Abstract: A magnetic recording hard disk drive (HDD) uses adaptive braking of the voice coil motor (VCM) actuator upon unexpected loss of power during a track seek. An adaptive braking controller applies a preselected value of brake voltage to the VCM to reverse the motion of the freely-moving actuator. The value of the selected brake voltage is determined from the actuator velocity. A set. Of brake voltage values is stored in memory in the HDD, and each brake voltage value corresponds to a band of track seek lengths, with each band representing a range of actuator velocities. For each seek, the value of brake voltage corresponding to the band in which the seek length falls is stored in a register. If emergency power-off (EPO) occurs during the seek, the value of brake voltage is recalled from the register and applied to the VCM to brake the VCM. After the VCM has been adaptively braked in this manner, actuator retract occurs to unload the heads.

Abstract: When a HDD is operating at a temperature below a threshold, a partial sine wave is input to the spindle motor to activate the motor to reduce undesirable speed oscillations of the motor. At normal operating temperatures a full since wave is input for noise reduction.

Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Abstract: Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C1-12 alkyl, C2-12 aminoalkyl or C2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R3 and R4 are not both hydrogen; R5 is selected from the group consisting of a carbonyl, a substituted or unsubstituted C1-3 alkyl, a substituted or unsubstituted —C1-3 alkyl-C(O), a substituted or unsubstituted —C(O)—C1-3 alkyl, and a substituted or unsubstituted —C(O)C(O)C1-3 alkyl; M is a substituent capable of complexing with a protein metal ion; and L is a substituent comprising a chain of 3-12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.

Abstract: The present invention provides processes for the production of paclitaxel. Paclitaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form paclitaxel.

Abstract: A new process for resolution of an enantiomeric mixture of C3-hydroxyl substituted ?-lactams is disclosed. Generally, the enantiomeric mixture is treated with an optically active proline acylating agent to form a C3-ester substituted ?-lactam diastereomer or a mixture of C3-ester substituted ?-lactam diastereomers followed by selective recovery of the unreacted enantiomer or of one of the diastereomers.

Abstract: The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.