Patents by Inventor Philip K. Ahring

Philip K. Ahring has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
    Patent number: 8946412
    Abstract: This invention relates to diazabicyclononyl oxadiazolyl derivatives, which are found to-be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Ar1 represents a pyrrolyl group, optionally substituted with alkyl or halo-alkyl.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: February 3, 2015
    Assignee: Danpet AB
    Inventors: Dan Peters, Daniel B. Timmermann, Elsebet Østergaard Nielsen, Tino Dyhring, Philip K. Ahring
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 8492408
    Abstract: The present application discloses novel benzimidazole derivatives and their use as modulators of the GABAA receptor complex. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: July 23, 2013
    Assignee: Aniona APS
    Inventors: Janus S. Larsen, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • DIAZABICYCLONONYL OXADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
    Publication number: 20130004428
    Abstract: This invention relates to diazabicyclononyl oxadiazolyl derivatives, which are found to-be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Ar1 represents a pyrrolyl group, optionally substituted with alkyl or halo-alkyl.
    Type: Application
    Filed: December 16, 2010
    Publication date: January 3, 2013
    Applicant: NEUROSEARCH A/S
    Inventors: Dan Peters, Daniel B. Timmermann, Elsebet Østergaard Nielsen, Tino Dyhring, Philip K. Ahring
  • TETRAZOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
    Publication number: 20120309792
    Abstract: This invention relates to novel tetrazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: December 16, 2010
    Publication date: December 6, 2012
    Applicant: NEUROSEARCH A/S
    Inventors: Dan Peters, Morten Grunnet, Daniel B. Timmermann, Birgitte L. Eriksen, Tino Dyhring, Philip K. Ahring
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 8288418
    Abstract: Benzimidazole derivatives, pharmaceutical compositions containing them, and methods of treatment therewith involving modulation of the GABAA receptor complex. The compounds have the formula I: wherein the variables are as described in the specification. The compounds are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: October 16, 2012
    Assignee: Neurosearch A/S
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • NOVEL OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20110263577
    Abstract: This invention relates to novel oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: October 8, 2009
    Publication date: October 27, 2011
    Applicant: NEUROSEARCH A/S
    Inventors: Dan Peters, Daniel B. Timmermann, Gunnar M. Olsen, Elsebet Østergaard Nielsen, Philip K. Ahring, Tino Dyhring, Jeppe Kejser Christensen
  • BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
    Publication number: 20110257230
    Abstract: The present application discloses novel benzimidazole derivatives and their use as modulators of the GABAA receptor complex. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: November 13, 2009
    Publication date: October 20, 2011
    Applicant: NEUROSEARCH A/S
    Inventors: Janus S. Larsen, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
    Publication number: 20110257210
    Abstract: The present application discloses novel benzimidazole derivatives of general formula (I) or an N-oxide thereof, any of its stereoisomers or any mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein R represents a pyridyl or pyrimidyl group; which pyridyl or pyrimidyl group is optionally substituted with one or more substituents independently selected from the group consisting of: halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, alkyl, hydroxy, hydroxyalkyl and alkoxy, and their use as modulators of the GABAA receptor complex. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: November 13, 2009
    Publication date: October 20, 2011
    Applicant: NEUROSEARCH A/S
    Inventors: Janus S. Larsen, Philip K. Ahring, Elsebet ?stergaard Nielsen, Naheed Mirza
  • Imidazole derivatives for the treatment of anxiety and related diseases
    Patent number: 8030339
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: October 4, 2011
    Assignee: Neurosearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Østergaard Nielsen
  • NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
    Publication number: 20110118268
    Abstract: This invention relates to novel 1,4-diaza-bicyclo[3.2.1]octane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: March 9, 2009
    Publication date: May 19, 2011
    Inventors: Dan Peters, Daniel B. Timmermann, Elsebet Østergaard Nielsen, Gunnar M. Olsen, Tino Dyhring, Jeppe Kejser Christensen, Philip K. Ahring, John Paul Redrobe
  • BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
    Publication number: 20110118259
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: January 20, 2011
    Publication date: May 19, 2011
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Ostergaard Nielsen, Naheed Mirza
  • AZABICYCLOOCTYL-QUINAZOLONE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
    Publication number: 20110112119
    Abstract: This invention relates to novel azabicyclooctyl-quinazolinone derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: June 9, 2009
    Publication date: May 12, 2011
    Applicant: NEUROSEARCH A/S
    Inventors: Dan Peters, Daniel B. Timmermann, Elsebet Østergaard Nielsen, Gunnar M. Olsen, Tino Dyhring, Jeppe Kejser Christensen, Philip K. Ahring, John Paul Redrobe, Jens Damsgaard Mikkelsen
  • NOVEL OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20110112078
    Abstract: This invention relates to novel oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholin receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: June 9, 2009
    Publication date: May 12, 2011
    Applicant: NEUROSEARCH A/S
    Inventors: Dan Peters, Daniel B. Timmermann, Elsebet Ostergaard Nielsen, Gunnar M. Olsen, Philip K. Ahring, Tino Dyhring, Jeppe Kejser Christensen, John Paul Redrobe, Jens Damsgaard Mikkelsen
  • Imidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7939556
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: May 10, 2011
    Assignee: Neurosearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Østergaard Nielsen
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7923464
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: April 12, 2011
    Assignee: Neurosearch A/S
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7902230
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: March 8, 2011
    Assignee: Neurosearch A/S
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • Imidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7858649
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are of the general formula (I) and include any of its stereoisomers, any mixture of its stereoisomers, and pharmaceutically acceptable salts thereof. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: December 28, 2010
    Assignee: Neurosearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Østergaard Nielsen
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7851490
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: December 14, 2010
    Assignee: Neurosearch A/S
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7776900
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: August 17, 2010
    Assignee: Neurosearch A/S
    Inventors: Lene Teuber, Janus S. Larsen, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • PYRROLO [3, 4-h] ISOQUINOLINE COMPOUNDS AND METHODS FOR MODULATING GATED ION CHANNELS
    Publication number: 20100197721
    Abstract: The present invention relates to compositions and methods to modulate the activity of gated ion channels.
    Type: Application
    Filed: April 12, 2010
    Publication date: August 5, 2010
    Applicant: AROS PHARMA APS
    Inventors: Rahul VOHRA, Joachim DEMNITZ, Philip K. AHRING, Zhonghong GAN, Nachhattarpal GILL