent: August 11, 2015Assignee: MicroAire Surgical Instruments, LLCInventors: John R. Chapman, Rodney Sparks, Philip H. Coelho
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Patent number: 9050422Abstract: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.Type: GrantFiled: March 15, 2012Date of Patent: June 9, 2015Assignee: Cesca TherapeuticsInventors: Philip H. Coelho, Bruce A. Baker, John R. Chapman, Junzhi Li, Prince Emmanuel, Robert S. Childers
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Publication number: 20140212914Abstract: A method for purifying and harvesting certain cell populations in blood or bone marrow by depleting at least one of red blood cells, granulocytes, or platelets from a sample comprising blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue is disclosed. The apparatus comprises a sterile, single use rigid, self-supporting cartridge within which the automated depletion, purification and harvesting of target cell populations occurs and all components may be distributed.Type: ApplicationFiled: April 19, 2014Publication date: July 31, 2014Applicant: SYNGEN INC.Inventor: Philip H. Coelho
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Publication number: 20140212912Abstract: A purified solution of human plasma, MNCs and platelets isolated from whole blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue wherein said purified solution comprises at least 90% by number of the MNCs in said whole blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue, said purified solution comprises at most 10% by number of the red blood cells and granulocytes in said whole blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue, and said purified solution is isolated and separated from said whole blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue during a single centrifugation run.Type: ApplicationFiled: April 19, 2014Publication date: July 31, 2014Applicant: SynGen Inc.Inventor: Philip H. Coelho
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Patent number: 8747289Abstract: An apparatus and method for purifying and harvesting certain cell populations in blood or bone marrow by depleting at least one of red blood cells, granulocytes, or platelets from a sample comprising blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue is disclosed. The apparatus comprises a sterile, single use rigid, self-supporting cartridge within which the automated depletion, purification and harvesting of target cell populations occurs and all components may be distributed.Type: GrantFiled: March 17, 2011Date of Patent: June 10, 2014Assignee: SynGen Inc.Inventor: Philip H. Coelho
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Publication number: 20130029370Abstract: An apparatus and method for purifying and harvesting certain cell populations in blood or bone marrow by depleting at least one of red blood cells, granulocytes, or platelets from a sample comprising blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue is disclosed. The apparatus comprises a sterile, single use rigid, self-supporting cartridge within which the automated depletion, purification and harvesting of target cell populations occurs and all components may be distributed.Type: ApplicationFiled: March 17, 2011Publication date: January 31, 2013Applicant: SYNGEN INC.Inventor: Philip H. Coelho
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Publication number: 20120171762Abstract: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.Type: ApplicationFiled: March 15, 2012Publication date: July 5, 2012Inventors: Philip H. Coelho, Bruce A. Baker, John R. Chapman, Junzhi Li, Prince Emmanuel, Robert S. Childers
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Patent number: 8167139Abstract: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.Type: GrantFiled: July 6, 2007Date of Patent: May 1, 2012Assignee: ThermoGenesis Corp.Inventors: Philip H. Coelho, Bruce A. Baker, John R. Chapman, Junzhi Li, Prince Emmanuel, Robert S. Childers
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Publication number: 20120065048Abstract: The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.Type: ApplicationFiled: August 19, 2011Publication date: March 15, 2012Inventors: John R. Chapman, Rodney Sparks, Philip H. Coelho
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Publication number: 20120065047Abstract: The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.Type: ApplicationFiled: August 19, 2011Publication date: March 15, 2012Inventors: John R. Chapman, Rodney Sparks, Philip H. Coelho
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Patent number: 8066127Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. The sensor may be reading one or more of the following characteristics: infrared, optics, density, weight, radioactive, fluorescence, color, magnetism, ultrasonic, capacitance wherein the characteristic is inherent in the blood and blood component or is an additive. Each component may then be separated into its own storage container. The preferred sensors include optics and weight.Type: GrantFiled: August 16, 2005Date of Patent: November 29, 2011Assignee: ThermoGenesis Corp.Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs, Bruce Baker, Brian Malone
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Publication number: 20080311651Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. The sensor may be reading one or more of the following characteristics: infrared, optics, density, weight, radioactive, fluorescence, color, magnetism, ultrasonic, capacitance wherein the characteristic is inherent in the blood and blood component or is an additive. Each component may then be separated into its own storage container. The preferred sensors include optics and weight.Type: ApplicationFiled: August 16, 2005Publication date: December 18, 2008Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs, Bruce Baker, Brian Malone
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Patent number: 7241281Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.Type: GrantFiled: April 8, 2002Date of Patent: July 10, 2007Assignee: ThermoGenesis CorporationInventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs
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Patent number: 7211191Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.Type: GrantFiled: September 30, 2004Date of Patent: May 1, 2007Assignee: ThermoGenesis Corp.Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs
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Publication number: 20040254560Abstract: A rupture resistant medical product freezer bag and method formed by blow molding.Type: ApplicationFiled: June 11, 2003Publication date: December 16, 2004Inventors: Philip H. Coelho, Phillip Kingsley
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Publication number: 20030191005Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.Type: ApplicationFiled: April 8, 2002Publication date: October 9, 2003Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs, Pablo Rubinstein
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Patent number: 6302327Abstract: A system and method for controlled rate freezing and storage of thermolabile substances. The system includes a storage unit for receiving product stored within a bag and an overlying protective canister associated with a robotic arm and reading device which places the canister in the preserving environment. A control system, driven by a computer monitors the ingress, egress and storage location and particularized profiles of the articles being placed in storage.Type: GrantFiled: June 16, 1997Date of Patent: October 16, 2001Assignee: ThermoGenesis, Corp.Inventors: Philip H. Coelho, Pablo Rubinstein, Mark Buckley, Kevin Pelletier
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Patent number: 6213334Abstract: A flexible, three-dimensional container is made by a prescribed vacuum-molding and heat sealing process. The container possesses a precise, defined geometry before and during use. The container is formed from first and second walls. The first wall has a planar area and a vacuum-molded cavity area drawn out of the plane of the planar area into a predefined three-dimensional geometry. A second wall overlies the first wall to close the cavity area and thereby forms an interior compartment. A thermal seal joins the two walls together. The seal is formed by heating the second wall and the first wall in the planar area, while assuring that the cavity area of the first wall is not subject to heating and possible deformation of its precise vacuum-molded geometry.Type: GrantFiled: September 5, 1996Date of Patent: April 10, 2001Assignee: Baxter International INCInventors: Philip H. Coelho, Ludwig Wolf, Jr., David P. Fisher, Allen R. Wons, William Bratten