Patents by Inventor Philip Paik
Philip Paik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9139865Abstract: Aspects of embodiments of the invention relate to a simulator including a visual display capable of outputting to a user a display one or more effects of a command series selected and a system including a droplet microactuator electronically coupled to and controlled by a processor capable of executing instructions, the droplet microactuator including a substrate comprising electrodes for conducting droplet operations. Further aspects of embodiments of the invention relate to a droplet operations troubleshooting apparatus. Other aspects of embodiments of the invention relate to a computer implemented method of displaying simulated microactuator droplets.Type: GrantFiled: November 19, 2012Date of Patent: September 22, 2015Assignees: ADVANCED LIQUID LOGIC, INC., DUKE UNIVERSITYInventors: Michael G. Pollack, Philip Paik, Vamsee K. Pamula
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Patent number: 8951732Abstract: A method of amplifying a nucleic acid, the method comprising cycling an amplification-ready droplet through a temperature gradient to locations within the temperature gradient suitable for effecting steps in an amplification reaction.Type: GrantFiled: June 23, 2008Date of Patent: February 10, 2015Assignee: Advanced Liquid Logic, Inc.Inventors: Michael G. Pollack, Vamsee K. Pamula, Philip Paik, Allen Eckhardt
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Publication number: 20130233712Abstract: A method of manipulating a droplet comprising providing a substrate comprising a surface; an elongated transport electrode disposed on the substrate surface, the elongated transport electrode having a first and a second end and configured to impart a gradient force to the droplet; and one or more wires for providing power to the transport electrode; and providing power to the one or more wires to effect the gradient force and thereby transport the droplet along the length of the elongated transport electrode from the first end to the second end.Type: ApplicationFiled: April 25, 2013Publication date: September 12, 2013Applicant: Advanced Liquid Logic Inc.Inventors: Vamsee K. Pamula, Michael G. Pollack, Vijay Srinivasan, Philip Paik
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Patent number: 8460528Abstract: On-board reagent storage, handling, and dispensing apparatuses and methods for droplet actuator systems are provided. In one embodiment, a fluidic analyzer is provided and includes a droplet actuator including a substrate including a plurality of electrodes configured to actuate a droplet and a reagent storage component in selective fluid communication with the droplet actuator and including a reagent configured to combine with a solvent at a time of use. In another embodiment, a method of conducting fluidic analysis is provided and includes storing a reagent within a reagent storage component in fluid communication with a droplet actuator including a plurality of electrodes configured to actuate a droplet and combining the reagent with a solvent at a time for use within the droplet actuator.Type: GrantFiled: October 14, 2008Date of Patent: June 11, 2013Assignee: Advanced Liquid Logic Inc.Inventors: Michael G. Pollack, Alexander Shenderov, Philip Paik, Vijay Srinivasan, Vamsee K. Pamula
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Patent number: 8041463Abstract: A droplet actuator drive including a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the detection apparatus; a droplet actuator cartridge connector arranged so that when a droplet actuator cartridge electronically is coupled thereto: the droplet actuator cartridge is aligned with the detection apparatus; and the detection apparatus can sense the property of the droplet on a droplet actuator; circuitry for controlling a droplet actuator coupled to the droplet actuator connector; and the droplet actuator circuitry may be coupled to a processor.Type: GrantFiled: February 17, 2010Date of Patent: October 18, 2011Assignees: Advanced Liquid Logic, Inc., Duke UniversityInventors: Michael G. Pollack, Philip Paik
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Publication number: 20110086377Abstract: A droplet actuator comprising: (a) a base substrate comprising electrodes configured for conducting droplet operations on a droplet operations surface thereof; (b) a droplet comprising one or more beads situated on the droplet operations surface; (c) a barrier arranged in relation to the droplet and the electrodes such that a droplet may be transported away from the beads using one or more droplet operations mediated by one or more of the electrodes while transport of the beads is restrained by a barrier. Related methods and kits are also provided.Type: ApplicationFiled: August 25, 2008Publication date: April 14, 2011Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Prasanna Thwar, Dwayne Allen, Philip Paik
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Publication number: 20100323405Abstract: A method of amplifying a nucleic acid, the method comprising cycling an amplification-ready droplet through a temperature gradient to locations within the temperature gradient suitable for effecting steps in an amplification reaction.Type: ApplicationFiled: June 23, 2008Publication date: December 23, 2010Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Michael G. Pollack, Vamsee K. Pamula, Philip Paik, Allen Eckhardt
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Publication number: 20100282609Abstract: On-board reagent storage, handling, and dispensing apparatuses and methods for droplet actuator systems are provided. In one embodiment, a fluidic analyzer is provided and includes a droplet actuator including a substrate including a plurality of electrodes configured to actuate a droplet and a reagent storage component in selective fluid communication with the droplet actuator and including a reagent configured to combine with a solvent at a time of use. In another embodiment, a method of conducting fluidic analysis is provided and includes storing a reagent within a reagent storage component in fluid communication with a droplet actuator including a plurality of electrodes configured to actuate a droplet and combining the reagent with a solvent at a time for use within the droplet actuator.Type: ApplicationFiled: October 14, 2008Publication date: November 11, 2010Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Michael G. Pollack, Alexander Shenderov, Philip Paik, Vijay Srinivasan, Vamsee K. Pamula
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Publication number: 20100270156Abstract: A droplet actuator with a droplet formation electrode configuration associated with a droplet operations surface, wherein the electrode configuration comprises one or more electrodes configured to control volume of a droplet during formation of a sub-droplet on the droplet operations surface. Methods of making and using the droplet actuator are also provided.Type: ApplicationFiled: December 23, 2008Publication date: October 28, 2010Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Vijay Srinivasan, Michael G. Pollack, Vamsee K. Pamula, Zhishan Hua, Arjun Sudarsan, Philip Paik
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Publication number: 20100143963Abstract: The invention provides a droplet actuator drive. In certain embodiments, the droplet actuator drive may include a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the detection apparatus; a droplet actuator cartridge connector; circuitry for controlling a droplet actuator coupled to the droplet actuator connector; and/or a means for coupling the droplet actuator circuitry to a processor. Systems, kits and methods of conducting assays are also provided.Type: ApplicationFiled: February 17, 2010Publication date: June 10, 2010Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Michael G. Pollack, Philip Paik
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Publication number: 20100025250Abstract: The objective of this research is to model and design a microfluidic system that uses electrostatic fields to induce movement of discrete droplets of solution. Of particular interest is movement of droplets of H2O for use in biological testing with lab-on a-chip and ?TAS systems. Using computer modeling, the electric-fields for planar electrode configurations positioned on an insulating substrate are calculated for a hemispherical drop of H2O on the substrate at various positions. From these electric-fields the force on the drop is calculated. These models show that electrostatic actuation of droplets of H2O is possible. However, as the complexity of the model increases the properties of the system become less desirable and actuation may not be possible. Using microfabrication techniques, the modeled microfluidic systems have been built for testing using a Kapton substrate with copper electrodes.Type: ApplicationFiled: March 3, 2008Publication date: February 4, 2010Applicant: ADVANCED LIQUID LOGIC, INC.Inventors: Vamsee K. Pamula, Michael G. Pollack, Vijay Srinivasan, Philip Paik
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Publication number: 20080105549Abstract: Methods for sampling a liquid flow are provided. The method includes supplying a continuous liquid flow from a continuous flow fluid input source to a surface along a first flow path. The method additionally includes sampling the continuous liquid flow by performing an electric field-based technique to split off a sample droplet from a portion of the liquid flow, whereby the sample droplet is distinct from the liquid flow and controllable independently of the liquid flow, wherein the electric field-based technique is performed by providing a set of electrodes on the surface and selectively biasing the set of electrodes, whereby the sample droplet is formed on one of the set of electrodes.Type: ApplicationFiled: November 7, 2007Publication date: May 8, 2008Inventors: Vamsee Pamela, Michael Pollack, Philip Paik, Hong Ren, Richard Fair
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Publication number: 20080038810Abstract: The present invention relates to a droplet-based nucleic acid amplification device, system, and method. According to one embodiment, a droplet microactuator is provided and includes: (a) a substrate comprising electrodes for conducting droplet operations; and (b) one or more temperature control means arranged in proximity with one or more of the electrodes for heating and/or cooling a region of the droplet microactuator and arranged such that a droplet can be transported on the electrodes into the region for heating.Type: ApplicationFiled: December 15, 2006Publication date: February 14, 2008Inventors: Michael Pollack, Philip Paik, Vamsee Pamula
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Publication number: 20080006535Abstract: Systems for controlling a droplet microactuator are provided. According to one embodiment, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, and a display device displaying a user interface electronically coupled to the controller, wherein the system is programmed and configured to permit a user to effect a droplet manipulation by interacting with the user interface. According to another embodiment, a system is provided and includes a processor, a display device electronically coupled to the processor, and software loaded and/or stored in a storage device electronically coupled to the controller, a memory device electronically coupled to the controller, and/or the controller and programmed to display an interactive map of a droplet microactuator.Type: ApplicationFiled: August 14, 2007Publication date: January 10, 2008Inventors: Philip Paik, Michael Pollack, Ryan Sturmer, Gregory Smith, Keith Brafford, Vamsee Pamula
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Publication number: 20060054503Abstract: Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.Type: ApplicationFiled: March 10, 2005Publication date: March 16, 2006Inventors: Vamsee Pamula, Michael Pollack, Philip Paik, Hong Ren, Richard Fair