Patents by Inventor Philipp Krastel

Philipp Krastel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic depsipeptides
    Patent number: 9127044
    Abstract: The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: September 8, 2015
    Assignee: NOVARTIS AG
    Inventors: Philipp Krastel, Brigitta-Maria Liechty, Josef Gottfried Meingassner, Esther Schmitt, Erwin Paul Schreiner
  • Macrocycles and their uses
    Patent number: 8691756
    Abstract: The present application describes a method of treating a bacterial infection comprising administering to a subject in need thereof a pharmaceutically acceptable amount of a defined macrocycle compound.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: April 8, 2014
    Assignee: Novartis AG
    Inventors: Roger Aki Fujimoto, Philipp Krastel, Matthew J. LaMarche
  • Macrocycles and Their Uses
    Publication number: 20130252883
    Abstract: The present application describes a method of treating a bacterial infection comprising administering to a subject in need thereof a pharmaceutically acceptable amount of a defined macrocycle compound.
    Type: Application
    Filed: May 23, 2013
    Publication date: September 26, 2013
    Inventors: Roger Aki Fujimoto, Philipp Krastel, Matthew J. LaMarche
  • Macrocycles and their uses
    Patent number: 8476224
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: July 2, 2013
    Assignee: Novartis AG
    Inventors: Roger Aki Fujimoto, Philipp Krastel, Matthew J. Lamarche
  • Use of cyclic depsipeptides to inhibit kallikrein 7
    Patent number: 8415305
    Abstract: The present application relates to cyclic depsipeptides of Formula I: or derivatives thereof, wherein X, A1, A2, A3, A4, A5, A6 and A7 are defined herein. The cyclic depsipeptides of Formula I are inhibitors of kallikrein 7 and thus can be employed for the treatment of kallikrein-7 dependent diseases.
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: April 9, 2013
    Assignee: Novartis AG
    Inventors: Philipp Krastel, Brigitta-Maria Liechty, Esther Schmitt, Erwin Paul Schreiner
  • Organic compounds
    Patent number: 8399453
    Abstract: The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example. Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: March 19, 2013
    Assignee: Novartis AG
    Inventors: Shi Hua Ang, Philipp Krastel, Seh Yong Leong, Liying Jocelyn Tan, Wei Lin Josephine Wong, Bryan K. S. Yeung, Bin Zou
  • CYCLIC DEPSIPEPTIDES
    Publication number: 20120196790
    Abstract: The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase.
    Type: Application
    Filed: February 14, 2012
    Publication date: August 2, 2012
    Applicant: NOVARTIS AG
    Inventors: Philipp KRASTEL, Brigitta-Maria LIECHTY, Josef Gottfried MEINGASSNER, Esther SCHMITT, Erwin Paul SCHREINER
  • Cyclic depsipeptides
    Patent number: 8178650
    Abstract: The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase.
    Type: Grant
    Filed: August 18, 2008
    Date of Patent: May 15, 2012
    Assignee: Novartis AG
    Inventors: Philipp Krastel, Brigitta-Maria Liechty, Josef Gottfried Meingassner, Esther Schmitt, Erwin Paul Schreiner
  • Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof
    Publication number: 20120034650
    Abstract: The present invention relates to the provision of a polynucleotide comprising one or more functional fragments of a biosynthetic gene cluster involved in the production of a compound of formula (I) or (I?). The present invention also provides a method of preparing a compound of formula (I) or (I?) or of formula (II) to (VII), (XI) to (XIV) and (XVII) and (XVIII). Moreover, the use of such compound as a pharmaceutical composition is also provided in the present invention.
    Type: Application
    Filed: February 11, 2010
    Publication date: February 9, 2012
    Applicant: NOVARTIS AG
    Inventors: Philipp Krastel, Brigitta-Maria Liechty, Charles Moore, Esther Schmitt
  • ORGANIC COMPOUNDS
    Publication number: 20110275613
    Abstract: The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example. Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.
    Type: Application
    Filed: July 19, 2011
    Publication date: November 10, 2011
    Applicant: NOVARTIS AG
    Inventors: Shi Hua ANG, Philipp KRASTEL, Seh Yong LEONG, Liying Jocelyn TAN, Wei Lin Josephine WONG, Bryan K.S. YEUNG, Bin ZOU
  • Organic compounds
    Patent number: 8053442
    Abstract: The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example, Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: November 8, 2011
    Assignee: Novartis AG
    Inventors: Shi Hua Ang, Philipp Krastel, Seh Yong Leong, Liying Jocelyn Tan, Wei Lin Josephine Wong, Bryan KS Yeung, Bin Zou
  • USE OF CYCLIC DEPSIPEPTIDES TO INHIBIT KALLIKREIN 7
    Publication number: 20110092437
    Abstract: The present application relate to cyclic depsipeptides, or derivatives thereof, having the formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7.
    Type: Application
    Filed: August 14, 2008
    Publication date: April 21, 2011
    Inventors: Philipp Krastel, Brigitta-Maria Liechty, Esther Schmitt, Erwin Paul Schreiner
  • ORGANIC COMPOUNDS
    Publication number: 20090275560
    Abstract: The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example, Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.
    Type: Application
    Filed: April 27, 2009
    Publication date: November 5, 2009
    Applicant: NOVARTIS AG
    Inventors: Shi Hua ANG, Philipp KRASTEL, Seh Yong LEONG, Liying Jocelyn TAN, Wei Lin Josephine WONG, Bryan K.S YEUNG, Bin ZOU
  • MACROCYCLES AND THEIR USES
    Publication number: 20090186830
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
    Type: Application
    Filed: June 3, 2008
    Publication date: July 23, 2009
    Inventors: Roger Aki Fujimoto, Philipp Krastel, Matthew J. LaMarche
  • Cyclic Depsipeptides
    Publication number: 20090156472
    Abstract: The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase.
    Type: Application
    Filed: August 18, 2008
    Publication date: June 18, 2009
    Inventors: Philipp Krastel, Brigitta-Maria Liechty, Joseph Gottfried Meingassner, Esther Shmitt, Erwin Paul Schreiner