Patents by Inventor Philip Stashenko

Philip Stashenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inhibiting an activity of a gene product in a bone cell encoded by a nucleotide sequence comprising SEQ ID NO: 50
    Patent number: 8158123
    Abstract: The present invention features methods of treating a bone resorption disease or a bone generating disease, methods for prognosing and/or diagnosing a bone resorption disease or a bone generating disease, methods for identifying a compound that modulates bone resorption disease development or bone generating disease development, methods for determining the efficacy of a bone resorption disease therapy or a bone generating disease therapy, and oligonucleotide microarrays containing probes for genes involved in osteoclast development.
    Type: Grant
    Filed: December 11, 2003
    Date of Patent: April 17, 2012
    Assignee: Forsyth Dental Infirmary for Children
    Inventors: Philip Stashenko, Yoshimura Okamatsu, Hajime Sasaki, Richard Battaglino, Ulrike Späte
  • CHARACTERIZATION OF AN ANTIBIOTIC IMREGNATED DELIVERY SYSTEMS AS AN INTRACANAL MEDICAMENT IN ENDODONTIC THERAPY
    Publication number: 20120028222
    Abstract: Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include modified periodontal fibers and intracanal fibers.
    Type: Application
    Filed: May 23, 2011
    Publication date: February 2, 2012
    Inventors: Mario Abdennour, Philip Stashenko, Michele Scrime, Jack Gilad, J. Max Goodson
  • Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy
    Patent number: 7946849
    Abstract: Endodontic fibers including a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments, and method of using such endodontic fibers are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to intracanal treatment sites.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: May 24, 2011
    Assignee: Forsyth Dental Infirmary for Children
    Inventors: Mario Abdennour, Philip Stashenko, Michele Scrime, Jack Gilad, Max Goodson
  • Characterization of an Antibiotic Impregnated Delivery System as an Intracanal Medicament in Endodontic Therapy
    Publication number: 20080096153
    Abstract: Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include modified periodontal fibers and intracanal fibers.
    Type: Application
    Filed: December 17, 2007
    Publication date: April 24, 2008
    Inventors: Mario Abdennour, Philip Stashenko, Michele Scrime, Jack Gilad, Max Goodson
  • Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy
    Patent number: 7331787
    Abstract: Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include modified periodontal fibers and intracanal fibers.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: February 19, 2008
    Assignee: Novalar Pharmaceuticals, Inc.
    Inventors: Mario Abdennour, Philip Stashenko, Michele Scrime, Jack Gilad, Max Goodson
  • Methods for increasing bone density
    Patent number: 7326733
    Abstract: Methods and compounds for remodeling bone and treating osteopenic conditions are described. Methods and compounds for increasing bone mineral density by decreasing serotonin levels in osteoblasts are also described.
    Type: Grant
    Filed: June 2, 2003
    Date of Patent: February 5, 2008
    Assignee: The Forsyth Institute
    Inventors: Philip Stashenko, Richard Battaglino
  • Expressed genes that define the osteoclast phenotype
    Publication number: 20050214282
    Abstract: The present invention features methods of treating a bone resorption disease or a bone generating disease, methods for prognosing and/or diagnosing a bone resorption disease or a bone generating disease, methods for identifying a compound that modulates bone resorption disease development or bone generating disease development, methods for determining the efficacy of a bone resorption disease therapy or a bone generating disease therapy, and oligonucleotide microarrays containing probes for genes involved in osteoclast development.
    Type: Application
    Filed: December 11, 2003
    Publication date: September 29, 2005
    Inventors: Philip Stashenko, Yoshimura Okamatsu, Hajime Sasaki, Richard Battaglino, Ulrike Spaete
  • Osteoclast proton pump subunit
    Publication number: 20050064448
    Abstract: Novel gene encoding a human 116-kDa osteoclast proton pump subunit and the protein encoded thereby. Methods of treatment of bone mass disorders utilizing said gene, and antibodies that bind to the protein encoded by said gene.
    Type: Application
    Filed: February 20, 2004
    Publication date: March 24, 2005
    Inventors: Philip Stashenko, Yi-Ping Li
  • Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy
    Publication number: 20040191722
    Abstract: Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include modified periodontal fibers and intracanal fibers.
    Type: Application
    Filed: March 29, 2004
    Publication date: September 30, 2004
    Inventors: Mario Abdennour, Philip Stashenko, Michele Scrime, Jack Gilad, Max Goodson
  • Osteoclast proton pump subunit
    Patent number: 6777537
    Abstract: Novel gene encoding a human 116-kDa osteoclast proton pump subunit and the protein encoded thereby. Methods of treatment of bone mass disorders utilizing said gene, and antibodies that bind to the protein encoded by said gene.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: August 17, 2004
    Assignee: Forsyth Dental Infirmary for Children
    Inventors: Philip Stashenko, Yi-Ping Li
  • Methods for increasing bone density
    Publication number: 20040127573
    Abstract: Methods and compounds for remodeling bone and treating osteopenic conditions are described. Methods and compounds for increasing bone mineral density by decreasing serotonin levels in osteoblasts are also described.
    Type: Application
    Filed: June 2, 2003
    Publication date: July 1, 2004
    Inventors: Philip Stashenko, Richard Battaglino
  • Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy and method
    Patent number: 6712610
    Abstract: Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include modified periodontal fibers and intracanal fibers.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: March 30, 2004
    Assignees: Forsyth Dental Infirmary for Children, President and Fellow of Harvard College
    Inventors: Mario Abdennour, Philip Stashenko, Michele Scrime, Jack Gilad, Max Goodson
  • Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy
    Publication number: 20020164557
    Abstract: Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include modified periodontal fibers and intracanal fibers.
    Type: Application
    Filed: September 26, 2001
    Publication date: November 7, 2002
    Applicant: Forsyth Dental Infirmary for Children
    Inventors: Mario Abdennour, Philip Stashenko, Michele Scrime, Jack Gilad, Max Goodson
  • Human osteoclast-specific and -related DNA sequences
    Patent number: 6403304
    Abstract: The present invention relates to purified osteoclast-specific or -related DNA sequences and a method for identifying such sequences. DNA constructs capable of replicating osteoclast-specific or -related DNA and DNA constructs capable of directing expression in a host cell of osteoclast-specific or -related DNA are also described.
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: June 11, 2002
    Assignee: Forsyth Dental Infirmary for Children
    Inventors: Philip Stashenko, Yi-Ping Li, Anne L. Wucherpfennig
  • Human ostoclast-specific and -related genes
    Patent number: 5656728
    Abstract: The present invention relates to purified DNA sequences encoding all or a portion of an osteoclast-specific or -related gene products and a method for identifying such sequences. The invention also relates to antibodies directed against an osteoclast-specific or -related gene product. Also claimed are DNA constructs capable of replicating DNA encoding all or a portion of an osteoclast-specific or -related gene product, and DNA constructs capable of directing expression in a host cell of an osteoclast-specific or -related gene product.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 12, 1997
    Assignee: Forsyth Dental Infirmary for Children
    Inventors: Philip Stashenko, Yi-Ping Li, Anne L. Wucherpfennig
  • Methods of identifying human osteoclast-specific and related genes
    Patent number: 5624801
    Abstract: The present invention relates to a method of identifying DNA encoding an osteoclast-specific or -related gene product. The method comprises hybridizing DNA with a stromal cell+, osteoclast+probe, or with cDNA or mRNA from an osteoclastoma, and with a stromal cell+, osteoclast-probe, or with cDNA or mRNA from stromal cells; and identifying DNA which hybridizes to the stromal cell+, osteoclast+probe, or to cDNA or mRNA from osteoclastoma, but not to the stromal cell+, osteoclast-probe, or to cDNA or mRNA from stromal cells.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 29, 1997
    Assignee: Forsyth Dental Infirmary for Children
    Inventors: Philip Stashenko, Yi-Ping Li, Anne L. Wucherpfennig
  • Human osteoclast-specific and -related genes
    Patent number: 5552281
    Abstract: The present invention relates to purified DNA sequences encoding all or a portion of an osteoclast-specific or -related gene products and a method for identifying such sequences. The invention also relates to antibodies directed against an osteoclast-specific or -related gene product. Also claimed are DNA constructs capable of replicating DNA encoding all or a portion of an osteoclast-specific or -related gene product, and DNA constructs capable of directing expression in a host cell of an osteoclast-specific or -related gene product.
    Type: Grant
    Filed: February 23, 1995
    Date of Patent: September 3, 1996
    Assignee: Forsyth Dental Infirmary for Children
    Inventors: Philip Stashenko, Yi-Ping Li, Anne L. Wucherpfennig
  • Method of determining sites of active periodontal disease
    Patent number: 5328829
    Abstract: The present invention comprises a method for the determination of periodontal disease active sites within the human oral cavity by a measurement of the level of interleukin 1 beta (IL-1b) in oral tissues and gingival crevicular fluid at a particular site.
    Type: Grant
    Filed: July 5, 1990
    Date of Patent: July 12, 1994
    Assignee: Forsyth Dental Infirmary for Children
    Inventor: Philip Stashenko