Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.

Abstract: In order to address the sustainability and environmental issues associated with conventional HVAC filters, inventive HVAC filters have been developed that are completely biodegradable and compostable and exhibit Minimum Efficiency Reporting Value (MERV) ratings that are superior to conventional HVAC filters. More particularly, it has been discovered that biodegradable electrospun nanofibers can be used to produce biodegradable HVAC filters that exhibit superior filtration performance relative to conventional HVAC filters produced from polypropylene electrostatic media or triboelectric nonwoven media.

Abstract: The present invention generally relates to a dual density air filtration media that comprises a plurality of nanofibers layers formed from nanofibers having different fiber diameters. Due to the presence of these multiple nanofiber layers with different nanofiber diameters, the resulting filtration media of the present invention comprises a gradient density. In particular, the present invention uses a novel combination of two or more layers of nanofibers made via an electrospinning process, wherein the nanofiber layers made up from different fiber sizes are strategically applied to a cellulose or synthetic base material or substrate, to thereby maximize the filtration efficiency and dust holding capacity of the resulting filtration media.

Abstract: The present invention generally relates to the design and manufacture of nanofiber layers, webs, films, or membranes that may be self-supporting and can function as standalone products. More particularly, the present invention relates to a microporous nanofiber films and the use of such films in a wide variety of products and applications, including applications where physical property tuning is typically limited. Generally, the microporous films of the present invention can function as a standalone nanofiber membrane or can be bonded to other microporous films to produce a layered stacked film stack with customizable properties. Unlike conventional microporous films available in today's market, the microporous films of the present invention can be lighter, require less raw material cost to produce, and can improve operating performances in a variety of applications.

Abstract: The present invention generally relates to the design and manufacture of nanofiber layers, webs, films, or membranes that may be self-supporting and can function as standalone products. More particularly, the present invention relates to a microporous nanofiber films and the use of such films in a wide variety of products and applications, including applications where physical property tuning is typically limited. Generally, the microporous films of the present invention can function as a standalone nanofiber membrane or can be bonded to other microporous films to produce a layered stacked film stack with customizable properties. Unlike conventional microporous films available in today's market, the microporous films of the present invention can be lighter, require less raw material cost to produce, and can improve operating performances in a variety of applications.

Abstract: The present invention generally relates to a dual density air filtration media that comprises a plurality of nanofibers layers formed from nanofibers having different fiber diameters. Due to the presence of these multiple nanofiber layers with different nanofiber diameters, the resulting filtration media of the present invention comprises a gradient density. In particular, the present invention uses a novel combination of two or more layers of nanofibers made via an electrospinning process, wherein the nanofiber layers made up from different fiber sizes are strategically applied to a cellulose or synthetic base material or substrate, to thereby maximize the filtration efficiency and dust holding capacity of the resulting filtration media.

Abstract: This document provides an apparatus including an awning fastener configured for attaching to an awning. The apparatus can further include a first airfoil connected to the awning fastener. The apparatus can further include a second airfoil connected to the awning fastener and positioned opposite of the first airfoil such that the first and second airfoils are positionable on opposite sides of the awning when the awning fastener is connected to the awning.

Abstract: This document provides an apparatus including an awning fastener configured for attaching to an awning. The apparatus can further include a first airfoil connected to the awning fastener. The apparatus can further include a second airfoil connected to the awning fastener and positioned opposite of the first airfoil such that the first and second airfoils are positionable on opposite sides of the awning when the awning fastener is connected to the awning.

Abstract: The prognosis of a cancer patient can be determined by analyzing the modulation of expression of specified genes in the tumor tissue. Genes uniquely up-regulated in adult stem cells that can reconstitute the tissue of the tumor are analyzed for up-regulation in the patient's tumor. Up-regulation of a plurality of such genes in the tumor is an indication of good prognosis. Genes uniquely up-regulated in fetal stem cells are analyzed for up-regulation in the patient's tumor. Up-regulation of a plurality of such genes in the tumor are an indication of a poor prognosis. Specific genes are disclosed, the modulation of which, in a patient's prostate cancer tumor, will serve as an indication of prognosis. Patients with a good prognosis are subjected to watchful waiting. Patients with a poor prognosis are aggressively treated. Kits are provided containing a set of affinity reagents that specifically detect expression of the various genes.

Abstract: The prognosis of a cancer patient can be determined by analyzing the modulation of expression of specified genes in the tumor tissue. Genes uniquely up-regulated in adult stem cells that can reconstitute the tissue of the tumor are analyzed for up-regulation in the patient's tumor. Up-regulation of a plurality of such genes in the tumor is an indication of good prognosis. Genes uniquely up-regulated in fetal stem cells are analyzed for up-regulation in the patient's tumor. Up-regulation of a plurality of such genes in the tumor are an indication of a poor prognosis. Specific genes are disclosed, the modulation of which, in a patient's prostate cancer tumor, will serve as an indication of prognosis. Patients with a good prognosis are subjected to watchful waiting. Patients with a poor prognosis are aggressively treated. Kits are provided containing a set of affinity reagents that specifically detect expression of the various genes.

Abstract: A PLM system, method, and computer readable medium. A method includes constructing an engineering design structure of a product that corresponds to physical parts of the product as designed. The method includes constructing an as-built design structure of the product that corresponds to physical parts of the product as built. The method includes displaying a bill of materials (BOM) window view that includes representations of both the engineering design structure and the as-built design structure.

Abstract: A PLM system, method, and computer readable medium. A method includes constructing an engineering design structure of a product that corresponds to physical parts of the product as designed. The method includes constructing an as-built design structure of the product that corresponds to physical parts of the product as built. The method includes displaying a bill of materials (BOM) window view that includes representations of both the engineering design structure and the as-built design structure.

Abstract: A PLM system, method, and computer readable medium. A method includes receiving a persistence model of a physical assembly and transforming the persistence model to a bill of materials (BOM) window that includes a plurality of BOM lines each corresponding to a physical part. The method includes constructing an engineering design structure corresponding to the physical assembly and creating a hybrid BOM window by combining the engineering design structure with the BOM window. The hybrid BOM window includes a plurality of hybrid BOM lines. The method includes displaying a BOM window view based on the hybrid BOM window.

Abstract: A PLM system, method, and computer readable medium. A method includes receiving a persistence model of a physical assembly and transforming the persistence model to a bill of materials (BOM) window that includes a plurality of BOM lines each corresponding to a physical part. The method includes constructing an engineering design structure corresponding to the physical assembly and creating a hybrid BOM window by combining the engineering design structure with the BOM window. The hybrid BOM window includes a plurality of hybrid BOM lines. The method includes displaying a BOM window view based on the hybrid BOM window.

Abstract: A template and method for sizing horseshoes. The template includes a plate against which ground-contacting portion of a horse's hoof is placed. The plate has a plurality of adjustment members thereon. Each adjustment member is individually movable from a first position remote from a perimeter of said hoof, to a second position adjacent the perimeter. When the adjustment members are all in the second position, they are locked into position. The adjustment members define a region that is generally shaped to conform to the perimeter of the horse's hoof. The farrier works a horseshoe until the shoe is able to be received within the region defined by the adjustment members. The worked horseshoe may then be nailed to the horse's hoof.

Abstract: A template and method for sizing horseshoes. The template includes a plate against which ground-contacting portion of a horse's hoof is placed. The plate has a plurality of adjustment members thereon. Each adjustment member is individually movable from a first position remote from a perimeter of said hoof, to a second position adjacent the perimeter. When the adjustment members are all in the second position, they are locked into position. The adjustment members define a region that is generally shaped to conform to the perimeter of the horse's hoof. The farrier works a horseshoe until the shoe is able to be received within the region defined by the adjustment members. The worked horseshoe may then be nailed to the horse's hoof.

Abstract: A computer system and method for a pay for performance advertising system which comprises an account database maintained in computer readable media, the account database comprising a plurality of advertising accounts having funds associated therewith. The computer system further comprises an advertiser database maintained in computer readable media, the advertiser database comprising an advertising unit associated with one or more participating advertisers and bid denominations associated with the participating advertisers. The computer system also comprises a query processing section operatively coupled to the advertiser database.

Abstract: A computer system for a pay for performance advertising system comprises an advertiser account database maintained in computer readable media the advertiser account database including a plurality of advertising accounts having funds associated with a plurality of transactional channels, an advertiser keyword database maintained in computer readable media, the advertiser keyword database divided into a plurality of partitions, each partition capable of having an advertiser listing associated with an advertising content page of an advertising client computer and including a keyword having a bid denomination. A query processing subsection is operatively coupled to the advertiser keywords database and is programmed to submit a search query responsive to a search term generated on a query client to the advertiser keyword database to determine a set of advertiser listings associated with a partition in the advertising keyword database in which to process the query, and to return search results to the query client.

Abstract: A method for providing advertising services in general media using a pay-for-performance model is provided. A service provider defines at least one biddable advertisement for presentation in advertising media. A bid amount chargeable to a participating advertiser upon a response to the at least one biddable advertisement is determined, generally by an open auction conducted by the service provider. The biddable advertisement is associated with a participating advertiser based, at least in part, on the bid amount. As responses to the biddable advertisement are received by the service provider, they are provided to the associated participating advertiser and that participating advertiser is charged the bid amount for the response. The advertiser associated with a biddable ad can change in real time based on the auction and association mechanisms used by the service provider, such as a bid weighted rotation which associates the biddable ad to a number of participating advertisers.