Patents by Inventor Phillip D. Markham

Phillip D. Markham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrophage derived chemokine (MDC) as an anti-viral agent for the treatment and prevention of lentivirus infection
    Patent number: 6548631
    Abstract: The present invention relates to therapeutic compositions of macrophage derived chemokine (MDC) and methods for treating and preventing infection by a lentivirus, particularly an immunodeficiency virus, particularly HIV, using MDC proteins, nucleic acids and/or derivatives or analogues thereof. The present invention further relates to methods for detection and prognosis of lenivirus infection, particularly HIV infection using MDC as a prognostic indicator. The present invention further provides MDC proteins, nucleic acids encoding such proteins, that have amino-terminal sequences that differ from other MDC isolates. Recombinant host cells and methods of production are also provided.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: April 15, 2003
    Assignee: bioMérieux, Inc.
    Inventors: Anthony L. DeVico, Ranajit Pal, Robert C. Gallo, Phillip D. Markham, Alfredo Garzino-Demo
  • Molecular clones of HIV-1 viral strains MN-ST1 and BA-L, and uses thereof
    Patent number: 5869313
    Abstract: The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.
    Type: Grant
    Filed: May 14, 1996
    Date of Patent: February 9, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Marvin S. Reitz, Jr., Genoveffa Franchini, Phillip D. Markham, Robert C. Gallo, Franco C. Lori, Mikulas Popovic, Suzanne Gartner
  • Molecular clones of HIV-1 viral strains MH-ST1 and BA-L, and uses thereof
    Patent number: 5576000
    Abstract: The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST 1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.
    Type: Grant
    Filed: February 15, 1995
    Date of Patent: November 19, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Marvin S. Reitz, Jr., Genoveffa Franchini, Phillip D. Markham, Robert C. Gallo, Franco C. Lori, Mikulas Popovic, Suzanne Gartner
  • Molecular clones of HIV-1 viral strains MN-ST1 and BA-L and uses thereof
    Patent number: 5420030
    Abstract: The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.
    Type: Grant
    Filed: February 25, 1993
    Date of Patent: May 30, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Marvin S. Reitz, Jr., Genoveffa Franchini, Phillip D. Markham, Robert C. Gallo, Franco C. Lori, Mikulas Popovic, Suzanne Gartner