Abstract: Diverse types of crew interfaces (400, 430, 450) are provided for outputting visible, audio and tactile information to a pilot for flight control. A unified estimation of the current aircraft state and of a current phase of flight are made (110), based on flight status information. Respective coordinated visible, audio and tactile presentations for the diverse types of crew interfaces are generated, (120) coordinated so that they provide mutually consistent indications of the unified estimation of the current aircraft state, according to the unified estimation of current flight phase. The respective coordinated presentations are output (130) by the diverse types of crew interfaces to the pilot. By coordinating crew interface outputs across sight, sound and touch senses, this can relieve the pilot of workload in interpreting unsynchronised or incoherent outputs from different types of interfaces.

Abstract: The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a cellular system being capable of expressing at least a panel of 11 defined genes, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the genes in the system with the gene expression in a control cellular system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring physiological and/or pathological conditions, which are caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, by administering an effective amount of at least a single (pro-)genotoxic compound to a mammal in need of such treatment and determining an expression of 11 defined genes in a biological sample withdrawn from the mammal.

Abstract: A communications system and method, for facilitating exchange of data between a first computer and a second computer connected in a network to operate in a client/server arrangement: The first computer employing a different operating system to the second computer and the system having a basic communications application program interface (API). The system includes a first device for processing requests from a first application running on the first computer for connection with the second computer to carry out one of a plurality of communication services, second device for instructing a second application on the second computer to carry out the communications services and for returning data provided by the second application to the first computer and a storage device, on each computer accessible by the respective devices, storing a single object class for providing definitions for each of the plurality of communication services.