Abstract: A disposable set of components for an organ perfusion system comprising a fluid supply duct for supplying fluid to the organ, a fluid removal duct for removing fluid from the organ, and a surrogate organ removably connected between the fluid supply duct and the fluid removal duct so as to form a fluid circuit, so that fluid can be circulated in the circuit in preparation for connection of the organ.

Abstract: A dispensing closure, in accordance with one aspect of the present disclosure, includes a closure shell of plastic construction having a skirt for mounting on a container neck finish. An insert of plastic construction different from and more rigid than the shell includes a mid portion mounted to the shell, a base with the skirt for sealing engagement with a container neck finish when the closure is mounted on the neck finish, a tip extending from the mid portion and a through-passage for dispensing product from within the container. An overcap is provided for removable receipt over the tip, and preferably is of one-piece integrally molded construction with the shell and flexibly tethered to the shell. The base of the insert preferably is constructed for sealing engagement with the inside surface of the container neck finish, the end surface of the container neck finish and/or the outside edge of the container neck finish.