Patents by Inventor Philippe Valet

Philippe Valet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction
    Patent number: 11896649
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
    Type: Grant
    Filed: September 27, 2022
    Date of Patent: February 13, 2024
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
    Inventors: Philippe Valet, Cedric Dray, Vincent Minville, Bernard Frances, Francois Labaste, Claire Vinel
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF POST-OPERATIVE COGNITIVE DYSFUNCTION
    Publication number: 20230093887
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
    Type: Application
    Filed: September 27, 2022
    Publication date: March 30, 2023
    Inventors: Philippe VALET, Cedric DRAY, Vincent MINVILLE, Bernard FRANCES, Francois LABASTE, Claire VINEL
  • Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction
    Patent number: 11484577
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: November 1, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
    Inventors: Philippe Valet, Cedric Dray, Vincent Minville, Bernard Frances, Francois Labaste, Claire Vinel
  • USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE
    Publication number: 20220000869
    Abstract: Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because of their multifactorial origin. SHP2 is a ubiquitous tyrosine phosphatase that regulates major signalling pathways (e.g. MAPK, PI3K) in response to many growth factors. The inventors evaluate whether chronic inhibition of SHP2 could improve insulin sensitivity in animal models. Obese diabetic mice were thus treated by gavage (50 mg/kg/day). And the inventors note a significant improvement in the glucose tolerance of the treated animals compared to their control, with a decreased fasting blood glucose, without any change in weight or body composition. Accordingly, the present invention relates to use of SHP2 inhibitors for the treatment of insulin resistance.
    Type: Application
    Filed: November 22, 2019
    Publication date: January 6, 2022
    Inventors: Armelle YART, Romain PACCOUD, Mylène TAJAN, Jean-Philippe PRADERE, Philippe VALET, Cédric DRAY
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF POST-OPERATIVE COGNITIVE DYSFUNCTION
    Publication number: 20210196798
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
    Type: Application
    Filed: February 14, 2017
    Publication date: July 1, 2021
    Inventors: Philippe VALET, Cedric DRAY, Vincent MINVILLE, Bernard FRANCES, Francois LABASTE, Claire VINEL
  • METHOD AND PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF DIABETES
    Publication number: 20200171127
    Abstract: The present invention relates to an APJ receptor agonist for use in the treatment or the prevention of diabetes.
    Type: Application
    Filed: September 11, 2019
    Publication date: June 4, 2020
    Inventors: Philippe VALET, Isabelle LAURELL, Laurent CAZALS, Pierre GOURDY
  • Inhibition of Chemokine CCL7 or Receptor CCR3 of Same for the Treatment and Diagnosis of Prostate Cancer
    Publication number: 20200081009
    Abstract: The invention concerns an inhibitor of the expression of chemokine CCL7 or an inhibitor of the expression of the receptor CCR3 or an inhibitor of CCL7/CCR3 interaction for the use of same to prevent or treat the extension of prostate cancer outside the prostatic capsule in a subject. The invention also concerns a method for determining the degree of aggressiveness of a prostate cancer tumour in a subject suffering from prostate cancer, comprising a step of determining the concentration or level of expression of the receptor CCR3 in a sample of prostate tumour cells obtained from said subject.
    Type: Application
    Filed: July 15, 2019
    Publication date: March 12, 2020
    Applicants: Universite Paul Sabatier (Toulouse III), Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire de Toulouse, Institute National de la Sante et de la Recherche Medicale (INSRM)
    Inventors: Catherine Muller, Victor Laurent, Adrien Guerard, Philippe Valet, Bernard Malavaud
  • Method and pharmaceutical composition for use in the treatment of diabetes
    Patent number: 10426818
    Abstract: The present invention relates to an APJ receptor agonist for use in the treatment or the prevention of diabetes.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: October 1, 2019
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paul Sabatier Toulouse, Centre Hospitalier Universitaire de Toulouse
    Inventors: Philippe Valet, Isabelle Laurell, Laurent Cazals, Pierre Gourdy
  • Inhibition of chemokine CCL7 or receptor CCR3 of same for the treatment and diagnosis of prostate cancer
    Patent number: 10401365
    Abstract: The invention concerns an inhibitor of the expression of chemokine CCL7 or an inhibitor of the expression of the receptor CCR3 or an inhibitor of CCL7/CCR3 interaction for the use of same to prevent or treat the extension of prostate cancer outside the prostatic capsule in a subject. The invention also concerns a method for determining the degree of aggressiveness of a prostate cancer tumor in a subject suffering from prostate cancer, comprising a step of determining the concentration or level of expression of the receptor CCR3 in a sample of prostate tumor cells obtained from said subject.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: September 3, 2019
    Assignees: Universite Paul Sabatier (Toulouse III), Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire de Toulouse, Institut National de la Sante et de la Recherche Medicale
    Inventors: Catherine Muller, Victor Laurent, Adrien Guerard, Philippe Valet, Bernard Malavaud
  • METHOD AND PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF DIABETES
    Publication number: 20180104306
    Abstract: The present invention relates to an APJ receptor agonist for use in the treatment or the prevention of diabetes.
    Type: Application
    Filed: March 23, 2016
    Publication date: April 19, 2018
    Inventors: Philippe VALET, Isabelle LAURELL, Laurent CAZALS, Pierre GOURDY
  • Inhibition of Chemokine CCL7 or Receptor CCR3 of Same for the Treatment and Diagnosis of Prostate Cancer
    Publication number: 20170131282
    Abstract: The invention concerns an inhibitor of the expression of chemokine CCL7 or an inhibitor of the expression of the receptor CCR3 or an inhibitor of CCL7/CCR3 interaction for the use of same to prevent or treat the extension of prostate cancer outside the prostatic capsule in a subject. The invention also concerns a method for determining the degree of aggressiveness of a prostate cancer tumour in a subject suffering from prostate cancer, comprising a step of determining the concentration or level of expression of the receptor CCR3 in a sample of prostate tumour cells obtained from said subject.
    Type: Application
    Filed: June 16, 2015
    Publication date: May 11, 2017
    Inventors: Catherine Muller, Victor Laurent, Adrien Guerard, Philippe Valet, Bernard Malavaud
  • Pharmaceutical composition for use in the treatment of dysfunction associated with aging
    Patent number: 9381229
    Abstract: The present invention relates to an APJ receptor agonist or an apelinomimetic for use in the treatment or the prevention of a dysfunction associated with aging.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: July 5, 2016
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Philippe Valet, Cedric Dray, Claude Knauf, Oksana Kunduzova, Isabelle Castan-Laurell
  • PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF DYSFUNCTION ASSOCIATED WITH AGING
    Publication number: 20150290286
    Abstract: The present invention relates to an APJ receptor agonist or an apelinomimetic for use in the treatment or the prevention of a dysfunction associated with aging.
    Type: Application
    Filed: November 27, 2012
    Publication date: October 15, 2015
    Inventors: Philippe VALET, Cedric DRAY, Claude KNAUF, Oksana KUNDUZOVA, Isabelle CASTAN-LAURELL
  • Use of prebiotics, preferably glucooligosaccharide, for the prevention of the onset of type II diabetes
    Patent number: 7618951
    Abstract: The invention relates to the use of prebiotics for the preparation of food or pharmaceutical compositions which are intended for the treatment and/or prevention of hyperglycaemic syndromes and, in particular, for the treatment of Type II diabetes and/or the prevention of the onset of Type II diabetes in patients with a predisposition to developing the type of diabetes. The invention also relates to the food and pharmaceutical compositions containing the prebiotics.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: November 17, 2009
    Assignee: Institut National de la Recherche Agronomique
    Inventors: Pierre Monsan, Philippe Valet, Magali Remaud-Simeon, Jean-Sebastien Saulnier-Blache, Remy Burcelin
  • Use of prebiotics, preferably glucooligosaccharide, for the prevention of the onset of type II diabetes
    Publication number: 20060100172
    Abstract: The invention relates to the use of prebiotics for the preparation of food or pharmaceutical compositions which are intended for the treatment and/or prevention of hyperglycaemic syndromes and, in particular, for the treatment of Type II diabetes and/or the prevention of the onset of Type II diabetes in patients with a predisposition to developing the type of diabetes. The invention also relates to the food and pharmaceutical compositions containing the prebiotics.
    Type: Application
    Filed: September 12, 2003
    Publication date: May 11, 2006
    Applicant: Institut National De La Recherche Agronomique
    Inventors: Pierre Monsan, Philippe Valet, Magali Remaud-Simeon, Jean-Sebastien Saulnier-Blanche