Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.

Abstract: The disclosure generally provides antibodies and antigen binding fragments of antibodies that bind ticagrelor and metabolites of ticagrelor. The disclosure also provides compositions comprising the antibodies, nucleic acid molecules encoding the antibodies, methods of treating a patient comprising administering the antibodies, and methods of making and using the antibodies.

Abstract: The present invention relates to a method of monitoring a fluid carrying conduit, comprising interrogating an optic fiber positioned along the path of the conduit to provide distributed acoustic sensing, measuring by distributed acoustic sensing the acoustic signal at each of a plurality of discrete longitudinal sensing portions along the length of the optic fiber, to monitor the optic fiber for the presence of a first characteristic signal, the first characteristic signal being indicative of ground heave the vicinity of the optic fiber, and determining that a failure has occurred in the conduit when a first characteristic signal is measured in the distributed acoustic sensing.

Abstract: A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.

Abstract: The disclosure generally provides antibodies and antigen binding fragments of antibodies that bind ticagrelor and metabolites of ticagrelor. The disclosure also provides compositions comprising the antibodies, nucleic acid molecules encoding the antibodies, methods of treating a patient comprising administering the antibodies, and methods of making and using the antibodies.

Abstract: A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.

Abstract: The present invention provides human, humanized and/or chimeric antibodies as well as fragments, derivatives/conjugates and compositions thereof with a specific binding affinity for interleukin-18. The invention includes the use of these antibodies for diagnosing and treating diseases associated with increased IL-18 activity, the latter in the form of a pharmaceutical composition.

Abstract: The present invention provides human, humanized and/or chimeric antibodies as well as fragments, derivatives/conjugates and compositions thereof with a specific binding affinity for interleukin-18. The invention includes the use of these antibodies for diagnosing and treating diseases associated with increased IL-18 activity, the latter in the form of a pharmaceutical composition.

Abstract: The present invention relates to a method of monitoring a fluid carrying conduit, comprising interrogating an optic fibre positioned along the path of said conduit to provide distributed acoustic sensing, measuring by distributed acoustic sensing the acoustic signal at each of a plurality of discrete longitudinal sensing portions along the length of the optic fibre, to monitor the optic fibre for the presence of a first characteristic signal, the first characteristic signal being indicative of ground heave the vicinity of the optic fibre, and determining that a failure has occurred in said conduit when a first characteristic signal is measured in the distributed acoustic sensing.

Abstract: A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.

Abstract: Provided are anti-PAI-1 antibodies or antibody fragments and methods of using them.

Abstract: A method and apparatus for performing remote data replication. The method and apparatus can detect an interruption in the remote data replication process and begin local logging of all local data writes that occur while the remote data replication process is unavailable. The method and apparatus can perform remote data replication across multiple remote storage devices or the method and apparatus can replicate a data structure from a first storage device to multiple locations on one or more remote storage devices. In addition, the method and apparatus can halt the remote data replication and copy data from the local storage device to the remote storage device to ensure data uniformity on all storage devices.

Abstract: User devices like disc players or set top boxes may lack a storage unit. A method of providing virtual local data storage for a user device that is connectable to a remote server (14) via a network (12) is described. A storage application (32) is provided in the user device, which initiates a socket connection to the remote server. The application provides an application interface API (35) for requests for storing auxiliary data (33) from (other) applications (31) in the user device. When a storage request is received via the API, the auxiliary data is stored on the remote server via the network (12). The new storage application may be build in a user device or memory extension, or may be provided as a downloadable plug-in or via a optical disc (CD, DVD or BD).

Abstract: There is provided a communication network (10) operable to search for programme content. The network (10) is distinguished in that it comprises: (a) a plurality of mutually interconnected network nodes (100, 110) susceptible to storing programme data content and at least one of electronic programme guides (EPG) and associated meta-data thereat; (b) at least one user-operable node (20) coupled to the network (10), the at least one user-operable node (20) including user-interfacing means (30, 50) for receiving instructions from a user (60) and presenting results to the user (60).

Abstract: The present invention relates to a method of restricting access to cookie information stored on a client, said client being communicatively connected to servers via a public communication network, wherein the client receives first party data from said server, said first party data comprising embedded links to third party web pages, where at least one of said web pages is adapted for storing client specific cookie information relating to said third party web page on said client, the method comprises the step of: restricting access to said stored cookie information, whereby only third party web pages have access to said cookie information if the third party web pages are accessed via a link from said first party data.

Abstract: A method of recording an MPEG compliant transport stream selected by a user on a storage media. The method comprising: receiving the transport stream, the transport stream comprising transport stream packets; removing stuffing bytes from each transport stream packet in the transport stream containing stuffing bytes; recording all transport stream packets on the storage media; and recording an entry in a program information file on the storage media indicating that stuffing bytes were removed from the transport stream.

Abstract: An optical disk, optical disk player and optical disk playing method are disclosed, wherein the optical disk is used to play in coordination with the downloaded contents. The optical disk has a public key used to verify whether the downloaded content is authenticated. The optical disk player comprises a reading-out means, a network interface and a verifying module, in which the reading-out means is used to read-out the content and the public key of the optical disk; the network interface is used to receive the downloaded content; and the verifying module is used to verify whether the downloaded content is authenticated according to the public key read-out from the optical disk. The optical disk playing method consists of reading-out the content and the public key of the optical disk, downloading the content, then verifying the downloaded content according to the public key read-out from the optical disk, in order to confirm whether the downloaded content is authenticated.

Abstract: A method is proposed for selectively creating a backup of electronic content information on a home network. The method determines a relative importance of the content information; and stores the backup under control of the relative importance determined.

Abstract: An optical disc player includes a detecting module and a creating module. The detecting module is used to detect whether to meet a branch point or an interruption point or a pause point; and the creating module is used to create a corresponding bookmark as a navigation for the subsequent broadcast to record the relevant information of a branch point or an interruption point or a pause point when meeting the branch point or the interruption point or the pause point. The playing method of the player includes: detecting whether to meet a branch point or an interruption point or a pause point, creating a corresponding bookmark as a navigation for the subsequent broadcast to record the relevant information of the branch point or the interruption point or the pause point when to meet the branch point or the interruption point or the pause point.

Abstract: A device is equipped with local storage arrangement such as HDD and a removable optical storage carrier input device. Removable carriers include storage applications that necessitate storage space for storing data items. A storage management unit allocates storage space of the local storage arrangement to the inserted removable optical storage carrier and the application stored therein. The management unit also attributes to the portion identification information respecting access rights granted to the application with respect to data items stored in the allocated portion. The application is given no access to data items stored outside the allocated portion.