Patents by Inventor Pier G. Ferrini
Pier G. Ferrini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5384319Abstract: Aminoalkylphenyl derivatives of formula I ##STR1## wherein alk, R.sub.1 -R.sub.6, X and Y are as defined in the description, and salts thereof, exhibit properties inhibiting the biosynthesis of interleukin-1 (IL-1) and analgesic properties and can therefore be used as active ingredients in medicaments. They are prepared in a manner known per se.Type: GrantFiled: December 20, 1993Date of Patent: January 24, 1995Assignee: Ciba-Geigy CorporationInventor: Pier G. Ferrini
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Patent number: 5380726Abstract: Substituted dialkylthio ethers of formula I ##STR1## wherein R.sub.1 -R.sub.6, alk, X and Y are as defined in the description, and salts thereof, exhibit properties inhibiting the biosynthesis of interleukin-1 (IL-1) and analgesic properties and can therefore be used as active ingredients in medicaments. They are prepared in a manner known per se.Type: GrantFiled: December 20, 1993Date of Patent: January 10, 1995Assignee: Ciba-Geigy CorporationInventor: Pier G. Ferrini
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Patent number: 5321027Abstract: N-Benzoyl-N'-(2-phenylethyl)-piperazines of formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 have the meanings as defined in the specification, and salts thereof, have analgesic properties and can be used as analgesic active ingredients in medicaments. They are prepared, for example, as follows: a compound of formula II ##STR2## wherein X.sub.1 is carboxy or reactive functionally modified carboxy, or a salt thereof, is reacted with a compound of formula III ##STR3## wherein X.sub.2 is hydrogen.Type: GrantFiled: February 22, 1993Date of Patent: June 14, 1994Assignee: Ciba-Geigy CorporationInventors: Pier G. Ferrini, Peter Burckhardt
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Patent number: 5286728Abstract: Amino-substituted piperazine derivatives of formula I ##STR1## wherein R.sub.1 -R.sub.6, X and Y are as defined in the description, and salts thereof, have properties inhibiting the biosynthesis of interleukin-1 (IL-1) as well as analgesic properties and can therefore be used as active ingredients in medicaments. They are prepared in a manner known per se.Type: GrantFiled: July 14, 1992Date of Patent: February 15, 1994Assignee: Ciba-Geigy CorporationInventor: Pier G. Ferrini
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Patent number: 5229405Abstract: Compounds of the formula I ##STR1## in which R.sub.1 is lower alk-2-en-1-yl, lower alk-3-en-2-yl, lower alk-2-yn-1-yl or lower alkyl substituted in the 2,3-position by radicals which can be eliminated to give a double bond, R.sub.2 is hydrogen and R.sub.3 is methyl which is unsubstituted or substituted by radicals which can be eliminated together with hydrogen R.sub.2 to give a double bond or R.sub.2 and R.sub.3 are both hydrogen or lower alkyl or are together methylene and R.sub.4 is a group of the formula Ia, Ib or Ic ##STR2## in which R.sub.5 is hydrogen, lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-1-yl and R.sub.6 is a group of the formula Id or Ie ##STR3## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.5 are as defined, and their pharmaceutically acceptable salts can be used in a novel manner for the treatment of diseases of the rheumatoid type.Type: GrantFiled: April 10, 1992Date of Patent: July 20, 1993Assignee: Ciba-Geigy CorporationInventors: Ulrich Feige, Irmgard Wiesenberg, Leo Widler, Pier G. Ferrini, Martin Missbach
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Patent number: 5177091Abstract: Compounds of formula I ##STR1## wherein X and Y are each independently of the other thio or sulfynyl, R.sub.1 is lower alk-2-en-1-yl, lower alk-3-en-2-yl, lower alk-2--yn-1-yl, or lower alkyl that is substituted in the 2,3-position by radicals that can be eliminated to form a double bond, R.sub.2 is hydrogen and R.sub.3 is unsubstituted methyl or methyl substituted by a radical that can be eliminated together with hydrogen Rhd 2 to form a double bond, or R.sub.2 and R.sub.3 are each hydrogen or lower alkyl or together are methylene, R.sub.4 is free or protected hydroxy, or hydrogen, and R.sub.5 is hydrogen, lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or lower alkyl that is substituted in the 2,3-position by radicals that can be eliminated to form a double bond, and their pharmaceutically acceptable salts may be used in a novel manner for the treatment of disorders of the rheumatoid type.Type: GrantFiled: November 20, 1991Date of Patent: January 5, 1993Assignee: Ciba-Geigy CorporationInventors: Ulrich Feige, Irmgard Wiesenberg, Leo Widler, Pier G. Ferrini, Martin Missbach
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Patent number: 5147889Abstract: Benzo[b]thiophene derivatives of formula ##STR1## their tautomers and salts, in which the index n is 0, 1 or 2, alk is lower alkylene, Ar is phenyl, naphthyl or a monocyclic, five- or six-membered heteroaryl radical, wherein the aromatic radical is unsubstituted or is mono- or poly-substituted by lower alkyl, halo-lower alkyl, halogen and/or nitro, and the ring A is unsubstituted or is mono- or poly-substituted by lower alkyl, lower alkoxy, lower alkylthio, lower alkanesulfinyl, lower alkanesulfonyl, halo-lower alkyl, halogen and/or by nitro, can be used, for example, as active ingredients in medicaments.Type: GrantFiled: June 27, 1991Date of Patent: September 15, 1992Assignee: Ciba-Geigy CorporationInventor: Pier G. Ferrini
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Patent number: 5139786Abstract: The invention relates to topically administrable pharmaceutical preparations containing pharmaceutically acceptable methanediphosphonic acid derivatives of formula ##STR1## and their salts, wherein R.sub.1 and R.sub.2 are hydrogen or C.sub.1 -C.sub.3 alkyl.Type: GrantFiled: December 20, 1991Date of Patent: August 18, 1992Assignees: Ciba-Geigy Corporation, Henkel Kommanditgesellschaft auf AktienInventors: Pier G. Ferrini, Carlo Voellmy, Peter H. Stahl, Jonathan Green
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Patent number: 5133972Abstract: The invention relates to topically adminstrable pharmaceutical preparations containing pharmaceutically acceptable methanediphosphonic acid derivatives of formula ##STR1## and their salts, wherein each of R.sub.1 and R.sub.2 is halogen, or wherein R.sub.1 is hydrogen and R.sub.2 is Ar--S-- or Het.sub.1 --NH--, in which Ar is unsubstituted or substituted phenyl and Het.sub.1 is unsubstituted or substituted, monocyclic, 5- or 6-membered monoaza-, diaza- or thiaza-aryl that is bonded via a ring carbon atom, or wherein R.sub.1 is hydrogen or hydroxy and R.sub.2 is --A--R.sub.3, in which A is alkylene and, on the one hand, R.sub.3 is Het.sub.2, which is Het.sub.1 bonded via a ring carbon or ring nitrogen atom, or, on the other hand, R.sub.3 is hydrogen, or amino that is unsubsituted or mono- or di-substituted by identical or different substituents selected from alkyl, cycloalkyl, Ar-alkyl, Ar-O-alkyl, Ar-S-alkyl and Het.sub.Type: GrantFiled: June 29, 1990Date of Patent: July 28, 1992Assignee: Ciba-Geigy CorporationInventors: Pier G. Ferrini, Carlo Voellmy, Peter H. Stahl, Jonathan Green
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Patent number: 5051421Abstract: Benzo[b]thiophene derivatives of formula ##STR1## their tautomers and salts, in which the index n is 0, 1 or 2, alk is lower alkylene, Ar is phenyl, naphthyl or a monocyclic, five- or six-membered heteroaryl radical, wherein the aromatic radical is unsubstituted or is mono- or poly-substituted by lower alkyl, halo-lower alkyl, halogen and/or by nitro, and the ring A is unsubstituted or is mono- or poly-substituted by lower alkyl, lower alkoxy, lower alkylthio, lower alkanesulfinyl, lower alkanesulfonyl, halo-lower alkyl, halogen and/or by nitro, can be used, for example, as active ingredients in medicaments.Type: GrantFiled: January 18, 1990Date of Patent: September 24, 1991Assignee: Ciba-Geigy CorporationInventor: Pier G. Ferrini
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Patent number: 4804661Abstract: Piperazines of the formula ##STR1## and their salts, in which each of Ar.sub.1 and Ar.sub.2, independently of the other, represents phenyl that is unsubstituted or mono- or di-substituted by C.sub.1 -C.sub.7 -alkyl, C.sub.1 -C.sub.7 -alkoxy, cyano, halogen, trifluoromethyl, amino, C.sub.1 -C.sub.7 -alkylamino, di-C.sub.1 -C.sub.7 -alkylamino and/or by C.sub.1 -C.sub.7 -alkanoylamino, can be used as the active ingredients of medicaments and are manufactured in a manner known per se.Type: GrantFiled: June 9, 1987Date of Patent: February 14, 1989Assignee: Ciba-Geigy CorporationInventors: Pier G. Ferrini, Andreas v. Sprecher
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Patent number: 4608382Abstract: Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R.sub.1 and R.sub.2 is a substituted or unsubstituted heteroaryl group and the other is a substituted or unsubstituted aryl group, R.sub.3 is hydrogen or lower alkyl, n is 0, 1 or 2 and R.sub.4 is a substituted or unsubstituted aliphatic hydrocarbon radical and their pharmaceutically usable salts exhibit anti-inflammatory, anti-nociceptive and/or antithrombotic activity.Type: GrantFiled: March 9, 1984Date of Patent: August 26, 1986Assignee: Ciba-Geigy CorporationInventors: Pier G. Ferrini, Richard Goschke
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Patent number: 4584310Abstract: Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R.sub.1 and R.sub.2 is a substituted or unsubstituted heteroaryl group and the other is a substituted or unsubstituted aryl group, R.sub.3 is hydrogen or lower alkyl, n is 0, 1 or 2 and R.sub.4 is a substituted or unsubstituted aliphatic hydrocarbon radical and their pharmaceutically usable salts exhibit anti-inflammatory, anti-nociceptive and/or antithrombotic activity.Type: GrantFiled: March 9, 1984Date of Patent: April 22, 1986Assignee: Ciba-Geigy CorporationInventors: Pier G. Ferrini, Richard Goschke
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Patent number: 4523030Abstract: Substituted benzophenones of the formula ##STR1## in which Ph represents unsubstituted or substituted phenyl and R represents free, esterified or amidated carboxy, have anti-inflammatory and/or analgesic properties and can be used as active ingredients in medicaments. They are manufactured, for example, as follows:a compound or a mixture of compounds of the formula ##STR2## in which X.sub.1 and X.sub.2 together represent a group of the formula --C(.dbd.O)--O that is bonded via the carbonyl group to the radical Ph and X.sub.3 represents hydrogen, or one of the radicals X.sub.1 and X.sub.3 represents a group of the formula --C(.dbd.O)--Z, the other represents hydrogen and X.sub.2 represents a group R'O-- in which R' represents hydrogen or a hydroxy-protecting group, is subjected to acid treatment and the primary product is decomposed solvolytically.Type: GrantFiled: June 7, 1984Date of Patent: June 11, 1985Assignee: Ciba-Geigy CorporationInventors: Georges Haas, Andreas von Sprecher, Pier G. Ferrini
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Patent number: 4505913Abstract: Substituted anthranilamides of the formula ##STR1## in which R.sub.1 is hydrogen or an aliphatic, cycloaliphatic or cycloaliphatic-aliphatic hydrocarbon radical, R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, R.sub.3 is hydrogen or an aliphatic or substituted or unsubstituted araliphatic or heteroaryl-aliphatic hydrocarbon radical and alk and alk' are identical or different lower alkylene radicals which separate the nitrogen atoms by 2 or 3 carbon atoms, and salts thereof, possess analgesic, anti-inflammatory and anti-allergic properties and may be used as active ingredients of analgesic, anti-inflammatory and anti-allergic pharmaceuticals. They are prepared, for example, by reacting an acid of the formula ##STR2## or a reactive functional derivative thereof, with an amine of the formula ##STR3## or a reactive derivative or salt thereof.Type: GrantFiled: September 30, 1982Date of Patent: March 19, 1985Assignee: Ciba-Geigy CorporationInventors: Pier G. Ferrini, Alberto Rossi, Georges Haas
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Patent number: 4476132Abstract: Quinolinone derivatives of the formula (I) ##STR1## in which X represents oxy or a direct bond, R.sub.1 represents an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical or hydrogen, Ph represents an optionally additionally substituted 1,2-phenylene radical containing the group R.sub.1 --X--C(O)--, and one of the radicals R.sub.2 and R.sub.3 represents an optionally esterified or amidated carboxy group R.sub.4 and the other represents hydrogen or an aliphatic radical or, in the case of a radical R.sub.3, hydroxy, and in which either R.sub.A and R.sub.B together represent oxo, R.sub.C and R.sub.D together represent an additional bond, or, when R.sub.2 represents a radical R.sub.4, R.sub.C is hydrogen and R.sub.3 and R.sub.D together represent oxo, and R.sub.E represents a radical R.sub.5 which represents hydrogen or an aliphatic, cycloaliphatic, araliphatic heterocyclic-aliphatic radical, or R.sub.A represents an optionally etherified hydroxy group and R.sub.Type: GrantFiled: March 19, 1982Date of Patent: October 9, 1984Assignee: Ciba-Geigy CorporationInventors: Richard Goschke, Pier G. Ferrini, Alfred Sallmann
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Patent number: 4461770Abstract: Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R.sub.1 and R.sub.2 is a substituted or unsubstituted heteroaryl group and the other is a substituted or unsubstituted aryl group, R.sub.3 is hydrogen or lower alkyl, n is 0, 1 or 2 and R.sub.4 is a substituted or unsubstituted aliphatic hydrocarbon radical and their pharmaceutically usable salts exhibit anti-inflammatory, anti-nociceptive and/or antithrombotic activity.Type: GrantFiled: November 16, 1981Date of Patent: July 24, 1984Assignee: Ciba-Geigy CorporationInventors: Pier G. Ferrini, Richard Goschke
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Patent number: 4451471Abstract: 2,4,5-Trisubstituted thiazoles of the formula ##STR1## in which each of R.sub.1 and R.sub.2, independently of the other, represents an aryl or optionally N-oxidized heteroaryl radical each of which is unsubstituted or substituted by aliphatic hydrocarbon radicals, free, etherified or esterified hydroxy, etherified optionally S-oxidized mercapto, aliphatically substituted amino and/or trifluoromethyl,X represents thio,n represents 0, 1, or 2, andR.sub.3 represents an aliphatic hydrocarbon radical that is unsubstituted or substituted by etherified or esterified hydroxy, etherified optionally S-oxidized mercapto and/or, in a position higher than the .alpha.-position, by oxo and/or hydroxy and optionally contains, in addition to terminally bonded hydroxy, sulpho that is present in salt form, or represents an araliphatic hydrocarbon radical that is unsubstituted or substituted in the aryl moiety as indicated for R.sub.1 and R.sub.Type: GrantFiled: March 8, 1982Date of Patent: May 29, 1984Assignee: Ciba-Geigy CorporationInventors: Pier G. Ferrini, Richard Goschke
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Patent number: 4396621Abstract: Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]-thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.Type: GrantFiled: November 7, 1980Date of Patent: August 2, 1983Assignee: Ciba-Geigy CorporationInventors: Raymond Bernasconi, Pier G. Ferrini, Richard Goschke, Jacques Gosteli
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Patent number: 4353918Abstract: The invention relates to the dextrorotatory enantiomer of trans-5,6-di-p-methoxyphenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole and its pharmaceutically acceptable salts and to pharmaceutical preparations containing them.The new compounds have valuable pharmacological properties, especially anti-inflammatory and anti-rheumatic effects.Type: GrantFiled: December 22, 1980Date of Patent: October 12, 1982Assignee: Ciba-Geigy CorporationInventors: Richard Goschke, Pier G. Ferrini