Patents by Inventor Philip Ralph Dormitzer
Philip Ralph Dormitzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240100153Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least two introduced amino acid mutations relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.Type: ApplicationFiled: November 10, 2023Publication date: March 28, 2024Inventors: Yuhang Liu, Ye Che, Xiaoyuan Sherry Chi, Philip Ralph Dormitzer, Jennifer Anne Nicki, Xiaojie Yao
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Patent number: 11857622Abstract: The present invention comprises mutants of a wild-type cytomegalovirus (CMV) glycoprotein B (gB) protein that include at least two introduced amino acid mutations relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB), compositions including the mutants and uses thereof. In some embodiments, the mutant is stabilized in a conformation alternative to the gB postfusion conformation.Type: GrantFiled: June 17, 2021Date of Patent: January 2, 2024Assignee: Pfizer Inc.Inventors: Yuhang Liu, Ye Che, Xiaoyuan Sherry Chi, Philip Ralph Dormitzer, Jennifer Anne Nicki, Xiaojie Yao
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Publication number: 20230233671Abstract: The present disclosure relates to RNA molecules encoding a varicella zoster virus (VZV). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the treatment or prevention of herpes zoster or shingles.Type: ApplicationFiled: October 12, 2022Publication date: July 27, 2023Inventors: Eric Matthew Bennett, Fernando Martin Diaz, Philip Ralph Dormitzer, Kathrin Ute Jansen, Raquel Munoz-Moreno, Alicia Solorzano Quijano
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Publication number: 20230218738Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.Type: ApplicationFiled: March 29, 2023Publication date: July 13, 2023Inventors: Ye Che, Philip Ralph Dormitzer, Alexey Vyacheslavovich Gribenko, Luke David Handke, Avvari Krishna Prasad, Xiayang Qiu, Mark Edward Ruppen, Xi Song, Kena Anne Swanson, Srinivas Kodali, Xin Xu, KariAnn Sweeney Efferen, Ping Cai, Kristin Rachael Tompkins, Lorna del Pilar Nunez
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Patent number: 11629172Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.Type: GrantFiled: December 19, 2019Date of Patent: April 18, 2023Assignee: Pfizer Inc.Inventors: Philip Ralph Dormitzer, Ye Che, Xiaoyuan Sherry Chi, Seungil Han, Kyle Paul Heim, Thomas Richard Jones, Yuhang Liu, Xiayang Qiu, Xinzhen Yang, Xiaojie Yao, Matthew Curtis Griffor, Jennifer Anne Nicki
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Publication number: 20220362372Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more influenza antigens, such as hemagglutinin antigens.Type: ApplicationFiled: April 29, 2022Publication date: November 17, 2022Inventors: Philip Ralph Dormitzer, Advait Vijay Badkar, Christina Van Geen Hoven, Kathrin Ute Jansen, Pirada Suphaphiphat Allen, Ramin Darvari, Mark Duda
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Publication number: 20220088184Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least two introduced amino acid mutations relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.Type: ApplicationFiled: June 17, 2021Publication date: March 24, 2022Inventors: Yuhang Liu, Ye Che, Xiaoyuan Sherry Chi, Philip Ralph Dormitzer, Jennifer Anne Nicki, Xiaojie Yao
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Publication number: 20210023200Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.Type: ApplicationFiled: October 1, 2020Publication date: January 28, 2021Applicant: Pfizer Inc.Inventors: Ye Che, Philip Ralph Dormitzer, Alexey Vyacheslavovich Gribenko, Luke David Handke, Avvari Krishna Prasad, Xiayang Qiu, Mark Edward Ruppen, Xi Song, Kena Anne Swanson, Srinivas Kodali, Xin Xu, KariAnn Sweeney Efferen, Ping Cai, Kristin Rachael Tompkins, Lorna del Pilar Nunez
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Patent number: 10821171Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.Type: GrantFiled: January 8, 2019Date of Patent: November 3, 2020Assignee: Pfizer Inc.Inventors: Ye Che, Philip Ralph Dormitzer, Alexey Vyacheslavovich Gribenko, Luke David Handke, Avvari Krishna Prasad, Xiayang Qiu, Mark Edward Ruppen, Xi Song, Kena Anne Swanson, Srinivas Kodali, Xin Xu, KariAnn Sweeney Efferen, Ping Cai, Kristin Rachael Tompkins, Lorna del Pilar Nunez
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Publication number: 20200247853Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.Type: ApplicationFiled: December 19, 2019Publication date: August 6, 2020Inventors: Philip Ralph Dormitzer, Ye Che, Xiaoyuan Sherry Chi, Seungil Han, Kyle Paul Heim, Thomas Richard Jones, Yuhang Liu, Xiayang Qiu, Xinzhen Yang, Xiaojie Yao, Matthew Curtis Griffor, Jennifer Anne Nicki
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Publication number: 20200155666Abstract: New influenza donor strains for the production of reassortant influenza A viruses are provided.Type: ApplicationFiled: October 28, 2019Publication date: May 21, 2020Applicants: Synthetic Genomics, Inc.Inventors: Peter MASON, Philip Ralph DORMITZER, Heidi TRUSHEIM, Pirada SUPHAPHIPHAT
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Patent number: 10500266Abstract: New influenza donor strains for the production of reassortant influenza A viruses are provided.Type: GrantFiled: June 13, 2017Date of Patent: December 10, 2019Assignees: Seqirus UK Limited, Synthetic Genomics, Inc.Inventors: Peter Mason, Philip Ralph Dormitzer, Heidi Trusheim, Pirada Suphaphiphat
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Publication number: 20190125861Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.Type: ApplicationFiled: January 8, 2019Publication date: May 2, 2019Inventors: Ye Che, Philip Ralph Dormitzer, Alexey Vyacheslavovich Gribenko, Luke David Handke, Avvari Krishna Prasad, Xiayang Qiu, Mark Edward Ruppen, Xi Song, Kena Anne Swanson, Srinivas Kodali, Xin Xu, KariAnn Sweeney Efferen, Ping Cai, Kristin Rachael Tompkins, Lorna del Pilar Nunez
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Patent number: 10238732Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.Type: GrantFiled: February 14, 2018Date of Patent: March 26, 2019Assignee: Pfizer Inc.Inventors: Ye Che, Philip Ralph Dormitzer, Alexey Vyacheslavovich Gribenko, Luke David Handke, Avvari Krishna Prasad, Xiayang Qiu, Mark Edward Ruppen, Xi Song, Kena Anne Swanson, Srinivas Kodali, Xin Xu, KariAnn Sweeney Efferen, Ping Cai, Kristin Rachael Tompkins, Lorna del Pilar Nunez
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Publication number: 20180177864Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.Type: ApplicationFiled: February 14, 2018Publication date: June 28, 2018Inventors: Ye Che, Philip Ralph Dormitzer, Alexey Vyacheslavovich Gribenko, Luke David Handke, Avvari Krishna Prasad, Xiayang Qiu, Mark Edward Ruppen, Xi Song, Kena Anne Swanson, Srinivas Kodali, Xin Xu, KariAnn Sweeney Efferen, Ping Cai, Kristin Rachael Tompkins, Lorna del Pilar Nunez
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Patent number: 9950058Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.Type: GrantFiled: December 20, 2016Date of Patent: April 24, 2018Assignee: Pfizer Inc.Inventors: Ye Che, Philip Ralph Dormitzer, Alexey Vyacheslavovich Gribenko, Luke David Handke, Avvari Krishna Prasad, Xiayang Qiu, Mark Edward Ruppen, Xi Song, Kena Anne Swanson, Srinivas Kodali, Xin Xu, KariAnn Sweeney Efferen, Ping Cai, Kristin Rachael Tompkins, Lorna del Pilar Nunez
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Publication number: 20170326227Abstract: New influenza donor strains for the production of reassortant influenza A viruses are provided.Type: ApplicationFiled: June 13, 2017Publication date: November 16, 2017Applicants: Seqirus UK Limited, Synthetic Genomics Vaccines, Inc.Inventors: Peter MASON, Philip Ralph DORMITZER, Heidi TRUSHEIM, Pirada SUPHAPHIPHAT
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Patent number: 9708585Abstract: New influenza donor strains for the production of reassortant influenza A viruses are provided.Type: GrantFiled: December 2, 2013Date of Patent: July 18, 2017Assignee: Seqirus UK LimitedInventors: Peter Mason, Philip Ralph Dormitzer, Heidi Trusheim, Pirada Suphaphiphat
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Publication number: 20170182151Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.Type: ApplicationFiled: December 20, 2016Publication date: June 29, 2017Inventors: Ye Che, Philip Ralph Dormitzer, Alexey Vyacheslavovich Gribenko, Luke David Handke, Avvari Krishna Prasad, Xiayang Qiu, Mark Edward Ruppen, Xi Song, Kena Anne Swanson, Srinivas Kodali, Xin Xu, KariAnn Sweeney Efferen, Ping Cai, Kristin Rachael Tompkins, Lorna del Pilar Nunez
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Publication number: 20150315548Abstract: New influenza donor strains for the production of reassortant influenza A viruses are provided.Type: ApplicationFiled: December 2, 2013Publication date: November 5, 2015Applicants: Novartis AG, Synthetic Genomics Vaccines, Inc.Inventors: Peter MASON, Philip Ralph DORMITZER, Heidi TRUSHEIM, Pirada SUPHAPHIPHAT
